Abstract：
:The orderly reduction in chromosome number that occurs during meiosis depends on two aspects of chromosome behavior specific to the first meiotic division. These are the retention of cohesion between sister centromeres and their attachment to microtubules that extend to the same pole (monopolar attachment). By deleting genes that are upregulated during meiosis, we identified in Saccharomyces cerevisiae a kinetochore associated protein, Mam1 (Monopolin), which is essential for monopolar attachment. We also show that the meiosis-specific cohesin, Rec8, is essential for maintaining cohesion between sister centromeres but not for monopolar attachment. We conclude that monopolar attachment during meiosis I requires at least one meiosis-specific protein and is independent of the process that protects sister centromere cohesion.
journal_name
Celljournal_title
Cellauthors
Tóth A,Rabitsch KP,Gálová M,Schleiffer A,Buonomo SB,Nasmyth Kdoi
10.1016/s0092-8674(00)00217-8subject
Has Abstractpub_date
2000-12-22 00:00:00pages
1155-68issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(00)00217-8journal_volume
103pub_type
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