Abstract：
:Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Although inducers of inflammation may be generated in a disease-specific manner, there is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators. A major unanswered question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease.
journal_name
Celljournal_title
Cellauthors
Glass CK,Saijo K,Winner B,Marchetto MC,Gage FHdoi
10.1016/j.cell.2010.02.016subject
Has Abstractpub_date
2010-03-19 00:00:00pages
918-34issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(10)00168-6journal_volume
140pub_type
杂志文章,评审相关文献
CELL文献大全abstract：:Transcriptional pausing by multisubunit RNA polymerases (RNAPs) is a key mechanism for regulating gene expression in both prokaryotes and eukaryotes and is a prerequisite for transcription termination. Pausing and termination states are thought to arise through a common, elemental pause state that is inhibitory for nu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.12.020
更新日期：2013-01-31 00:00:00
abstract：:The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90081-8
更新日期：1978-09-01 00:00:00
abstract：:The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4+ T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, we found...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.10.001
更新日期：2020-11-25 00:00:00
abstract：:In extracts from rat and calf uterus, the steroid hormone 17 beta-estradiol stimulates the binding of its specific receptor protein to DNA. This interaction appears to be of low affinity (half of the estradiol-activated, 5S receptor bound at 300-400 mug/ml DNA) and nonspecific with respect to DNA base sequence. No bin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90150-6
更新日期：1975-04-01 00:00:00
abstract：:The human multidrug resistance P-glycoprotein is an active transporter that pumps cytotoxic drugs out of cells. Expression of P-glycoprotein is also associated with a volume-activated chloride channel. Here we address the relationship between these two functions. Drug transport requires ATP hydrolysis while, in contra...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90263-c
更新日期：1992-10-02 00:00:00
abstract：:We have isolated a population of vesicular carriers involved in the transport (transcytosis) of proteins from the basolateral to the apical plasma membrane of hepatocytes. The obtained fraction was enriched in compartments containing known transcytosed proteins and depleted in elements of the secretory pathway, Golgi ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90210-p
更新日期：1991-01-11 00:00:00
abstract：:Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) family. After duplic...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.09.003
更新日期：2014-09-25 00:00:00
abstract：:The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance, mutations in the negative regulator KEAP1. While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant activ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.08.051
更新日期：2017-10-19 00:00:00
abstract：:Who are science journalists, and how can journalists and research scientists work together to improve science communication? ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.10.051
更新日期：2016-11-17 00:00:00
abstract：:The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81771-7
更新日期：1998-10-30 00:00:00
abstract：:Endoplasmic reticulum (ER) membrane contact sites (MCSs) mark positions where endosomes undergo fission for cargo sorting. To define the role of ER at this unique MCS, we targeted a promiscuous biotin ligase to cargo-sorting domains on endosome buds. This strategy identified the ER membrane protein TMCC1, a member of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.08.030
更新日期：2018-09-20 00:00:00
abstract：:Mice deficient for interleukin-2 develop normally during the first 3-4 weeks of age. However, later on they become severely compromised, and about 50% of the animals die between 4 and 9 weeks after birth. Of the remaining mice, 100% develop an inflammatory bowel disease with striking clinical and histological similari...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)80067-o
更新日期：1993-10-22 00:00:00
abstract：:Multipotent cardiac progenitor cells are found in the fetal and adult heart of many mammalian species including humans and form as intermediates during the differentiation of embryonic stem cells. Despite similar biological properties, the molecular identities of these different cardiac progenitor cell populations app...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.02.002
更新日期：2008-02-22 00:00:00
abstract：:Polarity in mammalian cells emerges from the assembly of signaling molecules into extensive biochemical interaction networks. Despite their complexity, bacterial pathogens have evolved parsimonious mechanisms to hijack these systems. Here, we develop a tractable experimental and theoretical model to uncover fundamenta...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.11.063
更新日期：2012-02-17 00:00:00
abstract：:In this report, we describe the isolation, sequence, and initial characterization of the cDNA for the muscle-specific regulatory factor skeletal myogenin. Transfection of myogenin into the mesenchymal cell line C3H10T1/2 produces cells expressing muscle-specific markers. Myogenin is absent in undifferentiated cells, p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90583-7
更新日期：1989-02-24 00:00:00
abstract：:Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during agi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.03.032
更新日期：2015-05-07 00:00:00
abstract：:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.08.005
更新日期：2015-08-27 00:00:00
abstract：:The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum re...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80469-9
更新日期：1997-12-12 00:00:00
abstract：:Membrane subdomains have been implicated in T cell signaling, although their properties and mechanisms of formation remain controversial. Here, we have used single-molecule and scanning confocal imaging to characterize the behavior of GFP-tagged signaling proteins in Jurkat T cells. We show that the coreceptor CD2, th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.04.009
更新日期：2005-06-17 00:00:00
abstract：:We have investigated RNA recombination among poliovirus genomes by analyzing both intratypic and intertypic recombinant crosses involving the same defined genetic markers. Sequence analysis of the recombinant junctions of 13 nonsibling intertypic recombinants showed that intertypic RNA recombination is not site-specif...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90600-8
更新日期：1986-11-07 00:00:00
abstract：:torso encodes a receptor tyrosine kinase (torso) required for anterior and posterior terminal development of the Drosophila embryo. Injecting eggs with in vitro synthesized torso mRNAs revealed that torso activation is governed by an extracellular molecule, presumably the torso ligand, produced at terminal regions of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90394-r
更新日期：1992-12-11 00:00:00
abstract：:Newly synthesized proteins are believed to move from the endoplasmic reticulum (ER) to the Golgi by bulk flow, and sorting is assumed to occur exclusively in the trans-Golgi network (TGN). Using quantitative immunoelectron microscopy, we demonstrate that vesicular stomatitis virus glycoprotein (VSV-G) is sorted from r...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90359-x
更新日期：1994-03-11 00:00:00
abstract：:The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90424-o
更新日期：1993-07-30 00:00:00
abstract：:The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro. Remarkably, the site of p53 that is acetylated by its coactivator, p300, resides in ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80521-8
更新日期：1997-08-22 00:00:00
abstract：:The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and facilitating their hybridization with cognate preedited mRNAs. To understand the mechanism by which this complex pe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.06.047
更新日期：2006-08-25 00:00:00
abstract：:Clinical trials are key to translating scientific advances into progress in cancer research and care. Confronted by developments in basic science, the landscape of clinical cancer research is rapidly evolving. Here, we review recent changes in clinical trials' design and conduct, and we forecast future directions towa...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.01.027
更新日期：2017-02-09 00:00:00
abstract：:Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). However, the phosphorylation events critical for tau toxicity and mechanisms regulating these events are largely unknown. Here we show that Drosophila PAR-1 kinase initiates t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(04)00170-9
更新日期：2004-03-05 00:00:00
abstract：:Congenital scoliosis, a lateral curvature of the spine caused by vertebral defects, occurs in approximately 1 in 1,000 live births. Here we demonstrate that haploinsufficiency of Notch signaling pathway genes in humans can cause this congenital abnormality. We also show that in a mouse model, the combination of this g...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.02.054
更新日期：2012-04-13 00:00:00
abstract：:Activation of the cyclin-dependent kinases to promote cell cycle progression requires their association with cyclins as well as phosphorylation of a threonine (residue 161 in human p34cdc2). This phosphorylation is carried out by CAK, the Cdk-activating kinase. We have purified and cloned CAK from S. cerevisiae. Unlik...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80129-4
更新日期：1996-08-23 00:00:00
abstract：:We previously demonstrated that pseudogenes complementary to the small nuclear RNAs U1, U2 and U3 are dispersed and abundant in the human genome. Here we report that three pseudogenes (U1.101, U2.13 and U3.5) are flanked by perfect short direct repeats of 16 to 19 base pairs. In all three pseudogenes. the upstream dir...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90028-3
更新日期：1981-10-01 00:00:00
