Abstract：
:When human lymphoblastoid mRNA was microinjected into X. laevis oocytes, titers of interferon rapidly reached a maximum inside the oocyte while accumulation of interferon continued in the incubation medium for at least 45 hr. If interferon protein was injected into oocytes it was rapidly inactivated. Significantly, newly synthesized interferon but not injected interferon was found to be membrane-associated. Further experiments involving the co-injection of mRNAs coding for secretory proteins (guinea pig milk proteins and human interferon) and nonsecretory proteins (rabbit globin) revealed that only the secretory proteins were exported from the oocyte. Moreover, different proteins were exported at different rates. A distinct subclass of newly synthesized oocyte proteins of unknown function also accumulated in the incubation medium. Since the information encoded in the messenger RNAs of secretory proteins is sufficient to specify synthesis, compartmentation and secretion of these proteins, the oocyte may provide a complete system for the analysis of the secretory process.
journal_name
Celljournal_title
Cellauthors
Colman A,Morser Jdoi
10.1016/0092-8674(79)90260-5subject
Has Abstractpub_date
1979-07-01 00:00:00pages
517-26issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(79)90260-5journal_volume
17pub_type
杂志文章相关文献
CELL文献大全abstract：:The Xist gene maps to the X inactivation center region in both mouse and human, and previous analysis of the 3' end of the gene has demonstrated inactive X-specific expression, suggesting a possible role in X inactivation. We have now analyzed the entire mouse Xist gene. The mature inactive X-specific transcript is 15...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90519-i
更新日期：1992-10-30 00:00:00
abstract：:The interplay of genetics and the environment in the etiology of Alzheimer's disease (AD) is not well understood. Now, Lazarov and coworkers show that a simple paradigm of environmental enrichment alleviates amyloid burden and alters disease-associated gene expression changes in a double transgenic mouse model of AD. ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2005.02.027
更新日期：2005-03-11 00:00:00
abstract：:Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component of a pathway that co...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.12.036
更新日期：2005-03-11 00:00:00
abstract：:Hematopoietic stem cells (HSCs) exist in the bone marrow and circulate in the blood. In this issue, Massberg et al. (2007) report that HSCs also travel through the lymphatic system. Furthermore, migration of HSCs--which express Toll-like receptors--allows the recognition of pathogenic molecules in peripheral tissues t...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2007.11.010
更新日期：2007-11-30 00:00:00
abstract：:A gel electrophoresis DNA binding assay has been used to identify proteins in HeLa cell extracts that specifically bind to the major late promoter of adenovirus. A major late promoter transcription factor MLTF has been detected as a discrete protein-DNA complex. MLTF binds specifically and with high affinity to sequen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90174-6
更新日期：1985-12-01 00:00:00
abstract：:Specific active transcription units on chromosome IV in the salivary glands of Chironomus tentans have been visualized by the Miller spreading technique and in situ by conventional electron microscopy. These units are likely to be located in the two most conspicuous puffs on chromosome IV, Balbiani ring 1 (BR 1) and B...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90324-6
更新日期：1979-08-01 00:00:00
abstract：:A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and may mediate the effects of calorie restriction. In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast a...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2005.01.029
更新日期：2005-02-25 00:00:00
abstract：:STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.09.022
更新日期：2011-10-14 00:00:00
abstract：:Two-component signal transduction systems are the predominant means by which bacteria sense and respond to environmental stimuli. Bacteria often employ tens or hundreds of these paralogous signaling systems, comprised of histidine kinases (HKs) and their cognate response regulators (RRs). Faithful transmission of info...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.04.040
更新日期：2008-06-13 00:00:00
abstract：:The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular matter have led to debate about contents and functional properties of exosomes. Here, we employ high-resolution density gradient fractionation and direct immunoaffinity capture to precisely characterize the RNA, DNA, and prot...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.02.029
更新日期：2019-04-04 00:00:00
abstract：:Two allelic forms of the natural chicken ovalbumin gene have been independently cloned. These alleles differ from each other by an Eco RI restriction cleavage site in one of the seven intervening sequences within the natural ovalbumin gene. Restriction endonuclease mapping and sequence analyses of these cloned genotyp...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90201-0
更新日期：1979-01-01 00:00:00
abstract：:Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.04.052
更新日期：2016-05-05 00:00:00
abstract：:Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increase in intracellular ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.03.029
更新日期：2015-04-23 00:00:00
abstract：:Multidrug resistance in human cells results from increased expression of the mdr1 (P-glycoprotein) gene. Although the same gene is activated in cells selected with different drugs, multidrug-resistant cell lines can be preferentially resistant to their selecting agent. The mdr1 cDNA sequence from vinblastine-selected ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90568-5
更新日期：1988-05-20 00:00:00
abstract：:Multipotent cardiac progenitor cells are found in the fetal and adult heart of many mammalian species including humans and form as intermediates during the differentiation of embryonic stem cells. Despite similar biological properties, the molecular identities of these different cardiac progenitor cell populations app...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.02.002
更新日期：2008-02-22 00:00:00
abstract：:Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.12.018
更新日期：2005-02-11 00:00:00
abstract：:Xenopus laevis oocytes were used as a model system to study the intracellular fate of proteins incorporated by endocytosis. We found that the intracellular stability and compartmentation of proteins incorporated by receptor-mediated endocytosis differed substantially from that of proteins incorporated by nonspecific e...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90153-1
更新日期：1980-11-01 00:00:00
abstract：:Pejvakin (PJVK), a protein originally identified in Persian families with sensorineural hearing loss, regulates peroxisomal dynamics and the antioxidant defense triggered by noise exposure in hair cells and auditory neurons of the inner ear. These findings bring peroxisomes to the forefront of noise-induced hearing lo...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.10.060
更新日期：2015-11-05 00:00:00
abstract：:Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circa...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.04.020
更新日期：2013-05-09 00:00:00
abstract：:Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at...
journal_title：Cell
pub_type： 杂志文章,收录出版
doi：10.1016/s0092-8674(02)01037-1
更新日期：2002-10-18 00:00:00
abstract：:Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin. Vitellogenin synthesis, as a primary response, is first detectable on the fourth day of culture, and comprises up to 12% of the protein synthesiz...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90263-4
更新日期：1976-01-01 00:00:00
abstract：:The assembly of new histones into nucleosomes and the segregation of old histones during replication were investigated using a density gradient, sedimentation equilibrium analysis of histones labeled in vivo with dense amino acids. After a 1 hr pulse of dense amino acids and 3H-lysine, nucleosomes were isolated from c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90282-3
更新日期：1977-11-01 00:00:00
abstract：:The structure and organization on the Escherichia coli chromosome of the gene cluster coding for two methionine tRNAs (tRNAmMet), four glutamine tRNAs (two tRNA1Gln and two tRNA2Gln), and a previously unidentified tRNA (called tRNAx) have been studied by restriction enzyme analysis and DNA sequencing, utilizing a spec...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90288-9
更新日期：1981-01-01 00:00:00
abstract：:Using X-ray crystallography, we have directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution. About 30 nucleotides of the mRNA are wrapped in a groove that encircles the neck of the 30S subunit. The Shine-Dalgarno helix is bound in a large cleft between the head and the back...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00435-4
更新日期：2001-07-27 00:00:00
abstract：:Cytotoxic T lymphocytes and lymphocytes with NK-like activity contain a serine esterase activity which has been localized to their cytoplasmic granules by cytochemistry and subcellular fractionation studies. The serine esterase-specific inhibitor 3H-DFP labels two protein species in the granules. The two proteins, ref...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90441-1
更新日期：1986-10-24 00:00:00
abstract：:Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, we examined the evolution of genes involved in diverse aspects of nervous system biology. We found that these genes display significantly higher rates of protein evolution in primates than in rodents. Impo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.11.040
更新日期：2004-12-29 00:00:00
abstract：:The sphingomyelin pathway, which is initiated by sphingomyelin hydrolysis to generate the second messenger ceramide, signals apoptosis for tumor necrosis factor alpha, Fas, and ionizing radiation. In the present studies, the anticancer drug daunorubicin also stimulated ceramide elevation and apoptosis in P388 and U937...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90429-8
更新日期：1995-08-11 00:00:00
abstract：:Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enterica serovar Typhi. Mathur et al. now report that mice lacking Toll-like receptor 11, which is absent in humans, can be lethally infected with S. Typhi, a breakthrough that promises to speed the development of better vaccines. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.10.016
更新日期：2012-10-26 00:00:00
abstract：:The dynamic synapse is represented by the constant mobility and exchange of components at both the cell surface and at intracellular sites. This includes thermally powered Brownian diffusion movement, followed by reversible trapping through receptor-scaffold interactions and active transport of cargo vesicles through ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.06.002
更新日期：2014-06-19 00:00:00
abstract：:We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00863-2
更新日期：2002-08-23 00:00:00
