Chromatin connections to pluripotency and cellular reprogramming.

abstract：:The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...

journal_title：Cell

authors： Heindell HC,Liu A,Paddock GV,Studnicka GM,Salser WA

更新日期：1978-09-01 00:00:00

abstract：:Trypanosoma brucei variant surface glycoprotein (VSG) genes are activated either by duplicative (DA) transposition of the gene to a pre-activated expression site or by nonduplicative (NDA) activation of a previously silent telomeric gene. We have obtained a recombinant clone spanning the 5' barren region of the expres...

journal_title：Cell

authors： Cully DF,Ip HS,Cross GA

更新日期：1985-08-01 00:00:00

abstract：:Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. We have produced three lines of transgenic mice carrying a calmodulin minigene regulated by the rat insulin II promoter. Immunohistochemistry and hybridization analyses in...

journal_title：Cell

authors： Epstein PN,Overbeek PA,Means AR

更新日期：1989-09-22 00:00:00

abstract：:Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane ...

journal_title：Cell

authors： Malmersjö S,Meyer T

更新日期：2013-06-20 00:00:00

abstract：:The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tiss...

journal_title：Cell

authors： Stathopoulos A,Van Drenth M,Erives A,Markstein M,Levine M

更新日期：2002-11-27 00:00:00

abstract：:The primer transcript of plasmid ColE1 extends beyond the replication origin in either of two different modes. It does or does not form a hybrid with the template DNA. When a stretch of 20 deoxyadenosine residues is inserted into the template strand downstream of the origin, more than 90% of hybridized transcripts and...

journal_title：Cell

authors： Tomizawa J,Masukata H

更新日期：1987-11-20 00:00:00

abstract：:Polyadenylation of mRNA precursors by poly(A) polymerase depends on a specificity factor, CPF, recognizing the polyadenylation signal AAUAAA. This paper describes an apparently novel poly(A)-binding protein that acts as a second specificity factor, mediating the recognition of the growing poly(A) tail. A transition fr...

journal_title：Cell

authors： Wahle E

更新日期：1991-08-23 00:00:00

abstract：:We have determined the nucleotide sequences of the germ line gene as well as a corresponding somatically mutated and rearranged gene coding for a mouse immunoglobulin lambdaI type light chain. These sequencing studies were carried out on three Eco RI-DNA fragments which had been cloned from BALB/c mouse embryos or a l...

journal_title：Cell

authors： Bernard O,Hozumi N,Tonegawa S

更新日期：1978-12-01 00:00:00

abstract：:We examined the interactions of lipid vesicles (liposomes) labeled with various fluorescent markers with the intracellular membranes of semi-intact ("perforated") fibroblasts. When incubations were performed in the presence of an ATP-regenerating system, both vesicle lipids and entrapped water soluble markers were tra...

journal_title：Cell

authors： Kobayashi T,Pagano RE

更新日期：1988-12-02 00:00:00

abstract：:Morphogen gradients control body pattern by differentially regulating cellular behavior. Here, we analyze the molecular events underlying the primary response to the Dpp/BMP morphogen in Drosophila. Throughout development, Dpp transduction causes the graded transcriptional downregulation of the brinker (brk) gene. We ...

journal_title：Cell

authors： Müller B,Hartmann B,Pyrowolakis G,Affolter M,Basler K

更新日期：2003-04-18 00:00:00

abstract：:Cholera toxin inhibition of progesterone-induced meiosis of Xenopus laevis oocytes in vitro has been correlated with increased cAMP levels. Inhibition of germinal vesicle breakdown (Gvbd) and cAMP increase occurred after a lag period of 2 hr, when cholera toxin was injected, or 4--5 hr, when applied externally. The ab...

journal_title：Cell

authors： Schorderet-Slatkine S,Schorderet M,Boquet P,Godeau F,Baulieu EE

更新日期：1978-12-01 00:00:00

abstract：:Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate their assembly, substructure, and coexistence with other liquid-like compartments remain elusive. Here, we address the biophysical mechanism of this multiphase o...

journal_title：Cell

authors： Sanders DW,Kedersha N,Lee DSW,Strom AR,Drake V,Riback JA,Bracha D,Eeftens JM,Iwanicki A,Wang A,Wei MT,Whitney G,Lyons SM,Anderson P,Jacobs WM,Ivanov P,Brangwynne CP

更新日期：2020-04-16 00:00:00

abstract：:Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuro...

journal_title：Cell

authors： Krashes MJ,DasGupta S,Vreede A,White B,Armstrong JD,Waddell S

更新日期：2009-10-16 00:00:00

abstract：:Salmonella possesses several flagella, each capable of counterclockwise and clockwise rotation. Counterclockwise rotation produces swimming, clockwise rotation produces tumbling. Switching between senses occurs stochastically. The rotational sense of individual flagella on a single cell could be monitored under specia...

journal_title：Cell

authors： Macnab RM,Han DP

更新日期：1983-01-01 00:00:00

abstract：:DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks conver...

journal_title：Cell

authors： Räschle M,Knipscheer P,Enoiu M,Angelov T,Sun J,Griffith JD,Ellenberger TE,Schärer OD,Walter JC

更新日期：2008-09-19 00:00:00

abstract：:Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host...

journal_title：Cell

authors： Chevalier C,Stojanović O,Colin DJ,Suarez-Zamorano N,Tarallo V,Veyrat-Durebex C,Rigo D,Fabbiano S,Stevanović A,Hagemann S,Montet X,Seimbille Y,Zamboni N,Hapfelmeier S,Trajkovski M

更新日期：2015-12-03 00:00:00

abstract：:Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immu...

journal_title：Cell

authors： Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Sch

更新日期：2018-01-11 00:00:00

abstract：:AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/GluR2 receptors are ...

journal_title：Cell

authors： Shi S,Hayashi Y,Esteban JA,Malinow R

更新日期：2001-05-04 00:00:00

abstract：:Plants greatly rely on their root microbiome for uptake of nutrients and protection against stresses. Recent studies have uncovered the involvement of plant stress responses in the assembly of plant-beneficial microbiomes. To facilitate durable crop production, deciphering the driving forces that shape the microbiome ...

journal_title：Cell

authors： Bakker PAHM,Pieterse CMJ,de Jonge R,Berendsen RL

更新日期：2018-03-08 00:00:00

abstract：:The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the u...

journal_title：Cell

authors： Deverman BE,Cook BL,Manson SR,Niederhoff RA,Langer EM,Rosová I,Kulans LA,Fu X,Weinberg JS,Heinecke JW,Roth KA,Weintraub SJ

更新日期：2002-10-04 00:00:00

abstract：:Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). However, the phosphorylation events critical for tau toxicity and mechanisms regulating these events are largely unknown. Here we show that Drosophila PAR-1 kinase initiates t...

journal_title：Cell

authors： Nishimura I,Yang Y,Lu B

更新日期：2004-03-05 00:00:00

abstract：:The discovery that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) raised the exciting possibility of modeling diseases with patient-specific cells. Marchetto et al. (2010) now use iPSC technology to generate, characterize, and treat an in vitro model for the autism spectrum disorder Rett...

journal_title：Cell

authors： Walsh RM,Hochedlinger K

更新日期：2010-11-12 00:00:00

abstract：:The nucleotide sequence from the 5' terminus inward of one third of mouse alpha- and beta maj-globin messenger RNAs has been established. In addition, using 5' 32P end-labeled mRNAs as substrates and S1 and T1 nucleases as probes for single-stranded regions, the secondary structures of mouse and rabbit alpha- and beta...

journal_title：Cell

authors： Pavlakis GN,Lockard RE,Vamvakopoulos N,Rieser L,RajBhandary UL,Vournakis JN

更新日期：1980-01-01 00:00:00

abstract：:Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a mo...

journal_title：Cell

authors： Godar M,Lambrecht BN

更新日期：2016-01-14 00:00:00

abstract：:The role of electricity in biological systems was first appreciated through electrical stimulation experiments performed by Luigi Galvani in the 18th century. These pioneering experiments demonstrated that the behavior of living tissues is governed by the flow of electrochemical species-an insight that gave rise to th...

journal_title：Cell

authors： Lee DD,Prindle A,Liu J,Süel GM

更新日期：2017-06-29 00:00:00

abstract：:The rate-limiting enzyme of cholesterol biosynthesis, HMG CoA reductase, is controlled by negative feedback regulation of transcription. We have isolated the reductase gene from a bacteriophage lambda genomic library prepared from hamster UT-1 cells. The 25 kilobase gene is split into 20 exons. The 5' untranslated and...

journal_title：Cell

authors： Reynolds GA,Basu SK,Osborne TF,Chin DJ,Gil G,Brown MS,Goldstein JL,Luskey KL

更新日期：1984-08-01 00:00:00

abstract：:Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I-...

journal_title：Cell

authors： Chan SH,Cosgrove D,Waltzinger C,Benoist C,Mathis D

更新日期：1993-04-23 00:00:00

abstract：:The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvi...

journal_title：Cell

authors： Boice M,Salloum D,Mourcin F,Sanghvi V,Amin R,Oricchio E,Jiang M,Mottok A,Denis-Lagache N,Ciriello G,Tam W,Teruya-Feldstein J,de Stanchina E,Chan WC,Malek SN,Ennishi D,Brentjens RJ,Gascoyne RD,Cogné M,Tarte K,Wende

更新日期：2016-10-06 00:00:00

abstract：:Ubiquitin chains serve as a recognition motif for the proteasome, a multisubunit protease, which degrades its substrates into polypeptides while releasing ubiquitin for reuse. Yeast proteasomes contain two deubiquitinating enzymes, Ubp6 and Rpn11. Rpn11 promotes protein breakdown through its degradation-coupled activi...

journal_title：Cell

authors： Hanna J,Hathaway NA,Tone Y,Crosas B,Elsasser S,Kirkpatrick DS,Leggett DS,Gygi SP,King RW,Finley D

更新日期：2006-10-06 00:00:00

abstract：:Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrop...

journal_title：Cell

authors： Owen SF,Berke JD,Kreitzer AC

更新日期：2018-02-08 00:00:00