Abstract:
:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequences.
journal_name
Celljournal_title
Cellauthors
Licht JDdoi
10.1016/j.cell.2015.08.005subject
Has Abstractpub_date
2015-08-27 00:00:00pages
938-9issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(15)01018-1journal_volume
162pub_type
评论,杂志文章相关文献
CELL文献大全abstract::Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form of age-related macular degeneration that causes blindness in millions of individuals. The mechanism of Alu RNA-induced cytotoxicity is unknown. Here we show that DICER1 def...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.03.036
更新日期:2012-05-11 00:00:00
abstract::Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. Ongoing projects worldwide are sequencing many thousands-and soon millions-of huma...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2019.02.032
更新日期:2019-03-21 00:00:00
abstract::Expression of pipe in the somatic tissue of the Drosophila ovary is required for the formation of embryonic dorsal-ventral polarity. pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81615-3
更新日期:1998-11-13 00:00:00
abstract::K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras ancho...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.11.059
更新日期:2017-01-12 00:00:00
abstract::The rapid cell proliferation characteristic of early animal embryos is accomplished with an abbreviated cell cycle and no DNA replication checkpoint. Blythe and Wieschaus provide evidence that nascent zygotic transcription precedes—and may trigger—this checkpoint at the midblastula transition. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.02.051
更新日期:2015-03-12 00:00:00
abstract::xol-1 is the earliest-acting gene in the known hierarchy that controls C. elegans sex determination and dosage compensation. We show that the primary sex-determining signal (the X/A ratio) directs the choice of sexual fate by regulating xol-1 transcript levels: high xol-1 expression during gastrulation triggers male d...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90452-2
更新日期:1995-01-13 00:00:00
abstract::Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal signals across multiple neuronal cell types. Here, we combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.07.039
更新日期:2011-09-16 00:00:00
abstract::Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Al...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2010.02.016
更新日期:2010-03-19 00:00:00
abstract::Endogenous and infectious mouse mammary tumor viruses (MMTVs) encode in their 3' long terminal repeat a protein that exerts superantigen activity; that is, it is able to interact with T cells via the variable domain of the T cell receptor (TCR) beta chain. We show here that transmission of an infectious MMTV is preven...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)80054-i
更新日期:1993-08-13 00:00:00
abstract::Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-IoxP-mediated recombination, we demonstrate a critical role for a gp130-dependent myocyte survival pathway in the...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80729-1
更新日期:1999-04-16 00:00:00
abstract::Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are resistant to cardiac stress and have increased median lifespan of approximately 30%. AC5 KO mice are protected from red...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.05.038
更新日期:2007-07-27 00:00:00
abstract::Brefeldin A (BFA) is a fungal metabolite that causes a redistribution of the stacked cisternae of the Golgi complex into the endoplasmic reticulum by inhibiting anterograde transport. We report that BFA also causes membrane tubules derived from the trans-Golgi network (TGN) to fuse with early endosomes. In the presenc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90533-5
更新日期:1991-11-01 00:00:00
abstract::During neural tube closure and spinal cord development, many cells die in both the central and peripheral nervous systems (CNS and PNS, respectively). However, myeloid-derived professional phagocytes have not yet colonized the trunk region during early neurogenesis. How apoptotic cells are removed from this region dur...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.08.001
更新日期:2019-09-19 00:00:00
abstract::The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF com...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00446-9
更新日期:2001-08-10 00:00:00
abstract::Microbial populations can maximize fitness in dynamic environments through bet hedging, a process wherein a subpopulation assumes a phenotype not optimally adapted to the present environment but well adapted to an environment likely to be encountered. Here, we show that oxygen induces fluctuating expression of the tri...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.005
更新日期:2018-03-22 00:00:00
abstract::The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. Here, we report a pipeline for the rapid design, assembly, and validation of cell-free, paper-based sensors for the detection of the Zika virus RNA genome. By linking ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.04.059
更新日期:2016-05-19 00:00:00
abstract::The "protective protein" is a glycoprotein that associates with lysosomal beta-galactosidase and neuraminidase and is deficient in the autosomal recessive disorder galactosialidosis. We have isolated the cDNA encoding human "protective protein". The clone recognizes a 2 kb mRNA in normal cells that is not evident in f...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(88)90999-3
更新日期:1988-09-09 00:00:00
abstract::Subcellular compartments in which folding and assembly of proteins occur seem to have a set of PCB proteins capable of mediating these and related processes, such as translocation across membranes. When a domain of a polypeptide chain emerges from a ribosome during synthesis or from the distal side of a membrane durin...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/0092-8674(89)90005-6
更新日期:1989-11-17 00:00:00
abstract::At the replication origin of ColE1 plasmid, a persistent hybrid is formed between the primer precursor (RNA II) and its template DNA. The wild-type sequence in the region 13 to 20 bp upstream (-20 region) of the origin is required to form this persistent hybrid. While the template strand for transcription of this regi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90370-t
更新日期:1990-07-27 00:00:00
abstract::During fruiting body development, the product of the csgA gene is necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hr of starvation. From nascent wild-type fruiting bodies we have purified a polypeptide of 17 kd called C-factor, which, at approximately 1 ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90211-v
更新日期:1990-04-06 00:00:00
abstract::Polycomb group proteins control a hierarchy of gene expression during the differentiation of stem cells. In this issue, Ezhkova et al. (2009) show that repression mediated by Polycomb proteins controls the timing of differentiation of precursor cells of the epidermal lineage. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2009.03.004
更新日期:2009-03-20 00:00:00
abstract::It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF is required for tumor cell proliferation in a cell-autonomous and angiogenesis-independent manner. VEGF is upregulated in SO...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.12.046
更新日期:2010-01-22 00:00:00
abstract::The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue development that result in metamorphosis. To advance our understanding of the genetic regulatory hierarchies controlling this tissue response, we have isolated and characterized a gene, EcR, for a new steroid receptor homolog and have shown ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90572-g
更新日期:1991-10-04 00:00:00
abstract::The chaperonin GroEL binds nonnative proteins too large to fit inside the productive GroEL-GroES cis cavity, but whether and how it assists their folding has remained unanswered. We have examined yeast mitochondrial aconitase, an 82 kDa monomeric Fe(4)S(4) cluster-containing enzyme, observed to aggregate in chaperonin...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00523-2
更新日期:2001-10-19 00:00:00
abstract::It has been proposed that the initiator protein RepA is rate limiting for mini-P1 plasmid replication, and that the role of the plasmid copy number control locus is to sequester the initiator and thus reduce replication. This proposal appears inconsistent with the observation that RepA is autoregulated, since the prot...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90468-0
更新日期:1988-02-26 00:00:00
abstract::Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasion of new transposons. In Drosophila, piRNAs are encoded by heterochromatic clusters and maternally deposited in the embryo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.11.042
更新日期:2011-12-23 00:00:00
abstract::The intestinal microbiota produces tens of thousands of metabolites. Here, we used host sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate bioactive microbial metabolites that impact host physiology. We screened 144 human gut bacteria against the non-olfactory GPCRome and identif...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.03.036
更新日期:2019-05-16 00:00:00
abstract::Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain po...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.05.004
更新日期:2014-06-05 00:00:00
abstract::The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.03.035
更新日期:2020-04-16 00:00:00
abstract::Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) v...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.071
更新日期:2016-07-14 00:00:00