Abstract：
:A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led to the evolution of alternative ways for lymphocytes to generate diverse antigen receptors for use in recognizing and repelling pathogen invaders. All jawed vertebrates assemble their antigen-receptor genes through recombinatorial rearrangement of different immunoglobulin or T cell receptor gene segments. The surviving jawless vertebrates, lampreys and hagfish, instead solved the receptor diversification problem by the recombinatorial assembly of leucine-rich-repeat genetic modules to encode variable lymphocyte receptors. The convergent evolution of these remarkably different adaptive immune systems involved innovative genetic modification of innate-immune-system components.
journal_name
Celljournal_title
Cellauthors
Cooper MD,Alder MNdoi
10.1016/j.cell.2006.02.001subject
Has Abstractpub_date
2006-02-24 00:00:00pages
815-22issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(06)00152-8journal_volume
124pub_type
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