Reviving the exosome.

Abstract:

:In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et al. (2005) help to solve this riddle by characterizing a new RNA decay-activating complex containing a poly(A) polymerase. In addition, they identify new unconventional RNA polymerase II transcription units.

journal_name

Cell

journal_title

Cell

authors

Jensen TH,Moore C

doi

10.1016/j.cell.2005.05.018

subject

Has Abstract

pub_date

2005-06-03 00:00:00

pages

660-2

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(05)00497-6

journal_volume

121

pub_type

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