Abstract：
:Xenopus laevis oocytes respond to high temperature (greater than 31 degrees C) by the synthesis of one major (70 kilodalton) protein and by a gradual reduction in the rate of normal protein synthesis. In contrast with most other cells, the heat-shock response of Xenopus oocytes is controlled exclusively at the translational level. Enucleated or alpha-amanitin-injected oocytes synthesize normal levels of heat-shock protein. Thus high temperature induces the translation of preformed heat-shock mRNA. This continues for more than a day after a shift back to a normal temperature, but ceases within 2 days. Heat-shock protein synthesis can be sequentially induced and inactivated in the same oocyte over several days. We conclude that an oocyte contains 10-100 pg of heat-shock mRNA, which is synthesized during oogenesis at the normal temperature, and which is stored in an inactive state by a "masking" mechanism.
journal_name
Celljournal_title
Cellauthors
Bienz M,Gurdon JBdoi
10.1016/0092-8674(82)90443-3subject
Has Abstractpub_date
1982-07-01 00:00:00pages
811-9issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(82)90443-3journal_volume
29pub_type
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