Abstract：
:Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, FH, and IDH can result in cancer and, more broadly, for how alterations in metabolism and nutrition might contribute to disease. Here, we review literature pertinent to hypothetical connections between metabolic and epigenetic states in eukaryotic cells.
journal_name
Celljournal_title
Cellauthors
Kaelin WG Jr,McKnight SLdoi
10.1016/j.cell.2013.03.004subject
Has Abstractpub_date
2013-03-28 00:00:00pages
56-69issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(13)00290-0journal_volume
153pub_type
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