Abstract：
:The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously. We report here the biochemical purification and subsequent molecular cloning of two novel TNFR2-associated proteins, designated c-IAP1 and c-IAP2, that are closely related mammalian members of the inhibitor of apoptosis protein (IAP) family originally identified in baculoviruses. The viral and cellular IAPs contain N-terminal baculovirus IAP repeat (BIR) motifs and a C-terminal RING finger. The c-IAPs do not directly contact TNFR2, but rather associate with TRAF1 and TRAF2 through their N-terminal BIR motif-comprising domain. The recruitment of c-IAP1 or c-IAP2 to the TNFR2 signaling complex requires a TRAF2-TRAF1 heterocomplex.
journal_name
Celljournal_title
Cellauthors
Rothe M,Pan MG,Henzel WJ,Ayres TM,Goeddel DVdoi
10.1016/0092-8674(95)90149-3subject
Has Abstractpub_date
1995-12-29 00:00:00pages
1243-52issue
7eissn
0092-8674issn
1097-4172pii
0092-8674(95)90149-3journal_volume
83pub_type
杂志文章相关文献
CELL文献大全abstract：:Cytokine-activated receptors initiate intracellular signaling by recruiting protein kinases that phosphorylate the receptors on tyrosine residues, thus enabling docking of SH2 domain-bearing activating factors. Here we report that in response to type 1 interferon (IFNalpha), IFNalpha receptors recruit cytoplasmic CREB...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.07.034
更新日期：2007-10-05 00:00:00
abstract：:Sucrose gradient analysis of DNA isolated from detergent-pronase lysates of adult flies has been used to look for ribosomal genes not integrated into the DNA of the chromosome in genotypes containing various combinations of inversions having breakpoints in the proximal heterochromatin of the X chromosome. Unintegrated...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90056-3
更新日期：1977-06-01 00:00:00
abstract：:Loss-of-function diseases are often caused by a mutation in a protein traversing the secretory pathway that compromises the normal balance between protein folding, trafficking, and degradation. We demonstrate that the innate cellular protein homeostasis, or proteostasis, capacity can be enhanced to fold mutated enzyme...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.06.037
更新日期：2008-09-05 00:00:00
abstract：:Plasmids expressing partial-length sense or antisense protein 4.1 RNA were microinjected into fertilized Xenopus eggs. Nuclease protection assays reveal that antisense protein 4.1 RNA lead to the specific loss of endogenous protein 4.1 transcripts after midblastula transition, with no effect on the levels of three unr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90576-4
更新日期：1988-05-20 00:00:00
abstract：:P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants. We have found that a short segment near the amino terminus of PSGL-1 that contains a tyrosine sulfation consensus is essential for P-selectin adhesion and that...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90174-4
更新日期：1995-10-20 00:00:00
abstract：:On each side of the midline of the Drosophila CNS, axons are organized into a series of parallel pathways. Here we show that the midline repellent Slit, previously identified as a short-range signal that regulates midline crossing, also functions at long range to pattern these longitudinal pathways. In this long-range...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)00207-5
更新日期：2000-12-22 00:00:00
abstract：:We present an integrated analysis of the clinical measurements, immune cells, and plasma multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial blood draws collected during the first week of infection following diagnosis. We identify a major shift between mild and moderate diseas...
journal_title：Cell
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.cell.2020.10.037
更新日期：2020-12-10 00:00:00
abstract：:K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras ancho...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.11.059
更新日期：2017-01-12 00:00:00
abstract：:Yeast ataxin-2, also known as Pbp1 (polyA binding protein-binding protein 1), is an intrinsically disordered protein implicated in stress granule formation, RNA biology, and neurodegenerative disease. To understand the endogenous function of this protein, we identify Pbp1 as a dedicated regulator of TORC1 signaling an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.02.043
更新日期：2019-04-18 00:00:00
abstract：:The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and renal function and is an important model for studies of G-protein-coupled receptor (GPCR) signaling. By stabilizing the receptor with a single-domain antibody fragment ("nanobody") discovered using a synthetic yeast-display...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.12.006
更新日期：2019-01-24 00:00:00
abstract：:Synergistic bispecific antibodies against HIV exhibit extraordinary potency and breadth of neutralization as promising candidates for treatment and prevention. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.06.004
更新日期：2016-06-16 00:00:00
abstract：:Xenopus laevis oocytes respond to high temperature (greater than 31 degrees C) by the synthesis of one major (70 kilodalton) protein and by a gradual reduction in the rate of normal protein synthesis. In contrast with most other cells, the heat-shock response of Xenopus oocytes is controlled exclusively at the transla...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90443-3
更新日期：1982-07-01 00:00:00
abstract：:The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells....
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.08.016
更新日期：2014-09-25 00:00:00
abstract：:Three membrane microdomains can be identified on docked vacuoles: "outside" membrane, not in contact with other vacuoles, "boundary" membrane that contacts adjacent vacuoles, and "vertices," where boundary and outside membrane meet. In living cells and in vitro, vacuole fusion occurs at vertices rather than from a cen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00632-3
更新日期：2002-02-08 00:00:00
abstract：:Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac mu...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.08.004
更新日期：2010-08-20 00:00:00
abstract：:The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al. (2008) demonstrate that the endosomal protein Appl1 modulat...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.04.015
更新日期：2008-05-02 00:00:00
abstract：:Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitive method to tag and track pancreatic epithelial cells in a mouse model of pancreatic cancer. Tagged cells invaded and enter...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.11.025
更新日期：2012-01-20 00:00:00
abstract：:The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81771-7
更新日期：1998-10-30 00:00:00
abstract：:Methylation of deoxycytidine incorporated by DNA excision-repair was studied in human diploid fibroblasts following damage with ultraviolet radiation, N-methyl-N-nitrosourea, or N-acetoxy-2-acetylaminofluorene. In confluent, nondividing cells, methylation in repair patches induced by all three agents is slow and incom...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90248-3
更新日期：1982-09-01 00:00:00
abstract：:A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.04.039
更新日期：2010-06-11 00:00:00
abstract：:The frequencies of transformations of primary human and Chinese hamster fibroblasts have been compared with the spontaneous and induced frequencies of mutation for resistance to thioguanine and ouabain, and for ability to use fructose, using the carcinogens benzo (alpha) pyrene and urethane. Whereas the rates and freq...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90215-5
更新日期：1978-04-01 00:00:00
abstract：:DNA repair is an essential process for preserving genome integrity in all organisms. In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into centers (foci). Here, we analyze the cellular response to DNA double-strand breaks (DSBs) and replication stress in Saccharomyces...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.08.015
更新日期：2004-09-17 00:00:00
abstract：:Cell-cell junctions respond to mechanical forces by changing their organization and function. To gain insight into the mechanochemical basis underlying junction mechanosensitivity, we analyzed tight junction (TJ) formation between the enveloping cell layer (EVL) and the yolk syncytial layer (YSL) in the gastrulating z...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.10.006
更新日期：2019-10-31 00:00:00
abstract：:A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2006.02.001
更新日期：2006-02-24 00:00:00
abstract：:A distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious heat. Here ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00652-9
更新日期：2002-03-08 00:00:00
abstract：:We have identified two major and approximately ten minor poly(A)-containing RNA species in S. cerevisiae which arise from in vivo transcription of the yeast plasmid, known as 2mu circle. The two major species, which are 1325 and 1275 bases in length, are transcribed from the two unique halves of the plasmid and extend...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90098-9
更新日期：1979-04-01 00:00:00
abstract：:Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regene...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.02.016
更新日期：2015-04-09 00:00:00
abstract：:We have generated mice lacking H2-M complexes, critical facilitators of peptide loading onto major histo-compatibility complex class II molecules. Ab molecules in these mice matured into stable complexes and were efficiently expressed at the cell surface. Most carried a single peptide derived from the class II-associa...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81029-6
更新日期：1996-02-23 00:00:00
abstract：:In vertebrates, muscles of the limbs and body wall derive from the lateral compartment of the embryonic somites, and axial muscles derive from the medial compartment. Whereas the mechanisms that direct patterning of somites along the dorsoventral axis are beginning to be understood, little is known about the tissue in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81291-x
更新日期：1996-02-09 00:00:00
abstract：:The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain unbundled microtubule filaments, suggesting that localized activation of microtubule-associated proteins (MAP) at the transition zone may bundle these filaments during axonal growth. Dephosphorylation is thought to lead t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.03.023
更新日期：2007-05-04 00:00:00
