DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.


:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequences.






Licht JD




Has Abstract


2015-08-27 00:00:00
















  • Nonreciprocal exchange between alleles of the yeast mitochondrial 21S rRNA gene: kinetics and the involvement of a double-strand break.

    abstract::A 1.1 kb intron containing an open reading frame (ORF) in one allele (omega+) of the yeast mitochondrial 21S rRNA gene is nearly quantitatively inserted in crosses into a 21S rRNA allele lacking that intron (omega-). We have determined that this nonreciprocal exchange initiates soon after cells fuse to form zygotes an...


    pub_type: 杂志文章


    authors: Zinn AR,Butow RA

    更新日期:1985-04-01 00:00:00

  • Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.

    abstract::The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here, we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput single-cell RNA and VDJ sequencing of antigen-enriched B cells from 60 convalescent patients. From 8,558 antigen-binding IgG1+ clonotypes, 1...


    pub_type: 杂志文章


    authors: Cao Y,Su B,Guo X,Sun W,Deng Y,Bao L,Zhu Q,Zhang X,Zheng Y,Geng C,Chai X,He R,Li X,Lv Q,Zhu H,Deng W,Xu Y,Wang Y,Qiao L,Tan Y,Song L,Wang G,Du X,Gao N,Liu J,Xiao J,Su XD,Du Z,Feng Y,Qin C,Qin C

    更新日期:2020-07-09 00:00:00

  • Dystrophin: the protein product of the Duchenne muscular dystrophy locus.

    abstract::The protein product of the human Duchenne muscular dystrophy locus (DMD) and its mouse homolog (mDMD) have been identified by using polyclonal antibodies directed against fusion proteins containing two distinct regions of the mDMD cDNA. The DMD protein is shown to be approximately 400 kd and to represent approximately...


    pub_type: 杂志文章


    authors: Hoffman EP,Brown RH Jr,Kunkel LM

    更新日期:1987-12-24 00:00:00

  • Glia Get Neurons in Shape.

    abstract::Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...


    pub_type: 评论,杂志文章


    authors: Sun LO,Barres BA

    更新日期:2016-05-05 00:00:00

  • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

    abstract::Apoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis, development, and disease. The anti-apoptotic protein, Bcl-2, interacts with the evolutionarily conserved autophagy protein, Beclin 1. However, little is known about the functional significance of thi...


    pub_type: 杂志文章


    authors: Pattingre S,Tassa A,Qu X,Garuti R,Liang XH,Mizushima N,Packer M,Schneider MD,Levine B

    更新日期:2005-09-23 00:00:00

  • Biotech's perfect storm.

    abstract::The global financial crisis has hit biotech companies hard both in the US and Europe as venture capital dries up. Finding new sources of long-term financing for translating research into new therapeutics will be essential for maintaining innovation and new drug development by biotech companies. ...


    pub_type: 杂志文章


    authors: Karberg S

    更新日期:2009-08-07 00:00:00

  • Green genes-comparative genomics of the green branch of life.

    abstract::As more plant genome sequences become available, researchers are increasingly using comparative genomics to address some of the major questions in plant biology. Such questions include the evolution of photosynthesis and multicellularity, the developmental genetic changes responsible for alterations in body plan, and ...


    pub_type: 杂志文章


    authors: Bowman JL,Floyd SK,Sakakibara K

    更新日期:2007-04-20 00:00:00

  • Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression.

    abstract::Beta-arrestin1 is a multifunctional protein critically involved in signal transduction. Recently, it is also identified as a nuclear transcriptional regulator, but the underlying mechanisms and physiological significance remain to be explored. Here, we identified beta-arrestin1 as an evolutionarily conserved protein e...


    pub_type: 杂志文章


    authors: Yue R,Kang J,Zhao C,Hu W,Tang Y,Liu X,Pei G

    更新日期:2009-10-30 00:00:00

  • Modeling Rett syndrome with stem cells.

    abstract::The discovery that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) raised the exciting possibility of modeling diseases with patient-specific cells. Marchetto et al. (2010) now use iPSC technology to generate, characterize, and treat an in vitro model for the autism spectrum disorder Rett...


    pub_type: 评论,杂志文章


    authors: Walsh RM,Hochedlinger K

    更新日期:2010-11-12 00:00:00

  • Curvature of mouse satellite DNA and condensation of heterochromatin.

    abstract::Cloned, sequenced mouse satellite DNA exhibits properties characteristic of molecules that possess a stable curvature. Circularly permuted fragments containing the region predicted to bend were used to map the curvature relative to DNA sequence. The altered mobility of these fragments in polyacrylamide gels is reverse...


    pub_type: 杂志文章


    authors: Radic MZ,Lundgren K,Hamkalo BA

    更新日期:1987-09-25 00:00:00

  • Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.

    abstract::Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs and direct posttranscriptional gene regulation. A final posttranscriptional step in gene expression is the turnover of the mRNP, which involves degradation of the mRNA and recycling of assoc...


    pub_type: 杂志文章


    authors: Franks TM,Singh G,Lykke-Andersen J

    更新日期:2010-12-10 00:00:00

  • S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase.

    abstract::Following DNA replication, eukaryotic cells must biorient all sister chromatids prior to cohesion cleavage at anaphase. In animal cells, sister chromatids gradually biorient during prometaphase, but current models of mitosis in S. cerevisiae assume that biorientation is established shortly after S phase. This assumpti...


    pub_type: 杂志文章


    authors: Marco E,Dorn JF,Hsu PH,Jaqaman K,Sorger PK,Danuser G

    更新日期:2013-08-29 00:00:00

  • Role of Drosophila alpha-adaptin in presynaptic vesicle recycling.

    abstract::Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...


    pub_type: 杂志文章


    authors: González-Gaitán M,Jäckle H

    更新日期:1997-03-21 00:00:00

  • The initiation of SV40 DNA synthesis is not unique to the replication origin.

    abstract::Replicative intermediates of SV40 were isolated, digested with the restriction endonuclease Bgl I and examined by electron microscopy. Over 98% of the replicative intermediates isolated following infection with wild-type virions at 33 degrees, 37 degrees or 40 degrees C or with tsA209 at 33 degrees C had initiated rep...


    pub_type: 杂志文章


    authors: Martin RG,Setlow VP

    更新日期:1980-06-01 00:00:00

  • SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.

    abstract::SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single posi...


    pub_type: 杂志文章


    authors: Marine JC,Topham DJ,McKay C,Wang D,Parganas E,Stravopodis D,Yoshimura A,Ihle JN

    更新日期:1999-09-03 00:00:00

  • Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.

    abstract::Cell-cell junctions respond to mechanical forces by changing their organization and function. To gain insight into the mechanochemical basis underlying junction mechanosensitivity, we analyzed tight junction (TJ) formation between the enveloping cell layer (EVL) and the yolk syncytial layer (YSL) in the gastrulating z...


    pub_type: 杂志文章


    authors: Schwayer C,Shamipour S,Pranjic-Ferscha K,Schauer A,Balda M,Tada M,Matter K,Heisenberg CP

    更新日期:2019-10-31 00:00:00

  • The secret life of ACE2 as a receptor for the SARS virus.

    abstract::The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...


    pub_type: 杂志文章


    authors: Dimitrov DS

    更新日期:2003-12-12 00:00:00

  • Interaction of positive and negative regulatory proteins in the galactose regulon of yeast.

    abstract::Transcriptional regulation in the galactose regulon of yeast is determined by an interplay between a positive regulatory protein, GAL4, and a negative regulatory protein, GAL80. We show that derivatives of GAL4 missing as few as 28 carboxy-terminal amino acids are not responsive to GAL80 regulation, implying that the ...


    pub_type: 杂志文章


    authors: Johnston SA,Salmeron JM Jr,Dincher SS

    更新日期:1987-07-03 00:00:00

  • Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.

    abstract::The mechanism by which cells decide to skip mitosis to become polyploid is largely undefined. Here we used a high-content image-based screen to identify small-molecule probes that induce polyploidization of megakaryocytic leukemia cells and serve as perturbagens to help understand this process. Our study implicates fi...


    pub_type: 杂志文章


    authors: Wen Q,Goldenson B,Silver SJ,Schenone M,Dancik V,Huang Z,Wang LZ,Lewis TA,An WF,Li X,Bray MA,Thiollier C,Diebold L,Gilles L,Vokes MS,Moore CB,Bliss-Moreau M,Verplank L,Tolliday NJ,Mishra R,Vemula S,Shi J,Wei L

    更新日期:2012-08-03 00:00:00

  • Concerted evolution of tRNA genes: intergenic conversion among three unlinked serine tRNA genes in S. pombe.

    abstract::In many cases the multiple genes coding for one specific tRNA are dispersed throughout the genome. The members of such a gene family nevertheless maintain a common nucleotide sequence during evolution. A major mechanism contributing to this concerted evolution is intergenic conversion. Here we show that it occurs betw...


    pub_type: 杂志文章


    authors: Amstutz H,Munz P,Heyer WD,Leupoid U,Kohli J

    更新日期:1985-04-01 00:00:00

  • The use of promoter fusions in Drosophila genetics: isolation of mutations affecting the heat shock response.

    abstract::We have constructed a gene fusion using the promoter of Drosophila hsp70 and the structural gene for Drosophila alcohol dehydrogenase (Adh) and used this construct to transform Adh-deficient flies. In these transformants, Adh is expressed only after heat shock. Like hsp70 itself, this heat-shock-inducible Adh (Adhhs) ...


    pub_type: 杂志文章


    authors: Bonner JJ,Parks C,Parker-Thornburg J,Mortin MA,Pelham HR

    更新日期:1984-07-01 00:00:00

  • Nucleotide sequence of salmon testes and salmon liver cytoplasmic initiator tRNA.

    abstract::Initiator tRNAs from the cytoplasm of salmon testes and salmon liver have been purified. The nucleotide sequence of these initiator tRNAs has been determined and found identical to that of initiator tRNA from mammalian cytoplasm. The only difference is the extent of modification of the nuceloside located between the d...


    pub_type: 杂志文章


    authors: Gillum AM,Urquhart N,Smith M,RajBhandary UL

    更新日期:1975-11-01 00:00:00

  • The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts.

    abstract::Receptor-mediated endocytosis of specific ligands is mediated through clustering of receptor-ligand complexes in coated pits on the cell surface. Following this clustering event, the ligand is internalized into a noncoated intracellular vesicle, the receptosome, which selectively avoids fusion with lysosomes and moves...


    pub_type: 杂志文章


    authors: Willingham MC,Pastan I

    更新日期:1980-08-01 00:00:00

  • Calmodulin-induced early-onset diabetes in transgenic mice.

    abstract::Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. We have produced three lines of transgenic mice carrying a calmodulin minigene regulated by the rat insulin II promoter. Immunohistochemistry and hybridization analyses in...


    pub_type: 杂志文章


    authors: Epstein PN,Overbeek PA,Means AR

    更新日期:1989-09-22 00:00:00

  • Isolation and transformation of primary mesenchymal cells of the chick embryo.

    abstract::Pure primary mesenchymal cells from definitive streak stage chick embryos have been prepared free of epiblast and hypoblast cells. These cells have the potential in culture to differentiate into erythroid cells, beating heart muscle tissue, chondrocytes and epithelial cells. Transformation in vitro of pure primary mes...


    pub_type: 杂志文章


    authors: Keane RW,Lindblad PC,Pierik LT,Ingram VM

    更新日期:1979-08-01 00:00:00

  • A cellular gene encodes scrapie PrP 27-30 protein.

    abstract::A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in...


    pub_type: 杂志文章


    authors: Oesch B,Westaway D,Wälchli M,McKinley MP,Kent SB,Aebersold R,Barry RA,Tempst P,Teplow DB,Hood LE

    更新日期:1985-04-01 00:00:00

  • Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels.

    abstract::Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...


    pub_type: 杂志文章


    authors: Clarke OB,Caputo AT,Hill AP,Vandenberg JI,Smith BJ,Gulbis JM

    更新日期:2010-06-11 00:00:00

  • Control of inducible gene expression by signal-dependent transcriptional elongation.

    abstract::Most inducible transcriptional programs consist of primary and secondary response genes (PRGs and SRGs) that differ in their kinetics of expression and in their requirements for new protein synthesis and chromatin remodeling. Here we show that many PRGs, in contrast to SRGs, have preassembled RNA polymerase II (Pol II...


    pub_type: 杂志文章


    authors: Hargreaves DC,Horng T,Medzhitov R

    更新日期:2009-07-10 00:00:00

  • At least 104 nucleotides are transposed from the 5' terminus of the avian sarcoma virus genome to the 5' termini of smaller viral mRNAs.

    abstract::Cells producing avian sarcoma virus (ASV) contain at least three virus-specific mRNAs, two of which are encoded within the 3' half of the viral genome. Each of these viral RNAs can hybridize with single-stranded DNA(cDNA5') that is complementary to a sequence of 101 nucleotides found at the 5' terminus of the ASV geno...


    pub_type: 杂志文章


    authors: Cordell B,Weiss SR,Varmus HE,Bishop JM

    更新日期:1978-09-01 00:00:00

  • Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.

    abstract::The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...


    pub_type: 杂志文章


    authors: Silver DL,Montell DJ

    更新日期:2001-12-28 00:00:00