Abstract:
:The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes that typify osteoclast development. OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development.
journal_name
Celljournal_title
Cellauthors
Lacey DL,Timms E,Tan HL,Kelley MJ,Dunstan CR,Burgess T,Elliott R,Colombero A,Elliott G,Scully S,Hsu H,Sullivan J,Hawkins N,Davy E,Capparelli C,Eli A,Qian YX,Kaufman S,Sarosi I,Shalhoub V,Senaldi G,Guo J,Delanedoi
10.1016/s0092-8674(00)81569-xsubject
Has Abstractpub_date
1998-04-17 00:00:00pages
165-76issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81569-Xjournal_volume
93pub_type
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