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Abate and switch: miR-145 in stem cell differentiation.

Abstract：

:MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.

journal_name

Cell

journal_title

Cell

authors

Chivukula RR,Mendell JT

doi

10.1016/j.cell.2009.04.059

subject

Has Abstract

pub_date

2009-05-15 00:00:00

pages

606-8

issue

4

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(09)00520-0

journal_volume

137

pub_type

评论,杂志文章

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