SnapShot: receptor dynamics at plastic synapses.


:The dynamic synapse is represented by the constant mobility and exchange of components at both the cell surface and at intracellular sites. This includes thermally powered Brownian diffusion movement, followed by reversible trapping through receptor-scaffold interactions and active transport of cargo vesicles through cytoskeletal motors.






Kneussel M,Triller A,Choquet D




Has Abstract


2014-06-19 00:00:00
















  • The somatic replication of DNA methylation.

    abstract::We have tested the hypothesis that DNA methylation patterns are replicated in the somatic cells of vertebrates. Using M-Hpa II, the modification enzyme from Haemophilus parainfluenzae which methylates the internal cytosine residues in the sequence 5'CCGG 3' GGCC, we methylated bacteriophage phi X174 RF DNA and the clo...


    pub_type: 杂志文章


    authors: Wigler M,Levy D,Perucho M

    更新日期:1981-04-01 00:00:00

  • Identification and purification of a protein that binds the yeast ARS consensus sequence.

    abstract::We have identified a yeast protein that binds specifically to the ARS consensus sequence. By two-step chromatography we have purified the factor to apparent homogeneity as a single polypeptide of 67 kd. The purified ARS consensus-binding protein (ACBP) recognizes the ARS consensus of the four genomic ARS elements test...


    pub_type: 杂志文章


    authors: Hofmann JF,Gasser SM

    更新日期:1991-03-08 00:00:00

  • Travel Less. Make It Worthwhile.

    abstract::Academic travel has a substantial carbon footprint. The ongoing pandemic has propelled the development and adoption of technologies for online delivery of seminars and remote attendance at scientific conferences. This should not lead to the complete elimination of in-person events, but the scientific community must se...


    pub_type: 杂志文章


    authors: Geitmann A

    更新日期:2020-08-20 00:00:00

  • HIV-1 at 25.

    abstract::In 1981, the acquired immunodeficiency syndrome (AIDS) appeared insidiously and mystified doctors and scientists alike. No one could have predicted then that it would become, arguably, the worst plague in human history. Today, 33 million persons are living with infection by the human immunodeficiency virus type 1 (HIV...


    pub_type: 杂志文章


    authors: Ho DD,Bieniasz PD

    更新日期:2008-05-16 00:00:00

  • Sequence from early region of polyoma virus DNA containing viral replication origin and encoding small, middle and (part of) large T antigens.

    abstract::The sequence of about one third of the polyoma virus genome is presented. This sequence covers the origin of replication of two large plaque strains (A2 and A3) of polyoma virus. The two strains differ by 11 bp in the origin region. A model for replication is suggested. The sequence probably also covers the entire cod...


    pub_type: 杂志文章


    authors: Soeda E,Arrand JR,Smolar N,Griffin BE

    更新日期:1979-06-01 00:00:00

  • High frequency variation in mammary tumor virus expression in cell culture.

    abstract::Clonal derivatives of C3HMT murine mammary cell lines in culture demonstrate conversion of mammary tumor virus (MMTV) expression at a rate of appriximately 6 per 100 clones. This alteration is largely unidirectional from a relatively high level (MMTV(H)) to a 10 fold lower level (MMTV(L)). This high rate of MMTV(L) va...


    pub_type: 杂志文章


    authors: Parks WP,Hubbell ES,Goldberg RJ,O'Neill FJ,Scolnick EM

    更新日期:1976-05-01 00:00:00

  • A secondary attachment site for bacteriophage lambda in trpC of E. coli.

    abstract::We have determined the nucleotide sequence of a secondary lambda attachment site in trpC. Direct sequence analysis of lambdatrp transducing phage DNA fragments carrying the two prophage attachment sites reveals a 6 nucleotide homology in the crossover region which is a subset of the 15 nucleotide core sequence in the ...


    pub_type: 杂志文章


    authors: Christie GE,Platt T

    更新日期:1979-02-01 00:00:00

  • Direct repeats flank three small nuclear RNA pseudogenes in the human genome.

    abstract::We previously demonstrated that pseudogenes complementary to the small nuclear RNAs U1, U2 and U3 are dispersed and abundant in the human genome. Here we report that three pseudogenes (U1.101, U2.13 and U3.5) are flanked by perfect short direct repeats of 16 to 19 base pairs. In all three pseudogenes. the upstream dir...


    pub_type: 杂志文章


    authors: Van Arsdell SW,Denison RA,Bernstein LB,Weiner AM,Manser T,Gesteland RF

    更新日期:1981-10-01 00:00:00

  • Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses.

    abstract::T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the capability of CAR T cells, here, we present a split, universal, and programmable (SUPRA) CAR system that simultaneously encompasses multiple ...


    pub_type: 杂志文章


    authors: Cho JH,Collins JJ,Wong WW

    更新日期:2018-05-31 00:00:00

  • Unequal exchanges and the coevolution of X and Y rDNA arrays in Drosophila melanogaster.

    abstract::We have examined the molecular basis of the response of individuals of D. melanogaster to artificial selection for high and low abdominal bristles. By monitoring the fate of particular rDNA spacer length variants associated with individually isolated X and Y chromosomes, we show that flies from the low bristle number ...


    pub_type: 杂志文章


    authors: Coen ES,Dover GA

    更新日期:1983-07-01 00:00:00

  • Disconnected: a locus required for neuronal pathway formation in the visual system of Drosophila.

    abstract::Mutations at the X-linked disconnected locus of D. melanogaster lead to the failure of adult photoreceptor axons to innervate their target cells in the developing optic lobes of the third instar larva, resulting in flies that have rudimentary optic ganglia. The cascade of epigenetic events leading to the adult disconn...


    pub_type: 杂志文章


    authors: Steller H,Fischbach KF,Rubin GM

    更新日期:1987-09-25 00:00:00

  • Repressive Gene Regulation Synchronizes Development with Cellular Metabolism.

    abstract::Metabolic conditions affect the developmental tempo of animals. Developmental gene regulatory networks (GRNs) must therefore synchronize their dynamics with a variable timescale. We find that layered repression of genes couples GRN output with variable metabolism. When repressors of transcription or mRNA and protein s...


    pub_type: 杂志文章


    authors: Cassidy JJ,Bernasek SM,Bakker R,Giri R,Peláez N,Eder B,Bobrowska A,Bagheri N,Nunes Amaral LA,Carthew RW

    更新日期:2019-08-08 00:00:00

  • Paused RNA polymerase II as a developmental checkpoint.

    abstract::The textbook view of gene activation is that the rate-limiting step is the interaction of RNA polymerase II (Pol II) with the gene's promoter. However, studies in a variety of systems, including human embryonic stem cells and the early Drosophila embryo, have begun to challenge this view. There is increasing evidence ...


    pub_type: 杂志文章,评审


    authors: Levine M

    更新日期:2011-05-13 00:00:00

  • Structure of DNA within three isometric bacteriophages.

    abstract::This paper describes a model for the structure of DNA contained in three morphologically similar bacteriophages--T7, P22 and phiCd-1--based on the transient electric dichroism of intact phage. The reduced dichroism of each of the phages at perfect orientation is within the range +0.12 to +0.19. Assuming that the phage...


    pub_type: 杂志文章


    authors: Kosturko LD,Hogan M,Dattagupta N

    更新日期:1979-03-01 00:00:00

  • Trans-activation by HIV-1 Tat via a heterologous RNA binding protein.

    abstract::The HIV-1 trans-activator Tat increases levels of viral gene expression and replication. The target for Tat is an RNA stem-loop called TAR, located at the 5' end of all viral transcripts. To study the mechanism of action and map functional domains of Tat, we fused Tat to the coat protein of bacteriophage MS2, an RNA b...


    pub_type: 杂志文章


    authors: Selby MJ,Peterlin BM

    更新日期:1990-08-24 00:00:00

  • Phosphorylation of intermediate filament proteins by cAMP-dependent protein kinases.

    abstract::The intermediate filament proteins, desmin and vimentin, are phosphorylated in skeletal muscle cells in vivo. Desmin kinase activities have been purified from mature chicken skeletal muscle and identified as the cAMP-dependent kinases. Chicken skeletal muscle contains two cAMP-dependent protein kinases which are simil...


    pub_type: 杂志文章


    authors: O'Connor CM,Gard DL,Lazarides E

    更新日期:1981-01-01 00:00:00

  • A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.

    abstract::Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21...


    pub_type: 杂志文章


    authors: Huarte M,Guttman M,Feldser D,Garber M,Koziol MJ,Kenzelmann-Broz D,Khalil AM,Zuk O,Amit I,Rabani M,Attardi LD,Regev A,Lander ES,Jacks T,Rinn JL

    更新日期:2010-08-06 00:00:00

  • A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function.

    abstract::Septate and tight junctions are thought to seal neighboring cells together and to function as barriers between epithelial cells. We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. NRX is a transmembrane protein wi...


    pub_type: 杂志文章


    authors: Baumgartner S,Littleton JT,Broadie K,Bhat MA,Harbecke R,Lengyel JA,Chiquet-Ehrismann R,Prokop A,Bellen HJ

    更新日期:1996-12-13 00:00:00

  • A Drosophila model for xeroderma pigmentosum and Cockayne's syndrome: haywire encodes the fly homolog of ERCC3, a human excision repair gene.

    abstract::The haywire gene of Drosophila encodes a protein with 66% identity to the product of the human ERCC3 gene, associated with xeroderma pigmentosum B (XP-B) and Cockayne's syndrome (CS). XP is a human autosomal recessive disease characterized by extreme sensitivity to ultraviolet irradiation and marked susceptibility to ...


    pub_type: 杂志文章


    authors: Mounkes LC,Jones RS,Liang BC,Gelbart W,Fuller MT

    更新日期:1992-12-11 00:00:00

  • Three-dimensional visualization of the rotavirus hemagglutinin structure.

    abstract::Three-dimensional structures of a native simian and reassortant rotavirus have been determined by electron cryomicroscopy and computer image processing. The structural features of the native virus confirm that the hemagglutinin spike is a dimer of VP4, substantiated by in vivo radiolabeling studies. Exchange of native...


    pub_type: 杂志文章


    authors: Shaw AL,Rothnagel R,Chen D,Ramig RF,Chiu W,Prasad BV

    更新日期:1993-08-27 00:00:00

  • Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.

    abstract::The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. We have solved the X-ray crystal structure to 1.9 A resolution of an autoinhibited, unphosphorylated form of EphB2 comprised of the juxtamembrane region and the kinase domain. ...


    pub_type: 杂志文章


    authors: Wybenga-Groot LE,Baskin B,Ong SH,Tong J,Pawson T,Sicheri F

    更新日期:2001-09-21 00:00:00

  • Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19.

    abstract::The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4+ T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, we found...


    pub_type: 杂志文章


    authors: Meckiff BJ,Ramírez-Suástegui C,Fajardo V,Chee SJ,Kusnadi A,Simon H,Eschweiler S,Grifoni A,Pelosi E,Weiskopf D,Sette A,Ay F,Seumois G,Ottensmeier CH,Vijayanand P

    更新日期:2020-11-25 00:00:00

  • Proliferation at the heart of preadolescence.

    abstract::Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for ...


    pub_type: 评论,杂志文章


    authors: Palpant NJ,Murry CE

    更新日期:2014-05-08 00:00:00

  • Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus.

    abstract::To relate different forms of synaptic plasticity to the formation and maintenance of place cells in the hippocampus, we have recorded place cells in freely behaving, transgenic mice that express a mutated Ca2+-independent form of CaM Kinase II. These mice have normal long-term potentiation (LTP) at 100 Hz, but they la...


    pub_type: 杂志文章


    authors: Rotenberg A,Mayford M,Hawkins RD,Kandel ER,Muller RU

    更新日期:1996-12-27 00:00:00

  • Trans splicing of nematode pre-messenger RNA in vitro.

    abstract::In nematodes, a fraction of mRNAs contains a common 22 nucleotide 5' terminal spliced leader (SL) sequence derived by trans splicing. Here, we show that a cell-free extract prepared from developing embryos of the parasitic nematode Ascaris lumbricoides catalyzes accurate and efficient SL addition to a synthetic pre-mR...


    pub_type: 杂志文章


    authors: Hannon GJ,Maroney PA,Denker JA,Nilsen TW

    更新日期:1990-06-29 00:00:00

  • A cellular gene encodes scrapie PrP 27-30 protein.

    abstract::A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in...


    pub_type: 杂志文章


    authors: Oesch B,Westaway D,Wälchli M,McKinley MP,Kent SB,Aebersold R,Barry RA,Tempst P,Teplow DB,Hood LE

    更新日期:1985-04-01 00:00:00

  • Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation.

    abstract::The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent s...


    pub_type: 杂志文章


    authors: Chen J,Lee KH,Steinhauer DA,Stevens DJ,Skehel JJ,Wiley DC

    更新日期:1998-10-30 00:00:00

  • The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.

    abstract::The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally associates with a cohort of highly conserved cofactors to form a macromolecular complex that includes menin, a product of the MEN1 tumor suppressor ...


    pub_type: 杂志文章


    authors: Yokoyama A,Somervaille TC,Smith KS,Rozenblatt-Rosen O,Meyerson M,Cleary ML

    更新日期:2005-10-21 00:00:00

  • Reviving the exosome.

    abstract::In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et...


    pub_type: 评论,杂志文章


    authors: Jensen TH,Moore C

    更新日期:2005-06-03 00:00:00

  • The Identity of Human Tissue-Emigrant CD8+ T Cells.

    abstract::Lymphocyte migration is essential for adaptive immune surveillance. However, our current understanding of this process is rudimentary, because most human studies have been restricted to immunological analyses of blood and various tissues. To address this knowledge gap, we used an integrated approach to characterize ti...


    pub_type: 杂志文章


    authors: Buggert M,Vella LA,Nguyen S,Wu VH,Chen Z,Sekine T,Perez-Potti A,Maldini CR,Manne S,Darko S,Ransier A,Kuri-Cervantes L,Japp AS,Brody IB,Ivarsson MA,Gorin JB,Rivera-Ballesteros O,Hertwig L,Antel JP,Johnson ME,Okoye

    更新日期:2020-12-23 00:00:00