R2D2 leads the silencing trigger to mRNA's death star.

Abstract:

:During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi.

journal_name

Cell

journal_title

Cell

authors

Pellino JL,Sontheimer EJ

doi

10.1016/s0092-8674(03)00806-7

subject

Has Abstract

pub_date

2003-10-17 00:00:00

pages

132-3

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092867403008067

journal_volume

115

pub_type

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