Abstract：
:The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity in their respective organisms. This activity does not depend on endogenous gene function. Our results indicate that the intracellular domains of Lin-12 and Notch have intrinsic activity and that the principal role of the extracellular domains in the intact proteins is to regulate this activity. Our results also suggest that equivalent truncated forms of lin-12/Notch family members in vertebrates, including known oncogenes, are similarly active.
journal_name
Celljournal_title
Cellauthors
Struhl G,Fitzgerald K,Greenwald Idoi
10.1016/0092-8674(93)90424-osubject
Has Abstractpub_date
1993-07-30 00:00:00pages
331-45issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(93)90424-Ojournal_volume
74pub_type
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