Abstract：
:In Xenopus development, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylation. CPEB and maskin, two factors that control polyadenylation-induced translation are present on the mitotic apparatus of animal pole blastomeres in embryos. Cyclin B1 protein and mRNA, whose translation is regulated by polyadenylation, are colocalized with CPEB and maskin. CPEB interacts with microtubules and is involved in the localization of cyclin B1 mRNA to the mitotic apparatus. Agents that disrupt polyadenylation-induced translation inhibit cell division and promote spindle and centrosome defects in injected embryos. Two of these agents inhibit the synthesis of cyclin B1 protein and one, which has little effect on this process, disrupts the localization of cyclin B1 mRNA and protein. These data suggest that CPEB-regulated mRNA translation is important for the integrity of the mitotic apparatus and for cell division.
journal_name
Celljournal_title
Cellauthors
Groisman I,Huang YS,Mendez R,Cao Q,Theurkauf W,Richter JDdoi
10.1016/s0092-8674(00)00135-5subject
Has Abstractpub_date
2000-10-27 00:00:00pages
435-47issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(00)00135-5journal_volume
103pub_type
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