Breast cancer stem cells: eradication by differentiation therapy?

abstract：:The mec-3 gene is essential for proper differentiation of the set of six touch receptor neurons in C. elegans. In mutants lacking mec-3 activity, the touch receptors express none of their unique differentiated features and appear to be transformed into other types of neurons. We cloned the mec-3 gene by transposon tag...

journal_title：Cell

authors： Way JC,Chalfie M

更新日期：1988-07-01 00:00:00

abstract：:We have performed in vitro kinetic analyses of transcription from the 5S gene promoter in order to resolve the rate-limiting events which lead to accurate transcription of the 5S RNA gene. We demonstrate that a rate-limiting intermediate can be formed during an extended incubation prior to initiation of transcription....

journal_title：Cell

authors： Bieker JJ,Martin PL,Roeder RG

更新日期：1985-01-01 00:00:00

abstract：:Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen. Histone chaperones (Chaf1a/b), sumoylation factors ...

journal_title：Cell

authors： Yang BX,El Farran CA,Guo HC,Yu T,Fang HT,Wang HF,Schlesinger S,Seah YF,Goh GY,Neo SP,Li Y,Lorincz MC,Tergaonkar V,Lim TM,Chen L,Gunaratne J,Collins JJ,Goff SP,Daley GQ,Li H,Bard FA,Loh YH

更新日期：2015-09-24 00:00:00

abstract：:Cloned, sequenced mouse satellite DNA exhibits properties characteristic of molecules that possess a stable curvature. Circularly permuted fragments containing the region predicted to bend were used to map the curvature relative to DNA sequence. The altered mobility of these fragments in polyacrylamide gels is reverse...

journal_title：Cell

authors： Radic MZ,Lundgren K,Hamkalo BA

更新日期：1987-09-25 00:00:00

abstract：:In April this year, a new influenza virus of swine origin emerged in Mexico and spread rapidly around the world. As the Northern hemisphere winter flu season kicks off, Laura Vargas-Parada reports on the measures that Mexico is taking to combat the H1N1 pandemic. ...

journal_title：Cell

authors： Vargas-Parada L

更新日期：2009-12-24 00:00:00

abstract：:The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...

journal_title：Cell

authors： Heindell HC,Liu A,Paddock GV,Studnicka GM,Salser WA

更新日期：1978-09-01 00:00:00

abstract：:Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion efficiency and failure o...

journal_title：Cell

authors： Zhou H,Su J,Hu X,Zhou C,Li H,Chen Z,Xiao Q,Wang B,Wu W,Sun Y,Zhou Y,Tang C,Liu F,Wang L,Feng C,Liu M,Li S,Zhang Y,Xu H,Yao H,Shi L,Yang H

更新日期：2020-04-30 00:00:00

abstract：:Epigenetic inheritance is more widespread in plants than in mammals, in part because mammals erase epigenetic information by germline reprogramming. We sequenced the methylome of three haploid cell types from developing pollen: the sperm cell, the vegetative cell, and their precursor, the postmeiotic microspore, and f...

journal_title：Cell

authors： Calarco JP,Borges F,Donoghue MT,Van Ex F,Jullien PE,Lopes T,Gardner R,Berger F,Feijó JA,Becker JD,Martienssen RA

更新日期：2012-09-28 00:00:00

abstract：:Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...

journal_title：Cell

authors： Rodriguez-Romaguera J,Stuber GD

更新日期：2018-05-17 00:00:00

abstract：:The v-erbB gene of avian erythroblastosis virus (AEV) codes for an integral plasma membrane glycoprotein, gp74erbB. Expression of gp74erbB and its intracellular precursors, gp66erbB and gp68erbB, has been studied in cells transformed by two temperature-sensitive mutants of AEV. After shift to 42 degrees C, the process...

journal_title：Cell

authors： Beug H,Hayman MJ

更新日期：1984-04-01 00:00:00

abstract：:A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between different lineages of stem cells are crucial for hair follicle growth and cycling and point to a compl...

journal_title：Cell

authors： Jahoda CA,Christiano AM

更新日期：2011-09-02 00:00:00

abstract：:Two DNA sequences that reduce mitotic fidelity of chromosome transmission have been identified: MIF1 and MIF2. MIF1 is a unique sequence located on the right arm of chromosome XII that stimulates loss and recombination for both chromosomes V and VII when present in a high copy number plasmid. MIF1 is not essential for...

journal_title：Cell

authors： Meeks-Wagner D,Wood JS,Garvik B,Hartwell LH

更新日期：1986-01-17 00:00:00

abstract：:Anterograde transport in the early secretory pathway is mediated by COPII-coated vesicles. Stagg et al. (2008) have now visualized the double-layered COPII coat using electron cryomicroscopy, providing insight into how coats are assembled to accommodate cargo of different sizes. ...

journal_title：Cell

authors： Hughson FM

更新日期：2008-08-08 00:00:00

abstract：:We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

journal_title：Cell

authors： Thomas KR,Capecchi MR

更新日期：1987-11-06 00:00:00

abstract：:Here we characterize the T-cell-activating protein (TAP), an Ly-6 gene product involved in T cell activation, as a glycoprotein with a molecular weight of 10-12 kd under nonreducing conditions and 15-18 kd under reducing ones. Two of the three bands that are precipitated from metabolically labeled cells are expressed ...

journal_title：Cell

authors： Reiser H,Oettgen H,Yeh ET,Terhorst C,Low MG,Benacerraf B,Rock KL

更新日期：1986-11-07 00:00:00

abstract：:Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ...

journal_title：Cell

authors： Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popović B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpotić A,Allan DSJ,Makrigiannis AP,Jonjić S,Rossjohn J,Carlyle JR

更新日期：2017-03-23 00:00:00

abstract：:To study the insertion of multispanning membrane proteins into the endoplasmic reticulum, we constructed novel proteins on the cDNA level by repeating, up to four times, the internal signal-anchor domain of the asialoglycoprotein receptor H1. Upon in vitro translation in the presence of microsomes, these polypeptides ...

journal_title：Cell

authors： Wessels HP,Spiess M

更新日期：1988-10-07 00:00:00

abstract：:We used clinical tissue from lethal metastatic castration-resistant prostate cancer (CRPC) patients obtained at rapid autopsy to evaluate diverse genomic, transcriptomic, and phosphoproteomic datasets for pathway analysis. Using Tied Diffusion through Interacting Events (TieDIE), we integrated differentially expressed...

journal_title：Cell

authors： Drake JM,Paull EO,Graham NA,Lee JK,Smith BA,Titz B,Stoyanova T,Faltermeier CM,Uzunangelov V,Carlin DE,Fleming DT,Wong CK,Newton Y,Sudha S,Vashisht AA,Huang J,Wohlschlegel JA,Graeber TG,Witte ON,Stuart JM

更新日期：2016-08-11 00:00:00

abstract：:We have shown previously that the putative oncogene pim-1 is frequently activated by provirus insertion in murine leukemia virus-induced T cell lymphomas. Here we describe the structure of the pim-1 gene as determined by sequencing genomic and cDNA clones. The gene has an open reading frame, encoding a protein of 313 ...

journal_title：Cell

authors： Selten G,Cuypers HT,Boelens W,Robanus-Maandag E,Verbeek J,Domen J,van Beveren C,Berns A

更新日期：1986-08-15 00:00:00

abstract：:The specificity of target gene activation by steroid receptors is encoded within a small, cysteine-rich domain that is believed to form two zinc-coordinated fingers. Here we show that the ability of glucocorticoid and estrogen receptors to discriminate between their closely related response elements resides in the two...

journal_title：Cell

authors： Danielsen M,Hinck L,Ringold GM

更新日期：1989-06-30 00:00:00

abstract：:The 5' terminal structure of the mRNA synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus in the presence of S-adenosyl-L-methione consists of 7-methyl guanosine linked to 2'-O-methyl adenosine through a 5'-5' pyrophosphate bond as m7G(5')ppp(5')A-m-p ... The alpha and beta phosp...

journal_title：Cell

authors： Abraham G,Rhodes DP,Banerjee AK

更新日期：1975-05-01 00:00:00

abstract：:The short chain aliphatic acid salts, butyrate and propionate, are effective inhibitors of histone deacetylation in chick oviduct at 2--5 mM; they also prevent the hormonal induction of the ovalbumin and transferrin genes. The less potent deacetylase inhibitor isobutyrate is correspondingly less effective in blocking ...

journal_title：Cell

authors： McKnight GS,Hager L,Palmiter RD

更新日期：1980-11-01 00:00:00

abstract：:Muscle cell cultures from Drosophila melanogaster were obtained by plating dissociated gastrula stage embryo cells on protamine-treated culture dishes. They myogenic cells in these cultures fuse to form multinucleated pulsating cells by 15 hr after plating. An analysis of protein synthesis during myogenesis in these c...

journal_title：Cell

authors： Storti RV,Horovitch SJ,Scott MP,Rich A,Pardue ML

更新日期：1978-04-01 00:00:00

abstract：:Evasion of DNA damage-induced cell death, via mutation of the p53 tumor suppressor or overexpression of prosurvival Bcl-2 family proteins, is a key step toward malignant transformation and therapeutic resistance. We report that depletion or acute inhibition of checkpoint kinase 1 (Chk1) is sufficient to restore gamma-...

journal_title：Cell

authors： Sidi S,Sanda T,Kennedy RD,Hagen AT,Jette CA,Hoffmans R,Pascual J,Imamura S,Kishi S,Amatruda JF,Kanki JP,Green DR,D'Andrea AA,Look AT

更新日期：2008-05-30 00:00:00

abstract：:Inducer T-cell clones reactive to the p-azobenzenearsonate (arsonate) hapten possess binding sites for radioactive arsanylated proteins, which are not present on clones with other antigen specificities. Binding occurred in the absence of histocompatibility proteins. Binding was specific for the p-azobenzenearsonate ha...

journal_title：Cell

authors： Rao A,Ko WW,Faas SJ,Cantor H

更新日期：1984-04-01 00:00:00

abstract：:A distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious heat. Here ...

journal_title：Cell

authors： Peier AM,Moqrich A,Hergarden AC,Reeve AJ,Andersson DA,Story GM,Earley TJ,Dragoni I,McIntyre P,Bevan S,Patapoutian A

更新日期：2002-03-08 00:00:00

abstract：:Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice, this is because the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing V beta 3 and V beta 8.1, 8.2, and 8.3, and few oth...

journal_title：Cell

authors： White J,Herman A,Pullen AM,Kubo R,Kappler JW,Marrack P

更新日期：1989-01-13 00:00:00

abstract：:The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while increasing network excitability. In addition, loss of PKR i...

journal_title：Cell

authors： Zhu PJ,Huang W,Kalikulov D,Yoo JW,Placzek AN,Stoica L,Zhou H,Bell JC,Friedlander MJ,Krnjević K,Noebels JL,Costa-Mattioli M

更新日期：2011-12-09 00:00:00

abstract：:Striated muscle-specific disruption of the dystroglycan (DAG1) gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a remarkably mild muscular dystrophy with hypertrophy and without tissue fibrosis. We find that satellite cells, expressing dystroglycan, support continued efficient r...

journal_title：Cell

authors： Cohn RD,Henry MD,Michele DE,Barresi R,Saito F,Moore SA,Flanagan JD,Skwarchuk MW,Robbins ME,Mendell JR,Williamson RA,Campbell KP

更新日期：2002-09-06 00:00:00

abstract：:In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et...

journal_title：Cell

authors： Jensen TH,Moore C

更新日期：2005-06-03 00:00:00