Abstract：
:The mitochondrial MURF4 gene of T. brucei has pronounced G versus C strand bias and heterogeneously sized transcripts, characteristic of genes encoding extensively edited transcripts. We find that MURF4 transcripts of T. brucei are extensively edited throughout by the addition and deletion of numerous uridines, creating potential initiation and termination codons and a continuous open reading frame. A potential guide RNA sequence occurs in a minicircle between inverted repeats. The 5' region of L. tarentolae MURF4 transcripts is also extensively edited, with a created initiation codon. The predicted MURF4 amino acid sequences have homology to those of mitochondrial ATP-ase subunit 6 genes from a variety of organisms. In addition, their hydropathic profiles are quite similar to those of other species. We therefore conclude that MURF4 encodes ATPase subunit 6 genes.
journal_name
Celljournal_title
Cellauthors
Bhat GJ,Koslowsky DJ,Feagin JE,Smiley BL,Stuart Kdoi
10.1016/0092-8674(90)90199-osubject
Has Abstractpub_date
1990-06-01 00:00:00pages
885-94issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(90)90199-Ojournal_volume
61pub_type
杂志文章相关文献
CELL文献大全abstract：:Exchange factors for ARF GTPases (ARF-GEFs) regulate vesicle trafficking in a variety of organisms. The Arabidopsis protein GNOM is a brefeldin A (BFA) sensitive ARF-GEF that is required for the proper polar localization of PIN1, a candidate transporter of the plant hormone auxin. Mutations in GNOM lead to development...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00003-5
更新日期：2003-01-24 00:00:00
abstract：:We have identified a 2.4 kb partial cDNA clone (pDL34) for human von Willebrand factor (vWf) mRNA. pDL34 was selected by screening an endothelial cell cDNA library with a radiolabeled reverse transcript of mRNA obtained by specific immunoisolation of vWf polysomes from endothelial cells. pDL34 selectively hybridized t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90060-1
更新日期：1985-05-01 00:00:00
abstract：:Hybrids between mouse hepatoma cells (which secrete several serum proteins) and mouse or rat fibroblasts (which do not secrete these proteins) produce transferrin and the third component of complement (C3) like the parental hepatoma cells, while they do not secrete either albumin or alpha-fetoprotein (AFP). This lack ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90073-2
更新日期：1975-09-01 00:00:00
abstract：:Plants, compared to animals, exhibit an amazing adaptability and plasticity in their development. This is largely dependent on the ability of plants to form new organs, such as lateral roots, leaves, and flowers during postembryonic development. Organ primordia develop from founder cell populations into organs by coor...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00924-3
更新日期：2003-11-26 00:00:00
abstract：:In this issue, Frey and Görlich (2007) provide new insight into the selective barrier that controls protein traffic through the nuclear pore complex. They show that a single protein domain of the nuclear pore protein Nsp1 can form a hydrogel that allows highly selective access of nuclear transport receptors and their ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2007.07.029
更新日期：2007-08-10 00:00:00
abstract：:Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging in Drosophila. We show that inhibition of Ras is sufficient for lifespan extension downstream of reduced...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.06.023
更新日期：2015-07-02 00:00:00
abstract：:Cadherins are a group of homophilic intercellular adhesion molecules; each member of this family exhibits binding specificity. Here, we attempted to map the sites for the specificities of these molecules by analyzing adhesives selectivities of the cells that express chimeric and point-mutated E- and P-cadherin. The re...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90222-z
更新日期：1990-04-06 00:00:00
abstract：:In this issue, Baumann et al. (2007) identify a helicase PICH that localizes to "threads" that remain connected between sister kinetochores after they have separated in anaphase. These threads are thought to be catenated centromeric DNA. PICH contributes to the mitotic checkpoint by recruiting Mad2 to kinetochores and...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2006.12.022
更新日期：2007-01-12 00:00:00
abstract：:The sigma factor sigma 70 of E. coli RNA polymerase acts not only in initiation, but also at an early stage of elongation to induce a transcription pause, and simultaneously to allow the phage lambda gene Q transcription antiterminator to act. We identify the signal in DNA that induces early pausing to be a version of...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80121-x
更新日期：1996-08-09 00:00:00
abstract：:Vanadate has been shown to inhibit phosphatases that remove phosphate groups from phosphotyrosine in cell-free systems. Addition of vanadate to the culture medium of NRK-1 cells resulted in a maximal 40-fold increase in the level of phosphotyrosine in cell protein. Also, vanadate induced transformation as evidenced by...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(85)80051-9
更新日期：1985-07-01 00:00:00
abstract：:Cortical layer 1 (L1) interneurons have been proposed as a hub for attentional modulation of underlying cortex, but the transformations that this circuit implements are not known. We combined genetically targeted voltage imaging with optogenetic activation and silencing to study the mechanisms underlying sensory proce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.01.001
更新日期：2020-02-06 00:00:00
abstract：:The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81050-8
更新日期：1996-03-08 00:00:00
abstract：:Membrane scission is essential for intracellular trafficking. While BAR domain proteins such as endophilin have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanism has yet to be deciphered. Here, we combine a theoretical model, in vitro, and in vivo experiments revealing how ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.05.047
更新日期：2017-06-29 00:00:00
abstract：:Mitochondrial DNA is compacted into nucleoprotein complexes denoted mitochondrial nucleoids, the focus of this SnapShot. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2017.12.039
更新日期：2018-01-11 00:00:00
abstract：:Dysregulation of splicing and alternative splicing underlies many genetic and acquired diseases. We present an overview of recent strategies and successes in modulating splicing therapeutically in clinical and preclinical contexts. Effective approaches include restoring open reading frames, influencing alternative spl...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2012.02.014
更新日期：2012-03-16 00:00:00
abstract：:Chronic viral infections represent a major burden to human health, and modulation of the immune system is emerging as a novel approach to fighting such infections. Pellegrini et al. (2011) demonstrate that treatment with the cytokine IL-7 may reinvigorate the immune response to persistent infection by targeting immuno...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.01.038
更新日期：2011-02-18 00:00:00
abstract：:Determining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from over 12,000 genes across 32 normal human tissues. Tissue-specific or tissue...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.08.036
更新日期：2020-10-01 00:00:00
abstract：:We describe a monoclonal antibody directed against a neuron-specific mitochondrial protein from rat brain. On protein blots the antibody recognizes a single polypeptide of apparent molecular weight of 23,000. By solid-phase immunoassay the antigen was detected in nonneural tissues. Within neurons, the antibody stains ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90343-9
更新日期：1982-02-01 00:00:00
abstract：:Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are tran...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.04.001
更新日期：2019-05-30 00:00:00
abstract：:The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously. We report here the biochemical purification and subsequent molecular cloning of two novel TNFR2-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90149-3
更新日期：1995-12-29 00:00:00
abstract：:The alpha IIb beta 3 integrin binds Arg-Gly-Asp-containing (RGD-containing) ligands in a cation-dependent interaction. A fourteen amino acid sequence, beta 3 (118-131), and an antibody to it, inhibited ligand binding functions of alpha IIb beta 3, and a 1:1 stoichiometric beta 3 (118-131)-RGD complex was detected by m...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90551-7
更新日期：1994-11-18 00:00:00
abstract：:The Drosophila transforming growth factor beta (TGF-beta) homolog Decapentaplegic (Dpp) acts as a morphogen that forms a long-range concentration gradient to direct the anteroposterior patterning of the wing. Both planar transcytosis initiated by Dynamin-mediated endocytosis and extracellular diffusion have been propo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.09.031
更新日期：2004-10-15 00:00:00
abstract：:The phenotype of the autosomal recessive mutation scat includes severe intermittent bleeding, depletion of platelets, and circulating anti-platelet antibodies. In this study, we have mapped the scat mutation to mouse chromosome 8 and shown that the immune component is a secondary consequence of the gene defect. Surpri...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90301-6
更新日期：1993-07-16 00:00:00
abstract：:Transcriptional pausing by multisubunit RNA polymerases (RNAPs) is a key mechanism for regulating gene expression in both prokaryotes and eukaryotes and is a prerequisite for transcription termination. Pausing and termination states are thought to arise through a common, elemental pause state that is inhibitory for nu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.12.020
更新日期：2013-01-31 00:00:00
abstract：:DNA fragments containing the silencers that flank the mating type genes at HML alpha are shown to bind specifically to the nuclear scaffold of yeast. The scaffold proteins are solubilized with urea and then renatured to form a soluble extract which allows reconstitution of sequence-specific DNA loops. At the silent ma...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90788-5
更新日期：1989-06-02 00:00:00
abstract：:Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2008.01.007
更新日期：2008-01-25 00:00:00
abstract：:Fluorescent proteins are commonly used to label cells across organisms, but the unmodified forms cannot control biological activities. Using GFP-binding proteins derived from Camelid antibodies, we co-opted GFP as a scaffold for inducing formation of biologically active complexes, developing a library of hybrid transc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.07.021
更新日期：2013-08-15 00:00:00
abstract：:Neurodegenerative diseases can occur so early as to affect neurodevelopment. From a cohort of more than 2,000 consanguineous families with childhood neurological disease, we identified a founder mutation in four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1). CLP1 is a multifunctional ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.03.049
更新日期：2014-04-24 00:00:00
abstract：:γ-Secretase proteases have been associated with pathology in Alzheimer disease (AD), but we are just beginning to understand their basic mechanisms and physiological roles. A negative drug trial with a broad spectrum γ-secretase inhibitor in AD patients has severely dampened enthusiasm for the potential of pursuing γ-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.10.016
更新日期：2014-11-06 00:00:00
abstract：:Understanding the physiology and genetics of human hypoxia tolerance has important medical implications, but this phenomenon has thus far only been investigated in high-altitude human populations. Another system, yet to be explored, is humans who engage in breath-hold diving. The indigenous Bajau people ("Sea Nomads")...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.03.054
更新日期：2018-04-19 00:00:00
