Characterization of Op3, a lysis-defective mutant of bacteriophage f2.

abstract：:During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. H...

journal_title：Cell

authors： Linneweber GA,Jacobson J,Busch KE,Hudry B,Christov CP,Dormann D,Yuan M,Otani T,Knust E,de Bono M,Miguel-Aliaga I

更新日期：2014-01-16 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) is a cell cycle and growth regulated protein required for replication of SV40 DNA in vitro. Its function was investigated by comparison of the replication products synthesized in its presence or absence. In the completely reconstituted replication system that contains PCNA, DN...

journal_title：Cell

authors： Prelich G,Stillman B

更新日期：1988-04-08 00:00:00

abstract：:The mitochondrial unfolded protein response (UPRmt) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organ...

journal_title：Cell

authors： Zhang Q,Wu X,Chen P,Liu L,Xin N,Tian Y,Dillin A

更新日期：2018-08-09 00:00:00

abstract：:Chimeric histocompatibility genes encoding the amino-terminal (beta 1) domain of the class II Ak beta polypeptide and the carboxy-terminal (C2, transmembrane, and intracytoplasmic) domains of either the class I H-2Ld or H-2Dd molecules were stably introduced into mouse L cells. Although both were transcribed, only 5' ...

journal_title：Cell

authors： McCluskey J,Germain RN,Margulies DH

更新日期：1985-02-01 00:00:00

abstract：:We have examined the molecular organization of a region of mouse chromosome 17 that allows homologous recombination between wild-type and t haplotype chromosomes across a large inversion. We have used a combination of genetic mapping of restriction fragment length polymorphisms, molecular characterization of cloned re...

journal_title：Cell

authors： Herrmann BG,Barlow DP,Lehrach H

更新日期：1987-03-13 00:00:00

abstract：:In addition to xeroderma pigmentosum, mutations in the human XPG gene cause early onset Cockayne syndrome (CS). Here, we provide evidence for the involvement of RAD2, the S. cerevisiae counterpart of XPG, in promoting efficient RNA polymerase II transcription. Inactivation of RAD26, the S. cerevisiae counterpart of th...

journal_title：Cell

authors： Lee SK,Yu SL,Prakash L,Prakash S

更新日期：2002-06-28 00:00:00

abstract：:Muscle cell cultures from Drosophila melanogaster were obtained by plating dissociated gastrula stage embryo cells on protamine-treated culture dishes. They myogenic cells in these cultures fuse to form multinucleated pulsating cells by 15 hr after plating. An analysis of protein synthesis during myogenesis in these c...

journal_title：Cell

authors： Storti RV,Horovitch SJ,Scott MP,Rich A,Pardue ML

更新日期：1978-04-01 00:00:00

abstract：:Mouse plasmacytoma (MOPC) 460 cells contain two chromatographic forms of RNA polymerase III (IIIA and IIIB) in addition to the major class I and II RNA polymerases. Nuclei isolated from these cells actively synthesize RNA. Among the discrete transcription products observed are the 5S and 4.5S RNAs and additional low m...

journal_title：Cell

authors： Sklar VE,Roeder RG

更新日期：1977-03-01 00:00:00

abstract：:The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which unde...

journal_title：Cell

authors： Karavani E,Zuk O,Zeevi D,Barzilai N,Stefanis NC,Hatzimanolis A,Smyrnis N,Avramopoulos D,Kruglyak L,Atzmon G,Lam M,Lencz T,Carmi S

更新日期：2019-11-27 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 controls progression to S phase and mitosis by stabilizing key APC/C ubiquitination substrates, including cyclin A. Examining Emi1 binding proteins, we identified the Evi5 oncogene as a regulator of Emi1 accumulation. Evi5 antagonizes SCF(betaTrCP)-depend...

journal_title：Cell

authors： Eldridge AG,Loktev AV,Hansen DV,Verschuren EW,Reimann JD,Jackson PK

更新日期：2006-01-27 00:00:00

abstract：:The v-erbB gene product of avian erythroblastosis virus (AEV) has extensive homology with the receptor for epidermal growth factor (EGF). We report here that chicken embryo fibroblasts (CEF) transformed by AEV show enhanced tyrosine phosphorylation of a number of cellular polypeptides, including the 36 kd protein, whi...

journal_title：Cell

authors： Gilmore T,DeClue JE,Martin GS

更新日期：1985-03-01 00:00:00

abstract：:Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrop...

journal_title：Cell

authors： Owen SF,Berke JD,Kreitzer AC

更新日期：2018-02-08 00:00:00

abstract：:A hybrid beta-galactosidase molecule containing a substantial portion of the amino-terminal sequence of the maltose-binding protein is inserted in the cytoplasmic membrane of E. coli; in this location, the protein has very low enzymatic activity. The strain producing it is, therefore, Lac-. Selection for derivatives o...

journal_title：Cell

authors： Oliver DB,Beckwith J

更新日期：1981-09-01 00:00:00

abstract：:3.18 kb fragments of X. laevis DNA coding for tRNA 1 met have been inserted into a lambda vector via Hind III termini and cloned in E. coli. The organization of one cloned fragment has been analyzed by restriction endonuclease digestion and RNA-DNA hybridization. From the distribution of sites for three enzymes, this ...

journal_title：Cell

authors： Clarkson SG,Kurer V,Smith HO

更新日期：1978-07-01 00:00:00

abstract：:Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and p...

journal_title：Cell

authors： Tejeda HA,Bonci A

更新日期：2014-06-19 00:00:00

abstract：:White adipose tissue (WAT) serves as the primary energy depot in the body by storing fat. During development, fat cell precursors (i.e., preadipocytes) undergo a hypertrophic response as they mature into lipid-laden adipocytes. However, the mechanisms that regulate adipocyte size and mass remain undefined. Herein, we ...

journal_title：Cell

authors： Chun TH,Hotary KB,Sabeh F,Saltiel AR,Allen ED,Weiss SJ

更新日期：2006-05-05 00:00:00

abstract：:The transport kinetics of the influenza virus hemagglutinin from its site of synthesis to the apical plasma membrane of Madin-Darby canine kidney cells, a polarized epithelial cell line, were studied by a sensitive tryptic assay. Hemagglutinin acquired terminal sugars, as judged by sensitivity to endo-beta-N-acetylglu...

journal_title：Cell

authors： Matlin KS,Simons K

更新日期：1983-08-01 00:00:00

abstract：:The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated switch from Myc-Max to Mad-Max heterocomplexes seem to repress genes normally activated by Myc-Max. We have identified two related mammalian cDNAs that enc...

journal_title：Cell

authors： Ayer DE,Lawrence QA,Eisenman RN

更新日期：1995-03-10 00:00:00

abstract：:To determine whether phylogenetically conservative H-Y antigen plays any part in gonadal differentiation among the nonmammalian vertebrates, we studied expression and binding of H-Y in the frog, Xenopus laevis. Soluble H-Y obtained from mouse testis and soluble H-W from chicken ovary bound specifically to cells of the...

journal_title：Cell

authors： Wachtel SS,Bresler PA,Koide SS

更新日期：1980-07-01 00:00:00

abstract：:Replicative intermediates of SV40 were isolated, digested with the restriction endonuclease Bgl I and examined by electron microscopy. Over 98% of the replicative intermediates isolated following infection with wild-type virions at 33 degrees, 37 degrees or 40 degrees C or with tsA209 at 33 degrees C had initiated rep...

journal_title：Cell

authors： Martin RG,Setlow VP

更新日期：1980-06-01 00:00:00

abstract：:The E. coli replication fork synthesizes DNA at the rate of nearly 1000 nt/s. We show here that an interaction between the tau subunit of the replicative polymerase (the DNA polymerase III holoenzyme) and the replication fork DNA helicase (DnaB) is required to mediate this high rate of replication fork movement. In th...

journal_title：Cell

authors： Kim S,Dallmann HG,McHenry CS,Marians KJ

更新日期：1996-02-23 00:00:00

abstract：:Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...

journal_title：Cell

authors： Klein R

更新日期：2010-10-01 00:00:00

abstract：:Elucidating the global and local rules that govern genome-wide, hierarchical chromatin architecture remains a critical challenge. Current high-throughput chromosome conformation capture (Hi-C) technologies have identified large-scale chromatin structural motifs, such as topologically associating domains and looping. H...

journal_title：Cell

authors： Ohno M,Ando T,Priest DG,Kumar V,Yoshida Y,Taniguchi Y

更新日期：2019-01-24 00:00:00

abstract：:Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regula...

journal_title：Cell

authors： Wrana JL

更新日期：2009-01-09 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (RB) binds several cellular proteins involved in cell cycle progression. Using the yeast two-hybrid system, we found that RB bound specifically to the protein BRG1. BRG1 shares extensive sequence similarity to Drosophila brahma, an activator of homeotic gene expression, and ...

journal_title：Cell

authors： Dunaief JL,Strober BE,Guha S,Khavari PA,Alin K,Luban J,Begemann M,Crabtree GR,Goff SP

更新日期：1994-10-07 00:00:00

abstract：:Toll-like receptors (TLRs) are membrane-bound sensors that detect and respond to microbial infection. Two studies in Cell, one in this issue, reveal how TLRs recognize their ligands. Kim et al. (2007) recently reported the structure of TLR4 bound to the accessory protein MD-2 and its antagonist, the drug eritoran. In ...

journal_title：Cell

authors： Brodsky I,Medzhitov R

更新日期：2007-09-21 00:00:00

abstract：:The expression of MHC class II genes is tightly regulated. One form of congenital severe combined immunodeficiency (SCID) is characterized by a regulatory defect that precludes expression of HLA class II genes. B lymphocyte cell lines from such SCID patients provide a tool for identifying putative regulatory proteins ...

journal_title：Cell

authors： Reith W,Satola S,Sanchez CH,Amaldi I,Lisowska-Grospierre B,Griscelli C,Hadam MR,Mach B

更新日期：1988-06-17 00:00:00

abstract：:The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic stress; however, the p53 response can only be executed if its interaction with its inhibitor Mdm2 is abolished. There have been conflicting reports on the question of whether p53 posttranslational modifications, such as phosphory...

journal_title：Cell

authors： Tang Y,Zhao W,Chen Y,Zhao Y,Gu W

更新日期：2008-05-16 00:00:00

abstract：:Lymphocyte migration is essential for adaptive immune surveillance. However, our current understanding of this process is rudimentary, because most human studies have been restricted to immunological analyses of blood and various tissues. To address this knowledge gap, we used an integrated approach to characterize ti...

journal_title：Cell

authors： Buggert M,Vella LA,Nguyen S,Wu VH,Chen Z,Sekine T,Perez-Potti A,Maldini CR,Manne S,Darko S,Ransier A,Kuri-Cervantes L,Japp AS,Brody IB,Ivarsson MA,Gorin JB,Rivera-Ballesteros O,Hertwig L,Antel JP,Johnson ME,Okoye

更新日期：2020-12-23 00:00:00

abstract：:Genes are packaged into nucleosomal arrays, each nucleosome typically having two copies of histones H2A, H2B, H3, and H4. Histones have distinct posttranslational modifications, variant isoforms, and dynamics. Whether each histone copy within a nucleosome has distinct properties, particularly in relation to the direct...

journal_title：Cell

authors： Rhee HS,Bataille AR,Zhang L,Pugh BF

更新日期：2014-12-04 00:00:00