Drosophila p53 binds a damage response element at the reaper locus.

abstract：:Fragile X syndrome (FXS), the leading monogenic cause of intellectual disability and autism, results from loss of function of the RNA-binding protein FMRP. Here, we show that FMRP regulates translation of neuronal nitric oxide synthase 1 (NOS1) in the developing human neocortex. Whereas NOS1 mRNA is widely expressed, ...

journal_title：Cell

authors： Kwan KY,Lam MM,Johnson MB,Dube U,Shim S,Rašin MR,Sousa AM,Fertuzinhos S,Chen JG,Arellano JI,Chan DW,Pletikos M,Vasung L,Rowitch DH,Huang EJ,Schwartz ML,Willemsen R,Oostra BA,Rakic P,Heffer M,Kostović I,Judaš M,

更新日期：2012-05-11 00:00:00

abstract：:Adult skeletal muscle generates force in a controlled and directed manner through the contraction of highly specialized, postmitotic, multinucleated myofibers. Life-long muscle function relies on maintenance and regeneration of myofibers through a highly regulated process beginning with activation of normally quiescen...

journal_title：Cell

authors： Wagers AJ,Conboy IM

更新日期：2005-09-09 00:00:00

abstract：:Cholera toxin is assembled from two subunits in the periplasm of Vibrio cholerae and disassembled in the analogous compartment of target cells, the lumen of the endoplasmic reticulum (ER), before a fragment of it, the A1 chain, is transported into the cytosol. We show that protein disulfide isomerase (PDI) in the ER l...

journal_title：Cell

authors： Tsai B,Rodighiero C,Lencer WI,Rapoport TA

更新日期：2001-03-23 00:00:00

abstract：:DNA fragments containing the silencers that flank the mating type genes at HML alpha are shown to bind specifically to the nuclear scaffold of yeast. The scaffold proteins are solubilized with urea and then renatured to form a soluble extract which allows reconstitution of sequence-specific DNA loops. At the silent ma...

journal_title：Cell

authors： Hofmann JF,Laroche T,Brand AH,Gasser SM

更新日期：1989-06-02 00:00:00

abstract：:A plasmid, pHR402, containing SV40 sequences that include a truncated early region bearing an intact t-coding sequence and a functionally intact late region, was introduced into thymidine kinase deficient (tk-) mouse L cells by cotransformation with a cloned tk gene. tk+ cotransformants synthesized SV40 t but not T an...

journal_title：Cell

authors： Rubin H,Figge J,Bladon MT,Chen LB,Ellman M,Bikel I,Farrell M,Livingston DM

更新日期：1982-09-01 00:00:00

abstract：:Telomeres of Oxytricha nova macronuclear chromosomes consist of a repeated T4G4 sequence, single-stranded at the 3' terminus, bound by a heterodimeric protein. The cloning of genes for the two polypeptides and their separate expression in E. coli have enabled evaluation of their individual contributions to DNA binding...

journal_title：Cell

authors： Gray JT,Celander DW,Price CM,Cech TR

更新日期：1991-11-15 00:00:00

abstract：:Sensory transduction in E. coli consists of two phases, excitation and adaptation, both of which involve the methyl-accepting chemotaxis proteins (MCPs). These molecules relay transmembrane signals and are reversibly methylated during adaptation of E. coli to environmental stimuli. Each MCP contains multiple sites of ...

journal_title：Cell

authors： Kehry MR,Dahlquist FW

更新日期：1982-07-01 00:00:00

abstract：:Methylation of deoxycytidine incorporated by DNA excision-repair was studied in human diploid fibroblasts following damage with ultraviolet radiation, N-methyl-N-nitrosourea, or N-acetoxy-2-acetylaminofluorene. In confluent, nondividing cells, methylation in repair patches induced by all three agents is slow and incom...

journal_title：Cell

authors： Kastan MB,Gowans BJ,Lieberman MW

更新日期：1982-09-01 00:00:00

abstract：:Xenopus laevis oocytes were used as a model system to study the intracellular fate of proteins incorporated by endocytosis. We found that the intracellular stability and compartmentation of proteins incorporated by receptor-mediated endocytosis differed substantially from that of proteins incorporated by nonspecific e...

journal_title：Cell

authors： Opresko L,Wiley HS,Wallace RA

更新日期：1980-11-01 00:00:00

abstract：:Temperature compensation of circadian clocks is an unsolved problem with relevance to the general phenomenon of biological compensation. We identify casein kinase 2 (CK2) as a key regulator of temperature compensation of the Neurospora clock by determining that two long-standing clock mutants, chrono and period-3, dis...

journal_title：Cell

authors： Mehra A,Shi M,Baker CL,Colot HV,Loros JJ,Dunlap JC

更新日期：2009-05-15 00:00:00

abstract：:Given the heterogeneity of senescent cells, our knowledge of both the drivers and consequences of cellular senescence in tissues and organs remains limited, as is our understanding of how this process could be harnessed for human health. Here we identified five broad areas that would help propel the field forward. ...

journal_title：Cell

authors： Roy AL,Sierra F,Howcroft K,Singer DS,Sharpless N,Hodes RJ,Wilder EL,Anderson JM

更新日期：2020-11-25 00:00:00

abstract：:Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that ...

journal_title：Cell

authors： Hall AC,Lucas FR,Salinas PC

更新日期：2000-03-03 00:00:00

abstract：:Metagenomics seeks to characterize the composition of microbial communities, their operations, and their dynamically coevolving relationships with the habitats they occupy without having to culture community members. Uniting metagenomics with analyses of the products of microbial community metabolism (metabolomics) wi...

journal_title：Cell

authors： Turnbaugh PJ,Gordon JI

更新日期：2008-09-05 00:00:00

abstract：:To study the insertion of multispanning membrane proteins into the endoplasmic reticulum, we constructed novel proteins on the cDNA level by repeating, up to four times, the internal signal-anchor domain of the asialoglycoprotein receptor H1. Upon in vitro translation in the presence of microsomes, these polypeptides ...

journal_title：Cell

authors： Wessels HP,Spiess M

更新日期：1988-10-07 00:00:00

abstract：:Sucrose gradient analysis of DNA isolated from detergent-pronase lysates of adult flies has been used to look for ribosomal genes not integrated into the DNA of the chromosome in genotypes containing various combinations of inversions having breakpoints in the proximal heterochromatin of the X chromosome. Unintegrated...

journal_title：Cell

authors： Harford AG,Zuchowski CI

更新日期：1977-06-01 00:00:00

abstract：:It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF is required for tumor cell proliferation in a cell-autonomous and angiogenesis-independent manner. VEGF is upregulated in SO...

journal_title：Cell

authors： Lichtenberger BM,Tan PK,Niederleithner H,Ferrara N,Petzelbauer P,Sibilia M

更新日期：2010-01-22 00:00:00

abstract：:Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy. The interactions between the immune system and cancer ...

journal_title：Cell

authors： Sharma P,Hu-Lieskovan S,Wargo JA,Ribas A

更新日期：2017-02-09 00:00:00

abstract：:Trigger factor is a soluble, 63,000 dalton protein of E. coli that stabilizes proOmpA, the precursor form of a major outer-membrane protein, in a conformation competent for in vitro membrane assembly. There is approximately one trigger factor molecule bound to each 70S ribosome isolated from cell extracts in physiolog...

journal_title：Cell

authors： Lill R,Crooke E,Guthrie B,Wickner W

更新日期：1988-09-23 00:00:00

abstract：:Plants rely heavily on environmental cues to control the timing of developmental transitions. We are beginning to better understand what determines the timing of two of these transitions, the switch from juvenile to adult vegetative development and the transition to flowering. In this review, we discuss how RNA silenc...

journal_title：Cell

authors： Bäurle I,Dean C

更新日期：2006-05-19 00:00:00

abstract：:In prokaryotes, the toxin-antitoxin systems are thought to play important roles in growth regulation under stress conditions. In the E. coli MazE-MazF system, MazF toxin functions as an mRNA interferase cleaving mRNAs at ACA sequences to inhibit protein synthesis leading to cell growth arrest. Myxococcus xanthus is a ...

journal_title：Cell

authors： Nariya H,Inouye M

更新日期：2008-01-11 00:00:00

abstract：:Morphogen gradients control body pattern by differentially regulating cellular behavior. Here, we analyze the molecular events underlying the primary response to the Dpp/BMP morphogen in Drosophila. Throughout development, Dpp transduction causes the graded transcriptional downregulation of the brinker (brk) gene. We ...

journal_title：Cell

authors： Müller B,Hartmann B,Pyrowolakis G,Affolter M,Basler K

更新日期：2003-04-18 00:00:00

abstract：:X-ray studies have established that the structure of a right-handed, Watson-Crick double helix can change from place to place along its length as a function of base sequence. The base pairs transmit deformations out to the phosphate backbone, where they can then be recognized by proteins and other DNA-binding reagents...

journal_title：Cell

authors： Drew HR,Travers AA

更新日期：1984-06-01 00:00:00

abstract：:The C-terminal domain (CTD) of the largest subunit of yeast RNA polymerase II contains 26-27 tandem copies of a conserved heptapeptide of unknown function. Yeast strains whose CTD contains ten heptamers are viable but defective for transcription of the INO1 gene and cold sensitive for growth. Deletion of the SIN1 gene...

journal_title：Cell

authors： Peterson CL,Kruger W,Herskowitz I

更新日期：1991-03-22 00:00:00

abstract：:A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...

journal_title：Cell

authors： Wilson VL,Jones PA

更新日期：1983-01-01 00:00:00

abstract：:We have isolated cDNA clones encoding the four different forms of mouse myelin basic protein (MBP) and have analyzed the structure of the MBP gene. The three larger forms of MBP differ from the smallest by the inclusion of either or both of two short amino acid sequences at positions 57 and 124 of the smallest protein...

journal_title：Cell

authors： de Ferra F,Engh H,Hudson L,Kamholz J,Puckett C,Molineaux S,Lazzarini RA

更新日期：1985-12-01 00:00:00

abstract：:The human epsilon-globin gene has a number of alternative transcription-initiation sites located upstream of the canonical mRNA cap site. In three nonerythroid cell lines, "leaky" epsilon-globin transcription occurs exclusively from one of these upstream sites, the -200 cap site. Using a transient expression assay, we...

journal_title：Cell

authors： Allan M,Zhu JD,Montague P,Paul J

更新日期：1984-09-01 00:00:00

abstract：:Much of our understanding of chromosome segregation is based on cell culture systems. Here, we examine the importance of the tissue environment for chromosome segregation by comparing chromosome segregation fidelity across several primary cell types in native and nonnative contexts. We discover that epithelial cells h...

journal_title：Cell

authors： Knouse KA,Lopez KE,Bachofner M,Amon A

更新日期：2018-09-20 00:00:00

abstract：:Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been elucidated. Here, we discovered an unexpected role of the Hippo pathway in suppressing anti-tumor immunity. We demonstrate that, in three...

journal_title：Cell

authors： Moroishi T,Hayashi T,Pan WW,Fujita Y,Holt MV,Qin J,Carson DA,Guan KL

更新日期：2016-12-01 00:00:00

abstract：:Phage G1 gp67 is a 23 kDa protein that binds to the Staphylococcus aureus (Sau) RNA polymerase (RNAP) σ(A) subunit and blocks cell growth by inhibiting transcription. We show that gp67 has little to no effect on transcription from most promoters but is a potent inhibitor of ribosomal RNA transcription. A 2.0-Å-resolut...

journal_title：Cell

authors： Osmundson J,Montero-Diez C,Westblade LF,Hochschild A,Darst SA

更新日期：2012-11-21 00:00:00

abstract：:The global financial crisis has hit biotech companies hard both in the US and Europe as venture capital dries up. Finding new sources of long-term financing for translating research into new therapeutics will be essential for maintaining innovation and new drug development by biotech companies. ...

journal_title：Cell

authors： Karberg S

更新日期：2009-08-07 00:00:00