Abstract：
:Neural progenitors generate distinct cell types at different stages, but the mechanisms controlling these temporal transitions are poorly understood. In the Drosophila CNS, a cascade of transcription factors, the "temporal gene cascade," has been identified that acts to alter progenitor competence over time. However, many CNS lineages display broad temporal windows, and it is unclear how broad windows progress into subwindows that generate unique cell types. We have addressed this issue in an identifiable Drosophila CNS lineage and find that a broad castor temporal window is subdivided by two different feed-forward loops, both of which are triggered by castor itself. The first loop acts to specify a unique cell fate, whereas the second loop suppresses the first loop, thereby allowing for the generation of alternate cell fates. This mechanism of temporal and "subtemporal" genes acting in opposing feed-forward loops may be used by many stem cell lineages to generate diversity.
journal_name
Celljournal_title
Cellauthors
Baumgardt M,Karlsson D,Terriente J,Díaz-Benjumea FJ,Thor Sdoi
10.1016/j.cell.2009.10.032subject
Has Abstractpub_date
2009-11-25 00:00:00pages
969-82issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(09)01358-0journal_volume
139pub_type
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