Abstract:
:p25rum1 from the fission yeast S. pombe is shown to act as a specific in vitro inhibitor of the p34cdc2/p56cdc13 mitotic kinase. It is also shown that early G1 cells contain p25rum1, which associates with and inhibits the mitotic kinase, and maintains p56cdc13 mitotic B cyclin at a low level, ensuring that these cells do not undergo a premature lethal entry into mitosis. A high level of p25rum1 in G2 cells inhibits the p34cdc2/p56cdc13 kinase that removes the block preventing a further S phase and leads to repeated rounds of DNA replication. Thus, the cyclin-dependent kinase inhibitor p25rum1, acting on the p34cdc2 mitotic kinase, plays an important role in ensuring the correct sequence of S phase and mitosis during the cell cycle.
journal_name
Celljournal_title
Cellauthors
Correa-Bordes J,Nurse Pdoi
10.1016/0092-8674(95)90215-5subject
Has Abstractpub_date
1995-12-15 00:00:00pages
1001-9issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(95)90215-5journal_volume
83pub_type
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