Abstract:
:In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et al. (2005) help to solve this riddle by characterizing a new RNA decay-activating complex containing a poly(A) polymerase. In addition, they identify new unconventional RNA polymerase II transcription units.
journal_name
Celljournal_title
Cellauthors
Jensen TH,Moore Cdoi
10.1016/j.cell.2005.05.018subject
Has Abstractpub_date
2005-06-03 00:00:00pages
660-2issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00497-6journal_volume
121pub_type
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