Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components.

abstract：:Acquisition of the ability to produce and respond to a growth factor may result in increased cellular proliferation and could lead to malignant transformation. The fact that a large variety of tumor cells secrete transforming growth factor-alpha (TGF-alpha) suggests involvement of TGF-alpha in cellular transformation ...

journal_title：Cell

authors： Rosenthal A,Lindquist PB,Bringman TS,Goeddel DV,Derynck R

更新日期：1986-07-18 00:00:00

abstract：:Fos protein can trans-activate AP-1-dependent gene expression and trans-repress the c-fos promoter. Although we find that trans-repression is enhanced by coexpression of c-Jun, it does not require any of the AP-1 or ATF sites in the mouse c-fos promoter. A major target for repression is the serum response element (SRE...

journal_title：Cell

authors： Lucibello FC,Lowag C,Neuberg M,Müller R

更新日期：1989-12-22 00:00:00

abstract：:Lipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of signaling molecules with diverse physiological properties. This growth in knowledge is epitomized by lysophosphatidic acid (LPA), which functions through interactio...

journal_title：Cell

authors： Chrencik JE,Roth CB,Terakado M,Kurata H,Omi R,Kihara Y,Warshaviak D,Nakade S,Asmar-Rovira G,Mileni M,Mizuno H,Griffith MT,Rodgers C,Han GW,Velasquez J,Chun J,Stevens RC,Hanson MA

更新日期：2015-06-18 00:00:00

abstract：:We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks. Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors. Moreover, H2AX haploinsufficiency caused genomic instability in normal...

journal_title：Cell

authors： Bassing CH,Suh H,Ferguson DO,Chua KF,Manis J,Eckersdorff M,Gleason M,Bronson R,Lee C,Alt FW

更新日期：2003-08-08 00:00:00

abstract：:The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga maritima L10 in complex with three L7/12 N-terminal-domain dimers, refine the structure of an archaeal L10E N-terminal domain on the 50S subunit, and identify th...

journal_title：Cell

authors： Diaconu M,Kothe U,Schlünzen F,Fischer N,Harms JM,Tonevitsky AG,Stark H,Rodnina MV,Wahl MC

更新日期：2005-07-01 00:00:00

abstract：:Striated muscle-specific disruption of the dystroglycan (DAG1) gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a remarkably mild muscular dystrophy with hypertrophy and without tissue fibrosis. We find that satellite cells, expressing dystroglycan, support continued efficient r...

journal_title：Cell

authors： Cohn RD,Henry MD,Michele DE,Barresi R,Saito F,Moore SA,Flanagan JD,Skwarchuk MW,Robbins ME,Mendell JR,Williamson RA,Campbell KP

更新日期：2002-09-06 00:00:00

abstract：:Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemi...

journal_title：Cell

authors： Trimarchi T,Bilal E,Ntziachristos P,Fabbri G,Dalla-Favera R,Tsirigos A,Aifantis I

更新日期：2014-07-31 00:00:00

abstract：:In cells of the B-lymphocyte lineage, 8.4 kb transcripts are constitutively produced from unrearranged kappa constant region (kappa 0) loci. To help elucidate the molecular basis of this phenomenon, we have determined the nucleotide sequence surrounding the site of transcriptional initiation. The kappa 0 transcripts a...

journal_title：Cell

authors： Van Ness BG,Weigert M,Coleclough C,Mather EL,Kelley DE,Perry RP

更新日期：1981-12-01 00:00:00

abstract：:The thymus exports a selected subset of virgin T lymphocytes to the peripheral lymphoid organs. The mature phenotype of these thymus emigrants is similar to that of medullary thymocytes and has been cited as supporting a medullary rather than cortical exit site. Using the monoclonal antibody MEL-14, we identify a 1%-3...

journal_title：Cell

authors： Reichert RA,Gallatin WM,Butcher EC,Weissman IL

更新日期：1984-08-01 00:00:00

abstract：:T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4+ T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83-/-) mice had a specific block in CD4+ single-positive thymocyte development with...

journal_title：Cell

authors： Fujimoto Y,Tu L,Miller AS,Bock C,Fujimoto M,Doyle C,Steeber DA,Tedder TF

更新日期：2002-03-22 00:00:00

abstract：:Rosalind Franklin provided the key data for deriving the double helix structure of DNA. The English chemist also pioneered structural studies of colloids, viruses, and RNA. To celebrate the 100th anniversary of Franklin's birth, I summarize her work, which shaped the emerging discipline of molecular biology. ...

journal_title：Cell

authors： Cramer P

更新日期：2020-08-20 00:00:00

abstract：:There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by...

journal_title：Cell

authors： Fischbach MA

更新日期：2018-08-09 00:00:00

abstract：:CEM15/APOBEC3G is a cellular protein required for resistance to infection by virion infectivity factor (Vif)-deficient human immunodeficiency virus (HIV). Here, using a murine leukemia virus (MLV)-based system, we provide evidence that CEM15/APOBEC3G is a DNA deaminase that is incorporated into virions during viral pr...

journal_title：Cell

authors： Harris RS,Bishop KN,Sheehy AM,Craig HM,Petersen-Mahrt SK,Watt IN,Neuberger MS,Malim MH

更新日期：2003-06-13 00:00:00

abstract：:The v-erbB gene product of avian erythroblastosis virus (AEV) has extensive homology with the receptor for epidermal growth factor (EGF). We report here that chicken embryo fibroblasts (CEF) transformed by AEV show enhanced tyrosine phosphorylation of a number of cellular polypeptides, including the 36 kd protein, whi...

journal_title：Cell

authors： Gilmore T,DeClue JE,Martin GS

更新日期：1985-03-01 00:00:00

abstract：:Transposon Tn10 inserts at many sites in the bacterial chromosome, but preferentially inserts at particular hotspots. We believe we have identified the target DNA signal responsible for this specificity. We have determined the DNA sequences of 11 Tn10 insertion sites and identified a particular 6 base pair (bp) symmet...

journal_title：Cell

authors： Halling SM,Kleckner N

更新日期：1982-01-01 00:00:00

abstract：:Retroviral DNA integration involves a coordinated set of DNA cutting and joining reactions. We find that the IN protein of Moloney murine leukemia virus (MoMLV) is the only viral protein required to accomplish these reactions in vitro. IN protein has a site-specific nuclease activity that cleaves 2 nucleotides from th...

journal_title：Cell

authors： Craigie R,Fujiwara T,Bushman F

更新日期：1990-08-24 00:00:00

abstract：:Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immu...

journal_title：Cell

authors： Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Sch

更新日期：2018-01-11 00:00:00

abstract：:The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence het...

journal_title：Cell

authors： Astell CR,Smith M,Chow MB,Ward DC

更新日期：1979-07-01 00:00:00

abstract：:In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of...

journal_title：Cell

authors： Friedberg EC,Fischhaber PL

更新日期：2003-04-18 00:00:00

abstract：:Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the N...

journal_title：Cell

authors： Soleimanpour SA,Gupta A,Bakay M,Ferrari AM,Groff DN,Fadista J,Spruce LA,Kushner JA,Groop L,Seeholzer SH,Kaufman BA,Hakonarson H,Stoffers DA

更新日期：2014-06-19 00:00:00

abstract：:gamma-Irradiation of human diploid fibroblasts in the G1 interval caused arrest of the cell cycle prior to S phase. This cell cycle block was correlated with a lack of activation of both cyclin E-Cyclin-dependent kinase 2 (Cdk2) and cyclin A-Cdk2 kinases and depended on wild-type p53. Although the accumulation of cycl...

journal_title：Cell

authors： Dulić V,Kaufmann WK,Wilson SJ,Tlsty TD,Lees E,Harper JW,Elledge SJ,Reed SI

更新日期：1994-03-25 00:00:00

abstract：:An examination of Abelson murine leukemia virus (A-MuL V)-hematopoietic cell interaction in cultures of fetal tissues reveals that A-MuLV can stimulate the formation of two different types of colonies. One type of colony is white and composed of A-MuLV-transformed lymphoid cells that can develop into established cell ...

journal_title：Cell

authors： Waneck GL,Rosenberg N

更新日期：1981-10-01 00:00:00

abstract：:Significant advances have been made in developing novel therapeutics for cancer treatment, and targeted therapies have revolutionized the treatment of some cancers. Despite the promise, only about five percent of new cancer drugs are approved, and most fail due to lack of efficacy. The indication is that current precl...

journal_title：Cell

authors： Day CP,Merlino G,Van Dyke T

更新日期：2015-09-24 00:00:00

abstract：:Protein-DNA binding is mediated by the recognition of the chemical signatures of the DNA bases and the 3D shape of the DNA molecule. Because DNA shape is a consequence of sequence, it is difficult to dissociate these modes of recognition. Here, we tease them apart in the context of Hox-DNA binding by mutating residues...

journal_title：Cell

authors： Abe N,Dror I,Yang L,Slattery M,Zhou T,Bussemaker HJ,Rohs R,Mann RS

更新日期：2015-04-09 00:00:00

abstract：:Misfolded proteins accumulating in several neurodegenerative diseases (including Alzheimer, Parkinson, and Huntington diseases) can cause aggregation of their native counterparts through a mechanism similar to the infectious prion protein's induction of a pathogenic conformation onto its cellular isoform. Evidence for...

journal_title：Cell

authors： Polymenidou M,Cleveland DW

更新日期：2011-10-28 00:00:00

abstract：:Characteristic of chronic myelogenous leukemia (CML) is the presence of the chimeric p210(bcr-abl) protein possessing elevated protein tyrosine kinase activity relative to normal c-abl tyrosine kinase. Hematopoietic progenitors isolated from CML patients in the chronic phase contain a constitutively tyrosine-phosphory...

journal_title：Cell

authors： Carpino N,Wisniewski D,Strife A,Marshak D,Kobayashi R,Stillman B,Clarkson B

更新日期：1997-01-24 00:00:00

abstract：:Trypanosoma brucei variant surface glycoprotein (VSG) genes are activated either by duplicative (DA) transposition of the gene to a pre-activated expression site or by nonduplicative (NDA) activation of a previously silent telomeric gene. We have obtained a recombinant clone spanning the 5' barren region of the expres...

journal_title：Cell

authors： Cully DF,Ip HS,Cross GA

更新日期：1985-08-01 00:00:00

abstract：:The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds...

journal_title：Cell

authors： Hopfner KP

更新日期：2009-10-02 00:00:00

abstract：:CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in vivo as well as ex vivo genome editing using adeno-associated virus (AAV)-, lentivirus-, or parti...

journal_title：Cell

authors： Platt RJ,Chen S,Zhou Y,Yim MJ,Swiech L,Kempton HR,Dahlman JE,Parnas O,Eisenhaure TM,Jovanovic M,Graham DB,Jhunjhunwala S,Heidenreich M,Xavier RJ,Langer R,Anderson DG,Hacohen N,Regev A,Feng G,Sharp PA,Zhang F

更新日期：2014-10-09 00:00:00

abstract：:Vaccinia virus recombinants were generated which express the intact gp70/p15E of Friend mink cell focus inducing virus (F-MCFV) or truncated forms of the glycoprotein that lack the transmembrane and cytoplasmic domains. The transport of the intact and truncated envelope glycoproteins to apical or basolateral surfaces ...

journal_title：Cell

authors： Stephens EB,Compans RW

更新日期：1986-12-26 00:00:00