Abstract:
:AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/GluR2 receptors are added to synapses during plasticity; this requires interactions between GluR1 and group I PDZ domain proteins. In contrast, GluR2/GluR3 receptors replace existing synaptic receptors continuously; this occurs only at synapses that already have AMPA-Rs and requires interactions by GluR2 with NSF and group II PDZ domain proteins. The combination of regulated addition and continuous replacement of synaptic receptors can stabilize long-term changes in synaptic efficacy and may serve as a general model for how surface receptor number is established and maintained.
journal_name
Celljournal_title
Cellauthors
Shi S,Hayashi Y,Esteban JA,Malinow Rdoi
10.1016/s0092-8674(01)00321-xsubject
Has Abstractpub_date
2001-05-04 00:00:00pages
331-43issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(01)00321-Xjournal_volume
105pub_type
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