Abstract:
:A distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious heat. Here we describe the cloning and characterization of TRPM8, a distant relative of VR1. TRPM8 is specifically expressed in a subset of pain- and temperature-sensing neurons. Cells overexpressing the TRPM8 channel can be activated by cold temperatures and by a cooling agent, menthol. Our identification of a cold-sensing TRP channel in a distinct subpopulation of sensory neurons implicates an expanded role for this family of ion channels in somatic sensory detection.
journal_name
Celljournal_title
Cellauthors
Peier AM,Moqrich A,Hergarden AC,Reeve AJ,Andersson DA,Story GM,Earley TJ,Dragoni I,McIntyre P,Bevan S,Patapoutian Adoi
10.1016/s0092-8674(02)00652-9subject
Has Abstractpub_date
2002-03-08 00:00:00pages
705-15issue
5eissn
0092-8674issn
1097-4172pii
S0092867402006529journal_volume
108pub_type
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