Abstract:
:Cell lines from rhabdomyosarcomas, which are tumors of muscle origin, have been used as models of CD4-independent HIV infection. These cell lines can be induced to differentiate in vitro. We report here that the vpr gene of HIV1 is sufficient for the differentiation of the human rhabdomyosarcoma cell line TE671. Differentiated cells are characterized by great enlargement, altered morphology, lack of replication, and high level expression of the muscle-specific protein myosin. We have also observed the morphological differentiation and inhibition of proliferation of two other transformed cell lines. vpr-transfected cells remain fully viable in culture for extended periods. These observations elucidate a potential role for vpr in the virus life cycle and raise the possibility that some aspects of HIV-induced pathologies may be caused by a disturbance of cells by vpr.
journal_name
Celljournal_title
Cellauthors
Levy DN,Fernandes LS,Williams WV,Weiner DBdoi
10.1016/0092-8674(93)90073-ysubject
Has Abstractpub_date
1993-02-26 00:00:00pages
541-50issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(93)90073-Yjournal_volume
72pub_type
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