Abstract：
:While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we identified structural variants altering critical regulators of tumorigenesis and progression not detectable by exome approaches. Notably, we observed amplification of an intergenic enhancer region 624 kb upstream of the androgen receptor (AR) in 81% of patients, correlating with increased AR expression. Tandem duplication hotspots also occur near MYC, in lncRNAs associated with post-translational MYC regulation. Classes of structural variations were linked to distinct DNA repair deficiencies, suggesting their etiology, including associations of CDK12 mutation with tandem duplications, TP53 inactivation with inverted rearrangements and chromothripsis, and BRCA2 inactivation with deletions. Together, these observations provide a comprehensive view of how structural variations affect critical regulators in metastatic prostate cancer.
journal_name
Celljournal_title
Cellauthors
Quigley DA,Dang HX,Zhao SG,Lloyd P,Aggarwal R,Alumkal JJ,Foye A,Kothari V,Perry MD,Bailey AM,Playdle D,Barnard TJ,Zhang L,Zhang J,Youngren JF,Cieslik MP,Parolia A,Beer TM,Thomas G,Chi KN,Gleave M,Lack NA,Zoubedoi
10.1016/j.cell.2018.06.039subject
Has Abstractpub_date
2018-07-26 00:00:00pages
758-769.e9issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(18)30842-0journal_volume
174pub_type
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