Abstract：
:Angiogenesis is an important event for embryonic organogenesis as well as for tissue repair in the adult. Here, we show that hematopoietic stem cells (HSCs) play important roles for angiogenesis during embryogenesis. To investigate the role of HSCs in endothelial cell (EC) development, we analyzed AML1-deficient embryos, which lack definitive hematopoiesis. These embryos showed defective angiogenesis in the head and pericardium. Para-aortic splanchnopleural (P-Sp) explant cultures on stromal cells (P-Sp culture) did not generate definitive hematopoietic cells and showed defective angiogenesis in the AML1 null embryo. Disrupted angiogenesis in P-Sp cultures from AML1 null embryos was rescued by addition of HSCs or angiopoietin-1 (Ang1). HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis.
journal_name
Celljournal_title
Cellauthors
Takakura N,Watanabe T,Suenobu S,Yamada Y,Noda T,Ito Y,Satake M,Suda Tdoi
10.1016/s0092-8674(00)00025-8subject
Has Abstractpub_date
2000-07-21 00:00:00pages
199-209issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(00)00025-8journal_volume
102pub_type
杂志文章相关文献
CELL文献大全abstract：:The molecular basis for membrane association of pp60v-src, the transforming protein of Rous sarcoma virus, was investigated in a cell-free system. Newly synthesized pp60v-src polypeptide, produced by in vitro translation of src mRNA, rapidly bound to plasma membranes. Binding was saturable and dependent on the presenc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90842-8
更新日期：1989-07-28 00:00:00
abstract：:From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a cluster of seven OR genes has been proposed as a trans- and pan-enhance...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.06.023
更新日期：2007-07-27 00:00:00
abstract：:S. cerevisiae strains containing RAS2val19, a RAS2 gene with a missense mutation analogous to one that activates the transforming potential of mammalian ras genes, have growth and biochemical properties strikingly similar to yeast strains carrying IAC or bcy1. Yeast strains carrying the IAC mutation have elevated leve...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90305-8
更新日期：1985-01-01 00:00:00
abstract：:Mechanistic understanding of pre-mRNA splicing requires detailed structural information on various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) structure of the human spliceosome just before exon ligation (the C∗ complex) at an average resolution of 3.76 Å. The splicing factor Prp17...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.04.033
更新日期：2017-05-18 00:00:00
abstract：:The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T cell lymphotropic virus type III (HTLV-III/LAV) was determined. An enhancer element capable of increasing the rate of transcription from a heterologous promoter, irrespective of distance and orientation, is located bet...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(85)80062-3
更新日期：1985-07-01 00:00:00
abstract：:During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00806-7
更新日期：2003-10-17 00:00:00
abstract：:The primer transcript of plasmid ColE1 extends beyond the replication origin in either of two different modes. It does or does not form a hybrid with the template DNA. When a stretch of 20 deoxyadenosine residues is inserted into the template strand downstream of the origin, more than 90% of hybridized transcripts and...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90131-0
更新日期：1987-11-20 00:00:00
abstract：:In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with additional factors to form a small RNA-based immune system that silences mobile elements. Here, we analyzed nine Drosophila piRNA pathway mutants for their impacts on both small RNA populations and the subcellular localization patterns of Piwi ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.03.040
更新日期：2009-05-01 00:00:00
abstract：:Coated vesicles isolated from rat liver perfused with diisopropylfluorophosphate (DFP) to inactivate endogenous cholinesterase contained newly synthesized secretory cholinesterase after a 30 min recovery. The cholinesterase is found in coated vesicles of presumed endocytic origin following DFP treatment and perfusion ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90471-x
更新日期：1986-02-14 00:00:00
abstract：:Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2007.02.009
更新日期：2007-02-23 00:00:00
abstract：:A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81638-4
更新日期：1998-11-25 00:00:00
abstract：:Understanding molecular mechanisms that dictate B cell diversity is important for targeting B cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in longitudinal samples of patients with breast cancer before and after neoadjuvant chemotherapy, we revealed that an ICOSL+ B cell su...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.02.015
更新日期：2020-03-19 00:00:00
abstract：:What happens to organelles during mitosis, and how they are apportioned to each of the daughter cells, is not completely clear. We have devised a procedure to address whether Golgi membranes fuse with the Endoplasmic Reticulum (ER) during mitosis via the detection of interactions between ER and Golgi proteins. This pr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)01068-7
更新日期：2004-01-09 00:00:00
abstract：:DNA carrying inverted repeats was tested for transposition within the Drosophila genome. Five Bam HI segments containing related inverted repeats were isolated from D. melanogaster and analyzed by electron microscopy and restriction mapping. Southern blot experiments using single-copy flanking sequences as probes allo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90310-4
更新日期：1980-07-01 00:00:00
abstract：:The large tumor antigen (LTag) of simian virus 40, an AAA(+) protein, is a hexameric helicase essential for viral DNA replication in eukaryotic cells. LTag functions as an efficient molecular machine powered by ATP binding and hydrolysis for origin DNA melting and replication fork unwinding. To understand how ATP bind...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.09.017
更新日期：2004-10-01 00:00:00
abstract：:In developing organisms, spatially prescribed cell identities are thought to be determined by the expression levels of multiple genes. Quantitative tests of this idea, however, require a theoretical framework capable of exposing the rules and precision of cell specification over developmental time. We use the gap gene...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.01.007
更新日期：2019-02-07 00:00:00
abstract：:Pulses of ecdysteroids direct Drosophila through its life cycle by activating stage- and tissue-specific genetic regulatory hierarchies. Here we show that an orphan nuclear receptor, DHR78, functions at the top of the ecdysteroid regulatory hierarchies. Null mutations in DHR78 lead to lethality during the third larval...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81184-8
更新日期：1998-05-15 00:00:00
abstract：:Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how th...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.11.004
更新日期：2008-11-28 00:00:00
abstract：:Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19(th) century, lineage tracing is now an essential tool for studying stem cell properties in adult mammalian tissues. Lineage tracing provides a powerful means of unde...
journal_title：Cell
pub_type： 历史文章,杂志文章
doi：10.1016/j.cell.2012.01.002
更新日期：2012-01-20 00:00:00
abstract：:Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) family. After duplic...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.09.003
更新日期：2014-09-25 00:00:00
abstract：:K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras ancho...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.11.059
更新日期：2017-01-12 00:00:00
abstract：:Embryonal carcinoma cell lines present strong developmental analogies with early embryonic cells. Previous studies have shown that treatment of F9 teratocarcinoma cells with retinoic acid induces the expression of the classical transplantation antigens which are indispensable for effective interactions between cells. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90179-4
更新日期：1983-12-01 00:00:00
abstract：:In RNA-mediated interference (RNAi), double-stranded RNAs (dsRNAs) target complementary mRNAs for degradation. New work demonstrates that essential chromosomal functions are mediated through RNAi protein components and short RNAs, which alter chromosome function at specific DNA loci via histone modification. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)01039-5
更新日期：2002-10-18 00:00:00
abstract：:Clathrin-mediated endocytosis is a key mechanism by which cells take up extracellular cargo. In this issue, Shimada et al. (2007) reveal the mode of action of the F-BAR domain, which deepens the initial membrane pit that forms during clathrin-mediated endocytosis. ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2007.05.006
更新日期：2007-05-18 00:00:00
abstract：:In target tissues for estrogen, including breast cancer cells, the synthesis of progesterone receptors (PRs) is controlled by estradiol acting through estrogen receptors (ERs). We describe studies with T47D human breast cancer cells, whose PRs are not regulated by estradiol, though present in extraordinary amounts (30...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90218-5
更新日期：1982-03-01 00:00:00
abstract：:Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.05.028
更新日期：2008-06-13 00:00:00
abstract：:Pejvakin (PJVK), a protein originally identified in Persian families with sensorineural hearing loss, regulates peroxisomal dynamics and the antioxidant defense triggered by noise exposure in hair cells and auditory neurons of the inner ear. These findings bring peroxisomes to the forefront of noise-induced hearing lo...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.10.060
更新日期：2015-11-05 00:00:00
abstract：:The promise of human genetics and genomics is nothing less than a fully tailored life, starting with medical treatments, diets, and preventative care all styled around a single genome. There's a lighter side as well where consumer genomics companies are helping people understand themselves and their families. Lara Sze...
journal_title：Cell
pub_type： 面试
doi：10.1016/j.cell.2019.03.002
更新日期：2019-03-21 00:00:00
abstract：:Interactions between transcription factors bound to separate operator sites commonly play an important role in gene regulation by mediating cooperative binding to the DNA. However, few detailed structural models for understanding the molecular basis of such cooperativity are available. The c1 repressor of bacteriophag...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80891-0
更新日期：2000-06-23 00:00:00
abstract：:The function of somatic stem cells declines with age. Understanding the molecular underpinnings of this decline is key to counteract age-related disease. Here, we report a dramatic drop in the neural stem cells (NSCs) number in the aging murine brain. We find that this smaller stem cell reservoir is protected from ful...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.01.040
更新日期：2019-03-07 00:00:00
