Fruit fly family fun.

abstract：:PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate. Recently, nuclear compartmentalization of PTEN was found as a key component of its tumor-suppressive activity; however its nuclear function remains poorly defined. Here...

journal_title：Cell

authors： Song MS,Carracedo A,Salmena L,Song SJ,Egia A,Malumbres M,Pandolfi PP

更新日期：2011-01-21 00:00:00

abstract：:Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...

journal_title：Cell

authors： Iwase S,Lan F,Bayliss P,de la Torre-Ubieta L,Huarte M,Qi HH,Whetstine JR,Bonni A,Roberts TM,Shi Y

更新日期：2007-03-23 00:00:00

abstract：:We present a strategy for generating and analyzing comprehensive genetic-interaction maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of aggravating or alleviating interactions between gene pairs. Crucial to the interpretation of E-MAPs is their high-density nature made possible by ...

journal_title：Cell

authors： Schuldiner M,Collins SR,Thompson NJ,Denic V,Bhamidipati A,Punna T,Ihmels J,Andrews B,Boone C,Greenblatt JF,Weissman JS,Krogan NJ

更新日期：2005-11-04 00:00:00

abstract：:The trk tyrosine kinase proto-oncogene product gp140prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high affinity NGF binding an...

journal_title：Cell

authors： Loeb DM,Maragos J,Martin-Zanca D,Chao MV,Parada LF,Greene LA

更新日期：1991-09-06 00:00:00

abstract：:Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a ...

journal_title：Cell

authors： Aguzzi A,Polymenidou M

更新日期：2004-01-23 00:00:00

abstract：:Acquisition of the ability to produce and respond to a growth factor may result in increased cellular proliferation and could lead to malignant transformation. The fact that a large variety of tumor cells secrete transforming growth factor-alpha (TGF-alpha) suggests involvement of TGF-alpha in cellular transformation ...

journal_title：Cell

authors： Rosenthal A,Lindquist PB,Bringman TS,Goeddel DV,Derynck R

更新日期：1986-07-18 00:00:00

abstract：:The ClyA protein is a pore-forming cytotoxin expressed by Escherichia coli and some other enterobacteria. It confers cytotoxic activity toward mammalian cells, but it has remained unknown how ClyA is surface exposed and exported from bacterial cells. Outer-membrane vesicles (OMVs) released from the bacteria were shown...

journal_title：Cell

authors： Wai SN,Lindmark B,Söderblom T,Takade A,Westermark M,Oscarsson J,Jass J,Richter-Dahlfors A,Mizunoe Y,Uhlin BE

更新日期：2003-10-03 00:00:00

abstract：:The yeast plasmid 2 micron circle actively maintains high but stable copy levels in the cell, even though the plasmid confers no selective advantage to its host. To address the mechanism by which stable copy control is achieved, we have examined the level of expression of the genes resident on the yeast plasmid 2 micr...

journal_title：Cell

authors： Som T,Armstrong KA,Volkert FC,Broach JR

更新日期：1988-01-15 00:00:00

abstract：:SR proteins constitute a family of pre-mRNA splicing factors that play important roles in both constitutive and regulated splicing. Here, we describe one member of the family, which we call SRp38, with unexpected properties. Unlike other SR proteins, SRp38 cannot activate splicing and is essentially inactive in splici...

journal_title：Cell

authors： Shin C,Manley JL

更新日期：2002-11-01 00:00:00

abstract：:DNA transposition has contributed significantly to evolution of eukaryotes and prokaryotes. Insertion sequences (ISs) are the simplest prokaryotic transposons and are divided into families on the basis of their organization and transposition mechanism. Here, we describe a link between transposition of IS608 and ISDra2...

journal_title：Cell

authors： Ton-Hoang B,Pasternak C,Siguier P,Guynet C,Hickman AB,Dyda F,Sommer S,Chandler M

更新日期：2010-08-06 00:00:00

abstract：:Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomo...

journal_title：Cell

authors： Chang WT,Newell PC,Gross JD

更新日期：1996-11-01 00:00:00

abstract：:We analyzed a family of proteins from hepatoma cell nuclei that bind to interleukin-6 responsive elements (IL-6REs) of several acute-phase genes. This family is characterized by leucine zipper domains compatible with that of the CCAAT/enhancer binding protein (C/EBP). A cDNA clone coding for a member of the family, IL...

journal_title：Cell

authors： Poli V,Mancini FP,Cortese R

更新日期：1990-11-02 00:00:00

abstract：:Determining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from over 12,000 genes across 32 normal human tissues. Tissue-specific or tissue...

journal_title：Cell

authors： Jiang L,Wang M,Lin S,Jian R,Li X,Chan J,Dong G,Fang H,Robinson AE,GTEx Consortium.,Snyder MP

更新日期：2020-10-01 00:00:00

abstract：:Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homolog of the HD gene. Homozygotes...

journal_title：Cell

authors： Nasir J,Floresco SB,O'Kusky JR,Diewert VM,Richman JM,Zeisler J,Borowski A,Marth JD,Phillips AG,Hayden MR

更新日期：1995-06-02 00:00:00

abstract：:Molecular chaperones assist protein folding by facilitating their "forward" folding and preventing aggregation. However, once aggregates have formed, these chaperones cannot facilitate protein disaggregation. Bacterial ClpB and its eukaryotic homolog Hsp104 are essential proteins of the heat-shock response, which have...

journal_title：Cell

authors： Lee S,Sowa ME,Watanabe YH,Sigler PB,Chiu W,Yoshida M,Tsai FT

更新日期：2003-10-17 00:00:00

abstract：:Prions, self-propagating protein structures that can be transmitted between cells and different organisms, usually consist of ordered protein aggregates. Alberti et al. (2009) now present a systematic approach for the discovery of new prions that expands the spectrum of their biological functions. ...

journal_title：Cell

authors： Fowler DM,Kelly JW

更新日期：2009-04-03 00:00:00

abstract：:The oligosaccharide-lipid which is the precursor of asparagine-linked oligosaccharides of eucaryotic glycoproteins is synthesized from sugar nucleotides in the endoplasmic reticulum. The transmembrane location of the assembly of this oligosaccharide-lipid has been studied in vitro in rat liver microsomes. Protease tre...

journal_title：Cell

authors： Snider MD,Sultzman LA,Robbins PW

更新日期：1980-09-01 00:00:00

abstract：:We have previously cloned lethal(2)giant larvae, a tumor-suppressor gene of Drosophila that normally controls cell proliferation and/or differentiation in the optic centers of the brain and the imaginal discs. Here we describe the structure of the l(2)gl genes as determined by sequencing genomic and cDNA clones. The s...

journal_title：Cell

authors： Jacob L,Opper M,Metzroth B,Phannavong B,Mechler BM

更新日期：1987-07-17 00:00:00

abstract：:Rubisco, the key enzyme of CO2 fixation in photosynthesis, is prone to inactivation by inhibitory sugar phosphates. Inhibited Rubisco undergoes conformational repair by the hexameric AAA+ chaperone Rubisco activase (Rca) in a process that is not well understood. Here, we performed a structural and mechanistic analysis...

journal_title：Cell

authors： Flecken M,Wang H,Popilka L,Hartl FU,Bracher A,Hayer-Hartl M

更新日期：2020-10-15 00:00:00

abstract：:While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we i...

journal_title：Cell

authors： Quigley DA,Dang HX,Zhao SG,Lloyd P,Aggarwal R,Alumkal JJ,Foye A,Kothari V,Perry MD,Bailey AM,Playdle D,Barnard TJ,Zhang L,Zhang J,Youngren JF,Cieslik MP,Parolia A,Beer TM,Thomas G,Chi KN,Gleave M,Lack NA,Zoube

更新日期：2018-07-26 00:00:00

abstract：:The role of S. cerevisiae YDJ1 protein (YDJ1p) in polypeptide translocation across membranes has been examined. A conditional ydj1 mutant strain (ydj1-151TS) is defective for import of several polypeptides into mitochondria and alpha factor into the endoplasmic reticulum at 37 degrees C. These defects are suppressed b...

journal_title：Cell

authors： Caplan AJ,Cyr DM,Douglas MG

更新日期：1992-12-24 00:00:00

abstract：:Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes...

journal_title：Cell

authors： Barker D,Schafer M,White R

更新日期：1984-01-01 00:00:00

abstract：:Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photo...

journal_title：Cell

authors： Deng XW,Matsui M,Wei N,Wagner D,Chu AM,Feldmann KA,Quail PH

更新日期：1992-11-27 00:00:00

abstract：:The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now pres...

journal_title：Cell

authors： Sondermann H,Soisson SM,Boykevisch S,Yang SS,Bar-Sagi D,Kuriyan J

更新日期：2004-10-29 00:00:00

abstract：:The yeast Sir2/3/4p complex is found in abundance at telomeres, where it participates in the formation of silent heterochromatin and telomere maintenance. Here, we show that Sir3p is released from telomeres in response to DNA double-strand breaks (DSBs), binds to DSBs, and mediates their repair, independent of cell ma...

journal_title：Cell

authors： Mills KD,Sinclair DA,Guarente L

更新日期：1999-05-28 00:00:00

abstract：:Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are tran...

journal_title：Cell

authors： Ioannou MS,Jackson J,Sheu SH,Chang CL,Weigel AV,Liu H,Pasolli HA,Xu CS,Pang S,Matthies D,Hess HF,Lippincott-Schwartz J,Liu Z

更新日期：2019-05-30 00:00:00

abstract：:Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation...

journal_title：Cell

authors： Beelman CA,Parker R

更新日期：1995-04-21 00:00:00

abstract：:We have purified and characterized a modified peptide pheromone that accumulates in culture medium as B. subtilis grows to high density. This pheromone is required for the development of genetic competence. When added to cells at low density, the pheromone induces the premature development of competence. The peptide m...

journal_title：Cell

authors： Magnuson R,Solomon J,Grossman AD

更新日期：1994-04-22 00:00:00

abstract：:Proteolysis is a key regulatory process that promotes the (in)activation, translocation, and/or degradation of proteins. As such, there is considerable interest in methods to comprehensively characterize proteolytic pathways in biological systems. Here, we describe a robust and versatile proteomic platform that enable...

journal_title：Cell

authors： Dix MM,Simon GM,Cravatt BF

更新日期：2008-08-22 00:00:00

abstract：:Understanding molecular mechanisms that dictate B cell diversity is important for targeting B cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in longitudinal samples of patients with breast cancer before and after neoadjuvant chemotherapy, we revealed that an ICOSL+ B cell su...

journal_title：Cell

authors： Lu Y,Zhao Q,Liao JY,Song E,Xia Q,Pan J,Li Y,Li J,Zhou B,Ye Y,Di C,Yu S,Zeng Y,Su S

更新日期：2020-03-19 00:00:00