DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.

Abstract:

:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequences.

journal_name

Cell

journal_title

Cell

authors

Licht JD

doi

10.1016/j.cell.2015.08.005

subject

Has Abstract

pub_date

2015-08-27 00:00:00

pages

938-9

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(15)01018-1

journal_volume

162

pub_type

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