Abstract：
:Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemia (T-ALL). By integrating transcriptome profiles with chromatin state maps, we have uncovered many previously unreported T-ALL-specific lncRNA genes, a fraction of which are directly controlled by the Notch1/Rpbjκ activator complex. Finally we have shown that one specific Notch-regulated lncRNA, LUNAR1, is required for efficient T-ALL growth in vitro and in vivo due to its ability to enhance IGF1R mRNA expression and sustain IGF1 signaling. These results confirm that lncRNAs are important downstream targets of the Notch signaling pathway, and additionally they are key regulators of the oncogenic state in T-ALL.
journal_name
Celljournal_title
Cellauthors
Trimarchi T,Bilal E,Ntziachristos P,Fabbri G,Dalla-Favera R,Tsirigos A,Aifantis Idoi
10.1016/j.cell.2014.05.049subject
Has Abstractpub_date
2014-07-31 00:00:00pages
593-606issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(14)00809-5journal_volume
158pub_type
杂志文章相关文献
CELL文献大全abstract：:The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinates and hence stabilizes the tumor suppressor protein p53. Here, we report the crystal structures of the 40 kDa catalytic cor...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)01199-6
更新日期：2002-12-27 00:00:00
abstract：:The actin-filled stereocilia of cochlear hair cells deflect in response to sound by pivoting around rootlets at their insertion points at the sensory cell surface. Kitajiri et al. (2010) now show that the actin-binding protein TRIOBP tightly bundles the actin filaments into rootlets, endowing these stereocilia "pivots...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.05.022
更新日期：2010-05-28 00:00:00
abstract：:The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus (A-MuLV) synthesize a mu chain but no detectable light chain. Aside from this mu-only phenotype, lines that make only light chain, both chains or no immunoglobulin-related polypeptides have also been found. T...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90014-x
更新日期：1979-02-01 00:00:00
abstract：:Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding was observed from the upper respiratory tract of a female immunocompromised individual with chronic lymphocytic leukemia and acquired hypogammaglobulinemia. Shedding of infectious SARS-CoV-2 was observed up to 70 days, and of genomic and s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.10.049
更新日期：2020-12-23 00:00:00
abstract：:In extracts from rat and calf uterus, the steroid hormone 17 beta-estradiol stimulates the binding of its specific receptor protein to DNA. This interaction appears to be of low affinity (half of the estradiol-activated, 5S receptor bound at 300-400 mug/ml DNA) and nonspecific with respect to DNA base sequence. No bin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90150-6
更新日期：1975-04-01 00:00:00
abstract：:p25rum1 from the fission yeast S. pombe is shown to act as a specific in vitro inhibitor of the p34cdc2/p56cdc13 mitotic kinase. It is also shown that early G1 cells contain p25rum1, which associates with and inhibits the mitotic kinase, and maintains p56cdc13 mitotic B cyclin at a low level, ensuring that these cells...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90215-5
更新日期：1995-12-15 00:00:00
abstract：:We describe a new repressible binary expression system based on the regulatory genes from the Neurospora qa gene cluster. This "Q system" offers attractive features for transgene expression in Drosophila and mammalian cells: low basal expression in the absence of the transcriptional activator QF, high QF-induced expre...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.02.025
更新日期：2010-04-30 00:00:00
abstract：:In this report, we describe the isolation, sequence, and initial characterization of the cDNA for the muscle-specific regulatory factor skeletal myogenin. Transfection of myogenin into the mesenchymal cell line C3H10T1/2 produces cells expressing muscle-specific markers. Myogenin is absent in undifferentiated cells, p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90583-7
更新日期：1989-02-24 00:00:00
abstract：:We describe here a bizarre organization of the single large subunit (LSU) and small subunit (SSU) rRNA genes in the mitochondrial DNA of Chlamydomonas reinhardtii. Each gene is discontinuous, with gene pieces encoding specific rRNA domains ("modules") interspersed with one another and with intact protein coding and tR...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90026-8
更新日期：1988-11-04 00:00:00
abstract：:The redox-regulated chaperone Hsp33 protects organisms against oxidative stress that leads to protein unfolding. Activation of Hsp33 is triggered by the oxidative unfolding of its own redox-sensor domain, making Hsp33 a member of a recently discovered class of chaperones that require partial unfolding for full chapero...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.01.045
更新日期：2012-03-02 00:00:00
abstract：:ATP increases microtubule steady state assembly and disassembly rates in vitro in a concentration-dependent manner. Bovine brain microtubules, composed of 75% tubulin and 25% high molecular weight microtubule-associated proteins (MAPs), were purified by three cycles of assembly and disassembly in the absence of ATP. W...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90122-3
更新日期：1979-11-01 00:00:00
abstract：:The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear. We find that Stk25, a modifier of Reelin-Dab1 signaling, regulates Golgi morphology and neuronal polarization as part of an LKB1-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.10.029
更新日期：2010-11-24 00:00:00
abstract：:MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-containing exosomes (Exos), which cause glucose intolerance and insulin resistance when administered to lean mice. Conversely, ATM Exos obtained f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.08.035
更新日期：2017-10-05 00:00:00
abstract：:The E. coli replication fork synthesizes DNA at the rate of nearly 1000 nt/s. We show here that an interaction between the tau subunit of the replicative polymerase (the DNA polymerase III holoenzyme) and the replication fork DNA helicase (DnaB) is required to mediate this high rate of replication fork movement. In th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81039-9
更新日期：1996-02-23 00:00:00
abstract：:X-linked lissencephaly and "double cortex" are allelic human disorders mapping to Xq22.3-Xq23 associated with arrest of migrating cerebral cortical neurons. We identified a novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Dou...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80899-5
更新日期：1998-01-09 00:00:00
abstract：:Periodic transcription of yeast histone genes has been demonstrated by DNA excess filter hybridization of in vivo pulse-labeled RNA isolated from synchronous cell cultures. Using strains carrying cell division cycle (cdc) mutations, we show that both activation and termination of transcription are determined by tempor...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90036-8
更新日期：1982-08-01 00:00:00
abstract：:Mitochondrial respiratory-chain complexes assemble from subunits of dual genetic origin assisted by specialized assembly factors. Whereas core subunits are translated on mitochondrial ribosomes, others are imported after cytosolic translation. How imported subunits are ushered to assembly intermediates containing mito...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.11.053
更新日期：2012-12-21 00:00:00
abstract：:Nuclear pore complexes (NPCs) mediate transport across the nuclear envelope. In yeast, they also interact with active genes, attracting or retaining them at the nuclear periphery. In higher eukaryotes, some NPC components (nucleoporins) are also found in the nucleoplasm, with a so far unknown function. We have functio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.01.011
更新日期：2010-02-05 00:00:00
abstract：:In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2010.05.033
更新日期：2010-06-11 00:00:00
abstract：:Spindle assembly requires the coordinated action of multiple cellular structures to nucleate and organize microtubules in a precise spatiotemporal manner. Among them, the contributions of centrosomes, chromosomes, and microtubules have been well studied, yet the involvement of membrane-bound organelles remains largely...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.06.014
更新日期：2015-07-16 00:00:00
abstract：:The structure and organization on the Escherichia coli chromosome of the gene cluster coding for two methionine tRNAs (tRNAmMet), four glutamine tRNAs (two tRNA1Gln and two tRNA2Gln), and a previously unidentified tRNA (called tRNAx) have been studied by restriction enzyme analysis and DNA sequencing, utilizing a spec...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90288-9
更新日期：1981-01-01 00:00:00
abstract：:The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem cell niche, to esta...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(04)00255-7
更新日期：2004-03-19 00:00:00
abstract：:Repression of the yeast silent mating type loci requires cis-acting sequences located over 1 kb from the regulated promoters. One of these sites, a "silencer," exhibits enhancer-like distance- and orientation-independence. The silencer demonstrates both autonomous replication sequence (ARS) activity and a centromere-l...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90094-8
更新日期：1987-12-04 00:00:00
abstract：:In contrast to uninfected chicken embryo fibroblasts (CEFs), CEFs infected with a retroviral vector that carries the v-erbA gene of avian erythroblastosis virus displayed new properties. These included limited anchorage-independent growth in soft agar, growth without latency in serum-supplemented medium, ability to ov...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90545-9
更新日期：1987-06-05 00:00:00
abstract：:In April this year, a new influenza virus of swine origin emerged in Mexico and spread rapidly around the world. As the Northern hemisphere winter flu season kicks off, Laura Vargas-Parada reports on the measures that Mexico is taking to combat the H1N1 pandemic. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.12.019
更新日期：2009-12-24 00:00:00
abstract：:A model of hematopoietic development wherein multipotentiality is conserved until segregation of myeloid and lymphoid potential has recently been challenged, proposing that megakaryocyte/erythrocyte (MegE) potential is lost in Flk2/Flt3-expressing early progenitors. Here, we used sensitive in vivo approaches to quanti...
journal_title：Cell
pub_type： 信件
doi：10.1016/j.cell.2006.06.037
更新日期：2006-07-28 00:00:00
abstract：:G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes by multidimensional protein interaction technology (MudPIT). Whi5 was identified as a stably bound component of SBF but not MBF. Inactiv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.05.025
更新日期：2004-06-25 00:00:00
abstract：:DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks conver...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.08.030
更新日期：2008-09-19 00:00:00
abstract：:Rhythmic cardiac contractions depend on the organized propagation of depolarizing and repolarizing wavefronts. Repolarization is spatially heterogeneous and depends largely on gradients of potassium currents. Gradient disruption in heart disease may underlie susceptibility to fatal arrhythmias, but it is not known how...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.08.004
更新日期：2005-10-21 00:00:00
abstract：:The mechanisms by which molecular chaperones assist quality control of cytosolic proteins are poorly understood. Analysis of the chaperone requirements for degradation of misfolded variants of a cytosolic protein, the VHL tumor suppressor, reveals that distinct chaperone pathways mediate its folding and quality contro...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.03.024
更新日期：2005-06-03 00:00:00
