Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.

abstract：:Seeing begins in the photoreceptors, where light is absorbed and signaled to the nervous system. Throughout the animal kingdom, photoreceptors are diverse in design and purpose. Nonetheless, phototransduction-the mechanism by which absorbed photons are converted into an electrical response-is highly conserved and base...

journal_title：Cell

authors： Yau KW,Hardie RC

更新日期：2009-10-16 00:00:00

abstract：:A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light ...

journal_title：Cell

authors： Stanewsky R,Kaneko M,Emery P,Beretta B,Wager-Smith K,Kay SA,Rosbash M,Hall JC

更新日期：1998-11-25 00:00:00

abstract：:The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic details underlying these processes remain to be determined. In this study, we demonstrate endothelial disrupti...

journal_title：Cell

authors： Aid M,Busman-Sahay K,Vidal SJ,Maliga Z,Bondoc S,Starke C,Terry M,Jacobson CA,Wrijil L,Ducat S,Brook OR,Miller AD,Porto M,Pellegrini KL,Pino M,Hoang TN,Chandrashekar A,Patel S,Stephenson K,Bosinger SE,Andersen H,

更新日期：2020-11-25 00:00:00

abstract：:We are studying mice that carry a targeted disruption of the gene encoding insulin-like growth factor II (IGF-II). Transmission of this mutation through the male germline results in heterozygous progeny that are growth deficient. In contrast, when the disrupted gene is transmitted maternally, the heterozygous offsprin...

journal_title：Cell

authors： DeChiara TM,Robertson EJ,Efstratiadis A

更新日期：1991-02-22 00:00:00

abstract：:Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...

journal_title：Cell

authors： González-Gaitán M,Jäckle H

更新日期：1997-03-21 00:00:00

abstract：:Secretion of cytolytic granules content at the immunological synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Defective...

journal_title：Cell

authors： Feldmann J,Callebaut I,Raposo G,Certain S,Bacq D,Dumont C,Lambert N,Ouachée-Chardin M,Chedeville G,Tamary H,Minard-Colin V,Vilmer E,Blanche S,Le Deist F,Fischer A,de Saint Basile G

更新日期：2003-11-14 00:00:00

abstract：:We describe a new repressible binary expression system based on the regulatory genes from the Neurospora qa gene cluster. This "Q system" offers attractive features for transgene expression in Drosophila and mammalian cells: low basal expression in the absence of the transcriptional activator QF, high QF-induced expre...

journal_title：Cell

authors： Potter CJ,Tasic B,Russler EV,Liang L,Luo L

更新日期：2010-04-30 00:00:00

abstract：:Pseudotypes of vesicular stomatitis virus (VSV) and Moloney murine leukemia virus (MuLV), defined by their resistance to neutralization by anti-VSV antiserum, are released preferentially at early times after infection of MuLV-producing cells with VSV. At later times, after synthesis of MuLV proteins has been inhibited...

journal_title：Cell

authors： Witte ON,Baltimore D

更新日期：1977-07-01 00:00:00

abstract：:The S. pombe nuc2+ gene is required for mitotic chromosome disjunction. Its mutation arrests mitosis at the metaphase. The gene product is present in the nuclear scaffold-like fraction. The nuc2+ protein contains a domain, separated from ten 34 amino acid repeat segments, that is capable of binding AT-rich DNA in vitr...

journal_title：Cell

authors： Hirano T,Kinoshita N,Morikawa K,Yanagida M

更新日期：1990-01-26 00:00:00

abstract：:Nine transcripts complementary to mouse L cell mitochondrial DNA have been detected, sized and mapped to restriction fragments using the method of Berk and Sharp (1977). RNA isolated from L cell mitochondria was hybridized to 32P-labeled, cloned L cell mitochondrial DNA restriction fragments in 70% formamide under con...

journal_title：Cell

authors： Battey J,Clayton DA

更新日期：1978-05-01 00:00:00

abstract：:Adult neovascularization relies on the recruitment of circulating cells, but their angiogenic roles and recruitment mechanisms are unclear. We show that the endothelial growth factor VEGF is sufficient for organ homing of circulating mononuclear myeloid cells and is required for their perivascular positioning and rete...

journal_title：Cell

authors： Grunewald M,Avraham I,Dor Y,Bachar-Lustig E,Itin A,Jung S,Chimenti S,Landsman L,Abramovitch R,Keshet E

更新日期：2006-01-13 00:00:00

abstract：:The susceptibility to repair of particular base mismatches by the hex system of Streptococcus pneumoniae was examined by comparison of the nucleotide sequence of the wild-type and eight mutant alleles of the malM gene. A detailed restriction map was constructed for pLS70, and the nucleotide sequence was determined for...

journal_title：Cell

authors： Lacks SA,Dunn JJ,Greenberg B

更新日期：1982-12-01 00:00:00

abstract：:Malignancy can be suppressed by the immune system in a process termed immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous cancers and the composition of participating cell types remains obscure. Here, we show that cell transformation triggers a tissue-resident lymphocyte response in on...

journal_title：Cell

authors： Dadi S,Chhangawala S,Whitlock BM,Franklin RA,Luo CT,Oh SA,Toure A,Pritykin Y,Huse M,Leslie CS,Li MO

更新日期：2016-01-28 00:00:00

abstract：:Conditions are described for programming with active transcription complexes essentially all the Xenopus 5S RNA genes added to an extract of Xenopus oocyte nuclei. We call this rate enhancement. Transcription by SP6 RNA polymerase of either strand of a Xenopus 5S RNA gene is unimpeded by the presence of a complete tra...

journal_title：Cell

authors： Wolffe AP,Jordan E,Brown DD

更新日期：1986-02-14 00:00:00

abstract：:Mice homozygous for a targeted mutation of the Hoxa-2 (Hox 1.11) gene are born with cleft palates and die within 24 hr of birth. Analysis of stained skeletons revealed that homozygous mutant animals contained multiple cranial skeletal defects, including a duplication of the ossification centers of the bones of the mid...

journal_title：Cell

authors： Gendron-Maguire M,Mallo M,Zhang M,Gridley T

更新日期：1993-12-31 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and va...

journal_title：Cell

authors： Oberfeld B,Achanta A,Carpenter K,Chen P,Gilette NM,Langat P,Said JT,Schiff AE,Zhou AS,Barczak AK,Pillai S

更新日期：2020-05-14 00:00:00

abstract：:The molecular nature of mutations arising in dysgenic hybrids between P and M Drosophila melanogaster strains has been investigated. Seven independent mutations at the white locus were examined, and these fell into two classes on the basis of their genetic and structural properties. The five mutations comprising the f...

journal_title：Cell

authors： Rubin GM,Kidwell MG,Bingham PM

更新日期：1982-07-01 00:00:00

abstract：:The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteocl...

journal_title：Cell

authors： Lacey DL,Timms E,Tan HL,Kelley MJ,Dunstan CR,Burgess T,Elliott R,Colombero A,Elliott G,Scully S,Hsu H,Sullivan J,Hawkins N,Davy E,Capparelli C,Eli A,Qian YX,Kaufman S,Sarosi I,Shalhoub V,Senaldi G,Guo J,Delane

更新日期：1998-04-17 00:00:00

abstract：:The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression t...

journal_title：Cell

authors： Mellor J

更新日期：2006-07-14 00:00:00

abstract：:Even a simple sensory stimulus can elicit distinct innate behaviors and sequences. During sensorimotor decisions, competitive interactions among neurons that promote distinct behaviors must ensure the selection and maintenance of one behavior, while suppressing others. The circuit implementation of these competitive i...

journal_title：Cell

authors： Jovanic T,Schneider-Mizell CM,Shao M,Masson JB,Denisov G,Fetter RD,Mensh BD,Truman JW,Cardona A,Zlatic M

更新日期：2016-10-20 00:00:00

abstract：:The adult male accessory glands of D. melanogaster synthesize and secrete a peptide that represses female sexual receptivity and stimulates oviposition. Normally, this peptide is transferred to females during copulation; however, the peptide shows the same biological activity after purification and subsequent injectio...

journal_title：Cell

authors： Chen PS,Stumm-Zollinger E,Aigaki T,Balmer J,Bienz M,Böhlen P

更新日期：1988-07-29 00:00:00

abstract：:Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immu...

journal_title：Cell

authors： Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Sch

更新日期：2018-01-11 00:00:00

abstract：:How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulat...

journal_title：Cell

authors： Gobert M,Lafaille JJ

更新日期：2012-07-06 00:00:00

abstract：:Despite the obvious importance of epithelial stem cells in tissue homeostasis and tumorigenesis, little is known about their specific location or biological characteristics. Using 3H-thymidine labeling, we have identified a subpopulation of corneal epithelial basal cells, located in the peripheral cornea in a region c...

journal_title：Cell

authors： Cotsarelis G,Cheng SZ,Dong G,Sun TT,Lavker RM

更新日期：1989-04-21 00:00:00

abstract：:The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neu...

journal_title：Cell

authors： Zhao H,Reed RR

更新日期：2001-03-09 00:00:00

abstract：:Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been elucidated. Here, we discovered an unexpected role of the Hippo pathway in suppressing anti-tumor immunity. We demonstrate that, in three...

journal_title：Cell

authors： Moroishi T,Hayashi T,Pan WW,Fujita Y,Holt MV,Qin J,Carson DA,Guan KL

更新日期：2016-12-01 00:00:00

abstract：:A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...

journal_title：Cell

authors： Davies AA,Neiss A,Ulrich HD

更新日期：2010-06-11 00:00:00

abstract：:Chromosome segregation at meiosis I depends on pairing and crossing-over between homologs. In most eukaryotes, pairing culminates with formation of the proteinaceous synaptonemal complex (SC). In budding yeast, recombination initiates through double-strand DNA breaks (DSBs) and is thought to be essential for SC format...

journal_title：Cell

authors： Dernburg AF,McDonald K,Moulder G,Barstead R,Dresser M,Villeneuve AM

更新日期：1998-08-07 00:00:00

abstract：:Most bacteria that colonize eukaryotes must bind directly to host cells to establish a replicative niche. In enteric bacteria, adhesion to host cells is often promoted by a lectin found on surface-localized pili. Some pili promote efficient adhesion only when they are subjected to shear stress, as found during the flo...

journal_title：Cell

authors： Isberg RR,Barnes P

更新日期：2002-07-12 00:00:00

abstract：:D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse development and in proliferation by generating mice lacking all D-cyclins. We found that these cyclin D1(-/-)D2(-/-)D3(-/-) mice develop u...

journal_title：Cell

authors： Kozar K,Ciemerych MA,Rebel VI,Shigematsu H,Zagozdzon A,Sicinska E,Geng Y,Yu Q,Bhattacharya S,Bronson RT,Akashi K,Sicinski P

更新日期：2004-08-20 00:00:00