Abstract：
:The fovea is a specialized region of the retina that dominates the visual perception of primates by providing high chromatic and spatial acuity. While the foveal and peripheral retina share a similar core circuit architecture, they exhibit profound functional differences whose mechanisms are unknown. Using intracellular recordings and structure-function analyses, we examined the cellular and synaptic underpinnings of the primate fovea. Compared to peripheral vision, the fovea displays decreased sensitivity to rapid variations in light inputs; this difference is reflected in the responses of ganglion cells, the output cells of the retina. Surprisingly, and unlike in the periphery, synaptic inhibition minimally shaped the responses of foveal midget ganglion cells. This difference in inhibition cannot however, explain the differences in the temporal sensitivity of foveal and peripheral midget ganglion cells. Instead, foveal cone photoreceptors themselves exhibited slower light responses than peripheral cones, unexpectedly linking cone signals to perceptual sensitivity.
journal_name
Celljournal_title
Cellauthors
Sinha R,Hoon M,Baudin J,Okawa H,Wong ROL,Rieke Fdoi
10.1016/j.cell.2017.01.005subject
Has Abstractpub_date
2017-01-26 00:00:00pages
413-426.e12issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(17)30053-3journal_volume
168pub_type
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