A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1.

abstract：:The v-erbB gene of avian erythroblastosis virus (AEV) codes for an integral plasma membrane glycoprotein, gp74erbB. Expression of gp74erbB and its intracellular precursors, gp66erbB and gp68erbB, has been studied in cells transformed by two temperature-sensitive mutants of AEV. After shift to 42 degrees C, the process...

journal_title：Cell

authors： Beug H,Hayman MJ

更新日期：1984-04-01 00:00:00

abstract：:The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity ...

journal_title：Cell

authors： Struhl G,Fitzgerald K,Greenwald I

更新日期：1993-07-30 00:00:00

abstract：:The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiquitin-conjugating enzymes to assemble polyubiquitin chains on proteins important for cell-cycle progression. It remains unclear how the APC - or many other E3s - promotes the multiple distinct reactions ...

journal_title：Cell

authors： Rodrigo-Brenni MC,Morgan DO

更新日期：2007-07-13 00:00:00

abstract：:Meiotic recombination occurs preferentially between homologous nonsister chromatids rather than between sisters, opposite to the bias of mitotic recombinational repair. We have examined formation of joint molecule recombination intermediates (JMs) between homologs and between sisters in yeast strains lacking the meiot...

journal_title：Cell

authors： Schwacha A,Kleckner N

更新日期：1997-09-19 00:00:00

abstract：:This year, the Lasker Foundation confers its Clinical Medical Research Award on Akira Endo for his isolation from fungi of statins, potent inhibitors of cholesterol synthesis in the liver. The introduction of statins to clinical practice has markedly reduced morbidity and mortality from atherosclerotic cardiovascular ...

journal_title：Cell

authors： Stossel TP

更新日期：2008-09-19 00:00:00

abstract：:Mutations in the Drosophila maternal genes plutonium (plu) and pan gu (png) have the striking phenotype that DNA replication initiates in unfertilized eggs. Fertilized eggs from plu or png mutant mothers also have a mutant phenotype; DNA replication is uncoupled from nuclear division, resulting in giant, polyploid nuc...

journal_title：Cell

authors： Shamanski FL,Orr-Weaver TL

更新日期：1991-09-20 00:00:00

abstract：:Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system. ...

journal_title：Cell

authors： Ma A

更新日期：2007-10-05 00:00:00

abstract：:Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement. Although components of this pathway have been previously generated and studied in vitro, the assembly of this multi-synaptic circuit has not yet been achieved with human cells. Here...

journal_title：Cell

authors： Andersen J,Revah O,Miura Y,Thom N,Amin ND,Kelley KW,Singh M,Chen X,Thete MV,Walczak EM,Vogel H,Fan HC,Paşca SP

更新日期：2020-12-23 00:00:00

abstract：:The liver is capable of completely regenerating itself in response to injury and after partial hepatectomy. In liver of old animals, the proliferative response is dramatically reduced, the mechanism for which is unknown. The liver specific protein, C/EBPalpha, normally arrests proliferation of hepatocytes through inhi...

journal_title：Cell

authors： Iakova P,Awad SS,Timchenko NA

更新日期：2003-05-16 00:00:00

abstract：:Mitochondrial DNA replication was examined in mutants for seven different Saccharomyces cerevisiae genes which are essential for nuclear DNA replication. In cdc8 and cdc21, mutants defective in continued replication during the S phase of the cell cycle, mitochondrial DNA replication ceases at the nonpermissive tempera...

journal_title：Cell

authors： Newlon CS,Fangman WL

更新日期：1975-08-01 00:00:00

abstract：:We have investigated the in vivo functional role of rab5, a small GTPase associated with the plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein defective in GTP binding, was overexpressed in baby hamster kidney cells. In cells expressing the rab5ile 133 protein, the rate of endocytosi...

journal_title：Cell

authors： Bucci C,Parton RG,Mather IH,Stunnenberg H,Simons K,Hoflack B,Zerial M

更新日期：1992-09-04 00:00:00

abstract：:We have reconstituted the fusion and assembly of vesiculated Golgi membranes (VGMs) into functionally active stacks of cisternae. A kinetic analysis of this assembly process revealed that highly dispersed VGMs of 60-90 nm diameter first fuse to form larger vesicles of 200-300 nm diameter that are clustered together. T...

journal_title：Cell

authors： Acharya U,Jacobs R,Peters JM,Watson N,Farquhar MG,Malhotra V

更新日期：1995-09-22 00:00:00

abstract：:We have analyzed the viral DNA sequences persisting in HE C19, a clonal line of hamster embryo cells transformed in vitro by human adenovirus 12 (Ad 12), a member of highly oncogenic group A. Saturation-hybridization of in vitro labeled Ad 12 DNA (2-4 x 10(8) cpm/mug) with HE C19 DNA showed that 93-100% of viral DNA s...

journal_title：Cell

authors： Green MR,Chinnadurai G,Mackey JK,Green M

更新日期：1976-03-01 00:00:00

abstract：:The pluripotential hemopoietic stem cells (CFU-S) of genetically resistant Fv2rr adult C57BL/6 (B6) mice can be persistently infected by Friend virus (FV) when exposed to defective spleen focus-forming virus (SFFV) and helper virus (LLV) at the time of transplantation into heavily irradiated syngeneic recipients (that...

journal_title：Cell

authors： Eckner RJ,Hettrick KL,Greenberger JS,Bennett M

更新日期：1982-12-01 00:00:00

abstract：:Interactions between transcription factors bound to separate operator sites commonly play an important role in gene regulation by mediating cooperative binding to the DNA. However, few detailed structural models for understanding the molecular basis of such cooperativity are available. The c1 repressor of bacteriophag...

journal_title：Cell

authors： Bell CE,Frescura P,Hochschild A,Lewis M

更新日期：2000-06-23 00:00:00

abstract：:Misfolded proteins accumulating in several neurodegenerative diseases (including Alzheimer, Parkinson, and Huntington diseases) can cause aggregation of their native counterparts through a mechanism similar to the infectious prion protein's induction of a pathogenic conformation onto its cellular isoform. Evidence for...

journal_title：Cell

authors： Polymenidou M,Cleveland DW

更新日期：2011-10-28 00:00:00

abstract：:Two studies from Jarosz et al. describe how [GAR(+)], a protein-based epigenetic determinant found mainly in wild yeast strains, can be activated by microbial cross-kingdom communication. With the aid of genetically and ecologically diverse bacteria, yeast can override an ancient regulatory mechanism of glucose repres...

journal_title：Cell

authors： Staniforth GL,Tuite MF

更新日期：2014-08-28 00:00:00

abstract：:The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene essentiality dataset across 14 human acute myeloid leukemia (AML) ce...

journal_title：Cell

authors： Wang T,Yu H,Hughes NW,Liu B,Kendirli A,Klein K,Chen WW,Lander ES,Sabatini DM

更新日期：2017-02-23 00:00:00

abstract：:To determine whether phylogenetically conservative H-Y antigen plays any part in gonadal differentiation among the nonmammalian vertebrates, we studied expression and binding of H-Y in the frog, Xenopus laevis. Soluble H-Y obtained from mouse testis and soluble H-W from chicken ovary bound specifically to cells of the...

journal_title：Cell

authors： Wachtel SS,Bresler PA,Koide SS

更新日期：1980-07-01 00:00:00

abstract：:It was previously demonstrated that the 60,000 dalton (p60) precursor-like polyprotein containing murine p30 was a constituent of the feline leukemia virus pseudotype of Moloney sarcoma virus [m1MSV(FeLV)]. It is now shown that p60 is detected in cells of five mammalian species transformed by m1MSV, indicating that p...

journal_title：Cell

authors： Robey WG,Oskarsson MK,Vande Woude GF,Naso RB,Arlinghaus RB,Haapala DK,Fischinger PJ

更新日期：1977-01-01 00:00:00

abstract：:T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4+ T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83-/-) mice had a specific block in CD4+ single-positive thymocyte development with...

journal_title：Cell

authors： Fujimoto Y,Tu L,Miller AS,Bock C,Fujimoto M,Doyle C,Steeber DA,Tedder TF

更新日期：2002-03-22 00:00:00

abstract：:Lipid composition affects the biophysical properties of membranes that provide a platform for receptor-mediated cellular signaling. To study the regulatory role of membrane lipid composition, we combined genetic perturbations of sphingolipid metabolism with the quantification of diverse steps in Toll-like receptor (TL...

journal_title：Cell

authors： Köberlin MS,Snijder B,Heinz LX,Baumann CL,Fauster A,Vladimer GI,Gavin AC,Superti-Furga G

更新日期：2015-07-02 00:00:00

abstract：:The crystal structure of the Src SH2 domain complexed with a high affinity 11-residue phosphopeptide has been determined at 2.7 A resolution by X-ray diffraction. The peptide binds in an extended conformation and makes primary interactions with the SH2 domain at six central residues: PQ(pY)EEI. The phosphotyrosine and...

journal_title：Cell

authors： Waksman G,Shoelson SE,Pant N,Cowburn D,Kuriyan J

更新日期：1993-03-12 00:00:00

abstract：:The rapid cell proliferation characteristic of early animal embryos is accomplished with an abbreviated cell cycle and no DNA replication checkpoint. Blythe and Wieschaus provide evidence that nascent zygotic transcription precedes—and may trigger—this checkpoint at the midblastula transition. ...

journal_title：Cell

authors： Laver JD,Lipshitz HD

更新日期：2015-03-12 00:00:00

abstract：:Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis....

journal_title：Cell

authors： Fredrick K,Ibba M

更新日期：2010-04-16 00:00:00

abstract：:The modularity of protein architecture and the diversity of protein domains hint at a vast combinatorial richness. But evolution appears to have been relatively conservative about selecting new combinations. When a particular grouping of domains within a polypeptide chain can perform a concerted function, that combina...

journal_title：Cell

authors： Harrison SC

更新日期：2003-03-21 00:00:00

abstract：:Upon exposure to 0.1 mM N-phosphonacetyl-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, most cells of a simian virus 40 (SV40)-transformed Syrian hamster line are killed within a few days, but resistant mutants form spontaneously with frequency 2-5 X 10(-5) in a stochastic proce...

journal_title：Cell

authors： Kempe TD,Swyryd EA,Bruist M,Stark GR

更新日期：1976-12-01 00:00:00

abstract：:The fovea is a specialized region of the retina that dominates the visual perception of primates by providing high chromatic and spatial acuity. While the foveal and peripheral retina share a similar core circuit architecture, they exhibit profound functional differences whose mechanisms are unknown. Using intracellul...

journal_title：Cell

authors： Sinha R,Hoon M,Baudin J,Okawa H,Wong ROL,Rieke F

更新日期：2017-01-26 00:00:00

abstract：:Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target gen...

journal_title：Cell

authors： Piccolo S

更新日期：2008-05-30 00:00:00

abstract：:We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED-3 protein shows similarity to human and murine interleukin-1 beta-converting enzyme and to the product of the mouse nedd-2 gene, whi...

journal_title：Cell

authors： Yuan J,Shaham S,Ledoux S,Ellis HM,Horvitz HR

更新日期：1993-11-19 00:00:00