Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus.

abstract：:A gel electrophoresis DNA binding assay has been used to identify proteins in HeLa cell extracts that specifically bind to the major late promoter of adenovirus. A major late promoter transcription factor MLTF has been detected as a discrete protein-DNA complex. MLTF binds specifically and with high affinity to sequen...

journal_title：Cell

authors： Carthew RW,Chodosh LA,Sharp PA

更新日期：1985-12-01 00:00:00

abstract：:Goosecoid (gsc), a homeobox gene expressed specifically in the dorsal blastopore lip of the Xenopus gastrula, is considered to play an important role in Spemann's organizer phenomenon. Lineage tracing and time-lapse microscopy were used to follow the fate of embryonic cells microinjected with gsc mRNA. Microinjected g...

journal_title：Cell

authors： Niehrs C,Keller R,Cho KW,De Robertis EM

更新日期：1993-02-26 00:00:00

abstract：:sigma(70) subunit is thought to be released from the core RNA polymerase (RNAP) upon the transition from initiation to elongation or shortly afterward. Here, we identify a population of RNAP from E. coli that retains sigma(70) throughout elongation. The relative amount of this population appears to depend on cellular ...

journal_title：Cell

authors： Bar-Nahum G,Nudler E

更新日期：2001-08-24 00:00:00

abstract：:A transglutaminase-catalyzed cross-linking process characteristic of keratinocytes leads to the formation of the insoluble corneocyte envelope. The essentials of this process take place in vitro in a reconstituted system derived from subcellular fractions. A particulate fraction containing membrane-bound envelope prec...

journal_title：Cell

authors： Simon M,Green H

更新日期：1985-03-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not sufficient for viral entry, which requires fusion between the viral envelope and cell membrane. Here, we show that heparan sulfate modi...

journal_title：Cell

authors： Shukla D,Liu J,Blaiklock P,Shworak NW,Bai X,Esko JD,Cohen GH,Eisenberg RJ,Rosenberg RD,Spear PG

更新日期：1999-10-01 00:00:00

abstract：:Activation of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements (CREs). Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. We show that Ser-117 is also phosphorylated by the mitogen-activat...

journal_title：Cell

authors： de Groot RP,Ballou LM,Sassone-Corsi P

更新日期：1994-10-07 00:00:00

abstract：:The mitochondrial MURF4 gene of T. brucei has pronounced G versus C strand bias and heterogeneously sized transcripts, characteristic of genes encoding extensively edited transcripts. We find that MURF4 transcripts of T. brucei are extensively edited throughout by the addition and deletion of numerous uridines, creati...

journal_title：Cell

authors： Bhat GJ,Koslowsky DJ,Feagin JE,Smiley BL,Stuart K

更新日期：1990-06-01 00:00:00

abstract：:γ-Secretase proteases have been associated with pathology in Alzheimer disease (AD), but we are just beginning to understand their basic mechanisms and physiological roles. A negative drug trial with a broad spectrum γ-secretase inhibitor in AD patients has severely dampened enthusiasm for the potential of pursuing γ-...

journal_title：Cell

authors： De Strooper B

更新日期：2014-11-06 00:00:00

abstract：:Several recent papers show that differences in histone modification and the use of histone variants at the 5' and 3' ends of genes influence the location and kinetics of transcriptional initiation. The ultimate target of most epigenetic mechanisms may be the regulation of nucleosome occupancy, which in turn controls a...

journal_title：Cell

authors： Lieb JD,Clarke ND

更新日期：2005-12-29 00:00:00

abstract：:The sulfated glycosaminoglycan, heparin, was found to release 125I-labeled low density lipoprotein (125I-LDL) from its receptor site on the surface of normal human fibroblasts. Measurement of the amount of 125I-LDL released by heparin permitted the resolution of the total cellular uptake of 125I-LDL at 37 degrees C in...

journal_title：Cell

authors： Goldstein JL,Basu SK,Brunschede GY,Brown MS

更新日期：1976-01-01 00:00:00

abstract：:S. cerevisiae inherits its vacuole by projecting vacuole-derived membrane vesicles and tubules into the bud, where they fuse to establish the daughter vacuole. This homotypic fusion event can be assayed in vitro. It requires Sec17p and Sec18p, the homologs of the mammalian alpha-SNAP and NSF, which cooperate in multip...

journal_title：Cell

authors： Mayer A,Wickner W,Haas A

更新日期：1996-04-05 00:00:00

abstract：:In embryos of X. laevis, and many other species, early development requires targeted movements of molecules and molecular aggregates within the oocyte or egg cytoplasm. One well-known example in Xenopus is the aggregation of germ plasm, a group of cytoplasmic islands that become distributed during the first few cell c...

journal_title：Cell

authors： Robb DL,Heasman J,Raats J,Wylie C

更新日期：1996-11-29 00:00:00

abstract：:Pseudomonas exotoxin (PE) was used as a probe to study the mechanism by which protein ligands are internalized by mammalian cells. Both biochemical and electron microscopic methods were used to look at the internalization of PE by mouse LM cell fibroblasts. Our data suggest that PE enters cells by receptor-mediated en...

journal_title：Cell

authors： FitzGerald D,Morris RE,Saelinger CB

更新日期：1980-10-01 00:00:00

abstract：:The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1. Homozygous mutants die at embryonic day 16.5. Their phenotype includes severe craniofac...

journal_title：Cell

authors： Cecconi F,Alvarez-Bolado G,Meyer BI,Roth KA,Gruss P

更新日期：1998-09-18 00:00:00

abstract：:In induced erythroleukemia cells, transcription of the beta-globin gene terminates in a region 600-1500 nucleotides downstream of the poly(A) site. To determine whether this region of the mouse DNA functions to terminate transcription when moved to another genomic site, portions of the putative termination region have...

journal_title：Cell

authors： Falck-Pedersen E,Logan J,Shenk T,Darnell JE Jr

更新日期：1985-04-01 00:00:00

abstract：:To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the ...

journal_title：Cell

authors： Hu J,Hwang SS,Liesa M,Gan B,Sahin E,Jaskelioff M,Ding Z,Ying H,Boutin AT,Zhang H,Johnson S,Ivanova E,Kost-Alimova M,Protopopov A,Wang YA,Shirihai OS,Chin L,DePinho RA

更新日期：2012-02-17 00:00:00

abstract：:G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes by multidimensional protein interaction technology (MudPIT). Whi5 was identified as a stably bound component of SBF but not MBF. Inactiv...

journal_title：Cell

authors： de Bruin RA,McDonald WH,Kalashnikova TI,Yates J 3rd,Wittenberg C

更新日期：2004-06-25 00:00:00

abstract：:Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin. Vitellogenin synthesis, as a primary response, is first detectable on the fourth day of culture, and comprises up to 12% of the protein synthesiz...

journal_title：Cell

authors： Green CD,Tata JR

更新日期：1976-01-01 00:00:00

abstract：:Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oc...

journal_title：Cell

authors： Strubin M,Newell JW,Matthias P

更新日期：1995-02-10 00:00:00

abstract：:Nutrition presents unanswered scientific questions of high public health importance. We envision model systems composed of interacting gastrointestinal and metabolic tissues derived from human embryonic stem cells, populated by gut microbiota. The culture will be embedded in 3D scaffolds, creating a controlled experim...

journal_title：Cell

authors： Ben-Zvi D,Melton DA

更新日期：2015-03-26 00:00:00

abstract：:As axons grow past intermediate targets, they change their responsiveness to guidance cues. Local upregulation of receptor expression is involved, but the mechanisms for this are not clear. Here protein synthesis is traced within individual axons by introducing RNAs encoding visualizable reporters. Individual severed ...

journal_title：Cell

authors： Brittis PA,Lu Q,Flanagan JG

更新日期：2002-07-26 00:00:00

abstract：:Motile cells extend a leading edge by assembling a branched network of actin filaments that produces physical force as the polymers grow beneath the plasma membrane. A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematica...

journal_title：Cell

authors： Pollard TD,Borisy GG

更新日期：2003-02-21 00:00:00

abstract：:In extracts from rat and calf uterus, the steroid hormone 17 beta-estradiol stimulates the binding of its specific receptor protein to DNA. This interaction appears to be of low affinity (half of the estradiol-activated, 5S receptor bound at 300-400 mug/ml DNA) and nonspecific with respect to DNA base sequence. No bin...

journal_title：Cell

authors： Yamamoto K,Alberts B

更新日期：1975-04-01 00:00:00

abstract：:Gastrulation is a complex process requiring the coordination of cell shape changes and cell movements. In Drosophila, gastrulation begins immediately upon cellularization of the blastoderm stage embryo with the formation of the ventral furrow and posterior midgut. Cells that form both of these invaginations change the...

journal_title：Cell

authors： Parks S,Wieschaus E

更新日期：1991-01-25 00:00:00

abstract：:We show that the high in vitro transcription efficiency of yeast RNA pol III is mainly due to rapid recycling. Kinetic analysis shows that RNA polymerase recycling on preassembled tDNA.TFIIIC.TFIIIB complexes is much faster than the initial transcription cycle. High efficiency of RNA pol III recycling is favored at hi...

journal_title：Cell

authors： Dieci G,Sentenac A

更新日期：1996-01-26 00:00:00

abstract：:The tumor suppressor gene p53 regulates multiple cellular responses to DNA damage, but the transcriptional targets that specify these responses are incompletely understood. We describe a Drosophila p53 homolog and demonstrate that it can activate transcription from a promoter containing binding sites for human p53. Do...

journal_title：Cell

authors： Brodsky MH,Nordstrom W,Tsang G,Kwan E,Rubin GM,Abrams JM

更新日期：2000-03-31 00:00:00

abstract：:xol-1 is the earliest-acting gene in the known hierarchy that controls C. elegans sex determination and dosage compensation. We show that the primary sex-determining signal (the X/A ratio) directs the choice of sexual fate by regulating xol-1 transcript levels: high xol-1 expression during gastrulation triggers male d...

journal_title：Cell

authors： Rhind NR,Miller LM,Kopczynski JB,Meyer BJ

更新日期：1995-01-13 00:00:00

abstract：:Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report here two kindreds with autoimmune lymphoproliferative syndrome (ALPS) type II, characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects, that harbor...

journal_title：Cell

authors： Wang J,Zheng L,Lobito A,Chan FK,Dale J,Sneller M,Yao X,Puck JM,Straus SE,Lenardo MJ

更新日期：1999-07-09 00:00:00

abstract：:The advent of H7N9 in early 2013 is of concern for a number of reasons, including its capability to infect humans, the lack of clarity in the etiology of infection, and because the human population does not have pre-existing immunity to the H7 subtype. Earlier sequence analyses of H7N9 hemagglutinin (HA) point to amin...

journal_title：Cell

authors： Tharakaraman K,Jayaraman A,Raman R,Viswanathan K,Stebbins NW,Johnson D,Shriver Z,Sasisekharan V,Sasisekharan R

更新日期：2013-06-20 00:00:00

abstract：:Rubisco, the key enzyme of CO2 fixation in photosynthesis, is prone to inactivation by inhibitory sugar phosphates. Inhibited Rubisco undergoes conformational repair by the hexameric AAA+ chaperone Rubisco activase (Rca) in a process that is not well understood. Here, we performed a structural and mechanistic analysis...

journal_title：Cell

authors： Flecken M,Wang H,Popilka L,Hartl FU,Bracher A,Hayer-Hartl M

更新日期：2020-10-15 00:00:00