Abstract：
:Meiotic cohesin serves in sister chromatid linkage and DNA repair until its subunit Rec8 is cleaved by separase. Separase is activated when its inhibitor, securin, is polyubiquitinated by the Cdc20 regulated anaphase-promoting complex (APC(Cdc20)) and consequently degraded. Differently regulated APCs (APC(Cdh1), APC(Ama1)) have not been implicated in securin degradation at meiosis I. We show that Mnd2, a factor known to associate with APC components, prevents premature securin degradation in meiosis by APC(Ama1). mnd2Delta cells lack linear chromosome axes and exhibit precocious sister chromatid separation, but deletion of AMA1 suppresses these defects. Besides securin, Sgo1, a protein essential for protection of centromeric cohesion during anaphase I, is also destabilized in mnd2delta cells. Mnd2's disappearance prior to anaphase II may activate APC(Ama1). Human oocytes may spend many years in meiotic prophase before maturation. Inhibitors of meiotic APC variants could prevent loss of chiasmata also in these cells, thereby guarding against aberrant chromosome segregation.
journal_name
Celljournal_title
Cellauthors
Penkner AM,Prinz S,Ferscha S,Klein Fdoi
10.1016/j.cell.2005.01.017subject
Has Abstractpub_date
2005-03-25 00:00:00pages
789-801issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00091-7journal_volume
120pub_type
杂志文章相关文献
CELL文献大全abstract：:The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2011.02.013
更新日期：2011-03-04 00:00:00
abstract：:Muscle cell cultures from Drosophila melanogaster were obtained by plating dissociated gastrula stage embryo cells on protamine-treated culture dishes. They myogenic cells in these cultures fuse to form multinucleated pulsating cells by 15 hr after plating. An analysis of protein synthesis during myogenesis in these c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90210-6
更新日期：1978-04-01 00:00:00
abstract：:5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB; 75 muM) inhibited only 60-75% of nuclear heterogeneous RNA (hnRNA) synthesis in HeLa cells, while the appearance of labeled cytoplasmic poly(A)-containing messenger RNA (mRNA) was reduced by approximately 95%. DRB-sensitive and resistant transcripts spanned the e...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90092-1
更新日期：1976-11-01 00:00:00
abstract：:The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infect...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2021.01.007
更新日期：2021-01-12 00:00:00
abstract：:Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.05.049
更新日期：2014-07-31 00:00:00
abstract：:Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs and direct posttranscriptional gene regulation. A final posttranscriptional step in gene expression is the turnover of the mRNP, which involves degradation of the mRNA and recycling of assoc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.11.043
更新日期：2010-12-10 00:00:00
abstract：:The ephrin/Eph system plays a central role in neuronal circuit formation; however, its downstream effectors are poorly understood. Here we show that alpha-chimerin Rac GTPase-activating protein mediates ephrinB3/EphA4 forward signaling. We discovered a spontaneous mouse mutation, miffy (mfy), which results in a rabbit...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.07.022
更新日期：2007-08-24 00:00:00
abstract：:The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcription...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2006.01.002
更新日期：2006-01-27 00:00:00
abstract：:During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2005.10.015
更新日期：2005-11-04 00:00:00
abstract：:Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tiss...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.12.021
更新日期：2015-01-15 00:00:00
abstract：:Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expressio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.03.035
更新日期：2018-04-05 00:00:00
abstract：:Minimal hammerhead ribozymes have been characterized extensively by static and time-resolved crystallography as well as numerous biochemical analyses, leading to mutually contradictory mechanistic explanations for catalysis. We present the 2.2 A resolution crystal structure of a full-length Schistosoma mansoni hammerh...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.06.036
更新日期：2006-07-28 00:00:00
abstract：:Epidermal growth factor (EGF) regulates cell proliferation and differentiation by binding to the EGF receptor (EGFR) extracellular region, comprising domains I-IV, with the resultant dimerization of the receptor tyrosine kinase. In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00963-7
更新日期：2002-09-20 00:00:00
abstract：:Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Despite the importance of these events, current understanding of their gen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.07.048
更新日期：2011-09-30 00:00:00
abstract：:Different hematopoietic cells produce minute amounts of beta-related interferon (IFN) following induction of differentiation by chemical or natural inducers. The endogenous IFN binds to type I cell surface receptors and modulates gene expression in the producer cells. We show that self-induction of two members of the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90857-3
更新日期：1986-07-04 00:00:00
abstract：:Malignancy can be suppressed by the immune system in a process termed immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous cancers and the composition of participating cell types remains obscure. Here, we show that cell transformation triggers a tissue-resident lymphocyte response in on...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.01.002
更新日期：2016-01-28 00:00:00
abstract：:The somatic 5S DNA from X. borealis (Xbs 5S DNA) and X. laevis (Xis 5S DNA) and a minor oocyte-specific 5S DNA from X. laevis (Xit 5S DNA) have been purified, and individual repeating units have been cloned and sequenced. The two somatic 5S DNAs differ from the major oocyte 5S DNAs in having GC-rich spacers, homogeneo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90241-x
更新日期：1980-05-01 00:00:00
abstract：:Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or irri...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.12.002
更新日期：2020-01-09 00:00:00
abstract：:Nociceptin and its receptor are widely distributed throughout the brain in regions associated with reward behavior, yet how and when they act is unknown. Here, we dissected the role of a nociceptin peptide circuit in reward seeking. We generated a prepronociceptin (Pnoc)-Cre mouse line that revealed a unique subpopula...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.06.034
更新日期：2019-07-25 00:00:00
abstract：:Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90479-4
更新日期：1995-09-08 00:00:00
abstract：:Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/0092-8674(95)90326-7
更新日期：1995-04-21 00:00:00
abstract：:The globin and immunoglobulin multigene families have been used to study the effect of chromosomal organization on the time of gene replication. Some of the genes are late-replicating, providing the first identification of late-replicating sequences that are not highly repetitive. One is a member of the mouse alpha-gl...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90349-0
更新日期：1984-03-01 00:00:00
abstract：:We used the interaction trap, a yeast genetic selection for interacting proteins, to isolate human cyclin-dependent kinase interactor 1 (Cdi1). In yeast, Cdi1 interacts with cyclin-dependent kinases, including human Cdc2, Cdk2, and Cdk3, but not with Ckd4. In HeLa cells, Cdi1 is expressed at the G1 to S transition, an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90498-f
更新日期：1993-11-19 00:00:00
abstract：:The trk tyrosine kinase proto-oncogene product gp140prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high affinity NGF binding an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90441-z
更新日期：1991-09-06 00:00:00
abstract：:Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they represent secondary messengers affecting numerous responses of the prokaryotic cell, whereas in the latter, they act as agonists of the inn...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.08.014
更新日期：2013-08-29 00:00:00
abstract：:The v-erbB gene product of avian erythroblastosis virus (AEV) has extensive homology with the receptor for epidermal growth factor (EGF). We report here that chicken embryo fibroblasts (CEF) transformed by AEV show enhanced tyrosine phosphorylation of a number of cellular polypeptides, including the 36 kd protein, whi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90209-0
更新日期：1985-03-01 00:00:00
abstract：:Every day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions; however, the underlying neuron...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.08.035
更新日期：2020-10-01 00:00:00
abstract：:The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.10.053
更新日期：2009-01-09 00:00:00
abstract：:We have adopted Drosophila tissue culture cells as a host system for studying the structure and function of mammalian transcription factors. These cells provide an Sp1-deficient background and have been used in a complementation assay to identify functional domains of human transcription factor Sp1. The SV40 early pro...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90144-4
更新日期：1988-12-02 00:00:00
abstract：:Vascular permeability is frequently associated with inflammation and is triggered by a cohort of secreted permeability factors such as vascular endothelial growth factor (VEGF). Here, we show that the physiological vascular permeability that precedes implantation is directly controlled by progesterone receptor (PR) an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.025
更新日期：2014-01-30 00:00:00
