Abstract:
:Academic travel has a substantial carbon footprint. The ongoing pandemic has propelled the development and adoption of technologies for online delivery of seminars and remote attendance at scientific conferences. This should not lead to the complete elimination of in-person events, but the scientific community must seize the opportunity to permanently change its modus operandi and reduce the impact of its activities on the environment.
journal_name
Celljournal_title
Cellauthors
Geitmann Adoi
10.1016/j.cell.2020.07.026subject
Has Abstractpub_date
2020-08-20 00:00:00pages
790-793issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(20)30934-Xjournal_volume
182pub_type
杂志文章相关文献
CELL文献大全abstract::We have sequenced HFL1 from D. melanogaster, the only cloned hobo element shown to have transposase activity. The 2959 bp HFL1 sequence predicts a 2.0 kb open reading frame (ORF1) with substantial amino acid similarity to the transposases of Activator (Ac) from maize (Zea mays) and Tam3 from snapdragon (Antirrhinum ma...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90010-6
更新日期:1991-08-09 00:00:00
abstract::We have reproduced the posttranslational mode of protein translocation across the endoplasmic reticulum membrane with reconstituted proteoliposomes containing a purified complex of seven yeast proteins. This Sec complex includes a heterotrimeric Sec61p complex, homologous to that in mammals, as well as all other membr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90077-2
更新日期:1995-05-19 00:00:00
abstract::Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.02.017
更新日期:2007-03-23 00:00:00
abstract::We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90092-1
更新日期:1981-06-01 00:00:00
abstract::Certain tRNAs in S. cerevisiae (tRNATyr and tRNAPhe) arise via precursor molecules which are mature at the 5' and 3' termini but contain intervening sequences adjacent to the anticodon (Knapp et al., 1978; O'Farrell et al., 1978). In addition to these molecules, precursors to several other tRNAs accumulate in a temper...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90349-0
更新日期:1979-09-01 00:00:00
abstract::We have identified a yeast protein that binds specifically to the ARS consensus sequence. By two-step chromatography we have purified the factor to apparent homogeneity as a single polypeptide of 67 kd. The purified ARS consensus-binding protein (ACBP) recognizes the ARS consensus of the four genomic ARS elements test...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90319-t
更新日期:1991-03-08 00:00:00
abstract::MicroRNAs are small endogenous noncoding RNAs involved in posttranscriptional gene regulation. During microRNA biogenesis, Drosha and Dicer process the primary transcript (pri-miRNA) through a precursor hairpin (pre-miRNA) to the mature miRNA. The miRNA is incorporated into the RNA-Induced Silencing Complex (RISC) wit...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.10.032
更新日期:2007-12-14 00:00:00
abstract::Methylation of deoxycytidine incorporated by DNA excision-repair was studied in human diploid fibroblasts following damage with ultraviolet radiation, N-methyl-N-nitrosourea, or N-acetoxy-2-acetylaminofluorene. In confluent, nondividing cells, methylation in repair patches induced by all three agents is slow and incom...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90248-3
更新日期:1982-09-01 00:00:00
abstract::The tra-1 gene plays a central role in C. elegans sex determination. XX animals develop as hermaphrodites when tra-1 is active and as males when it is not. By analyzing a large number of tra-1 genetic mosaics we have shown that, with the expected exception of vulval induction by the hermaphrodite gonad, tra-1 function...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90415-b
更新日期:1990-12-21 00:00:00
abstract::Rubisco, the key enzyme of CO2 fixation in photosynthesis, is prone to inactivation by inhibitory sugar phosphates. Inhibited Rubisco undergoes conformational repair by the hexameric AAA+ chaperone Rubisco activase (Rca) in a process that is not well understood. Here, we performed a structural and mechanistic analysis...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.09.010
更新日期:2020-10-15 00:00:00
abstract::We have established the DNA sequence of nine yeast mutants that prevent the expression either of the split cytochrome b gene alone (five mutants) or of two split genes, the cytochrome b gene and the cytochrome oxidase subunit I gene (four mutants). All the mutations analyzed are localized in intron 14 of the cob-box g...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90051-4
更新日期:1982-04-01 00:00:00
abstract::We report that the 12,000 dalton domain of fibronectin that interacts with fibroblast cell surfaces also binds specifically to thrombin-inducible, saturable receptors on platelets. Furthermore, we have used chemical cross-linking and monoclonal antibodies to show that the 12,000 dalton domain of fibronectin interacts ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90101-1
更新日期:1985-09-01 00:00:00
abstract::The human invariant chain (I gamma) of class II histocompatibility antigens spans the membrane of the endoplasmic reticulum once. It exposes a small amino-terminal domain on the cytoplasmic side and a carboxy-terminal, glycosylated domain on the exoplasmic side of the membrane. When the exoplasmic domain of I gamma is...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90710-5
更新日期:1986-09-26 00:00:00
abstract::We have identified a novel octamer binding factor (Oct-3) in P19 embryonal carcinoma cells. Oct-3, which recognizes the typical octamer motif (ATTTGCAT) as well as the AT-rich sequence TTAAAATTCA, is present in P19 stem cells but disappears when the cells are induced to differentiate by retinoic acid (RA). Cloned cDNA...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90597-8
更新日期:1990-02-09 00:00:00
abstract::We describe here a bizarre organization of the single large subunit (LSU) and small subunit (SSU) rRNA genes in the mitochondrial DNA of Chlamydomonas reinhardtii. Each gene is discontinuous, with gene pieces encoding specific rRNA domains ("modules") interspersed with one another and with intact protein coding and tR...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90026-8
更新日期:1988-11-04 00:00:00
abstract::Maintenance of a constant cell volume in response to extracellular or intracellular osmotic changes is critical for cellular homeostasis. Activation of a ubiquitous volume-regulated anion channel (VRAC) plays a key role in this process; however, its molecular identity in vertebrates remains unknown. Here, we used a ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.024
更新日期:2014-04-10 00:00:00
abstract::Dimerization-driven activation of the intracellular kinase domains of the epidermal growth factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways regulating proliferation, migration, and differentiation. Inactive EGFR can exist as both monomers and dimers, suggesting that the mechanis...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.12.030
更新日期:2013-01-31 00:00:00
abstract::Nucleosome assembly following DNA replication and gene transcription is important to maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly. However, it is unknown how H3-H4 is transfe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.10.014
更新日期:2013-11-07 00:00:00
abstract::The alpha IIb beta 3 integrin binds Arg-Gly-Asp-containing (RGD-containing) ligands in a cation-dependent interaction. A fourteen amino acid sequence, beta 3 (118-131), and an antibody to it, inhibited ligand binding functions of alpha IIb beta 3, and a 1:1 stoichiometric beta 3 (118-131)-RGD complex was detected by m...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90551-7
更新日期:1994-11-18 00:00:00
abstract::Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.11.004
更新日期:2015-12-03 00:00:00
abstract::N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognize...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.014
更新日期:2015-06-04 00:00:00
abstract::During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. H...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.12.008
更新日期:2014-01-16 00:00:00
abstract::Mammalian cells express a spectrum of tubulin isotypes whose relationship to the diversity of microtubule function is unknown. To examine whether different isotypes are segregated into functionally distinct microtubules, we generated immune sera capable of discriminating among the various naturally occurring beta-tubu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90456-9
更新日期:1987-05-22 00:00:00
abstract::A novel trimolecular mechanism of microbial attachment to mammalian host cells was characterized for the obligate intracellular pathogen Chlamydia trachomatis. Using purified glycosaminoglycans (GAGs) and specific GAG lyases, we demonstrated that a heparan sulfate-like GAG present on the surface of chlamydia organisms...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90296-o
更新日期:1992-05-29 00:00:00
abstract::Ocean microbial communities strongly influence the biogeochemistry, food webs, and climate of our planet. Despite recent advances in understanding their taxonomic and genomic compositions, little is known about how their transcriptomes vary globally. Here, we present a dataset of 187 metatranscriptomes and 370 metagen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.10.014
更新日期:2019-11-14 00:00:00
abstract::The phenotype of the autosomal recessive mutation scat includes severe intermittent bleeding, depletion of platelets, and circulating anti-platelet antibodies. In this study, we have mapped the scat mutation to mouse chromosome 8 and shown that the immune component is a secondary consequence of the gene defect. Surpri...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90301-6
更新日期:1993-07-16 00:00:00
abstract::Induction of senescence permanently restricts cellular proliferation after oncogenic stimulation thereby acting as a potent barrier to tumor development. The relevant effector proteins may therefore be fundamental to cancer development. A recent study identified IGFBP7 as a secreted factor mediating melanocyte senesce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.04.021
更新日期:2010-05-14 00:00:00
abstract::Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increase in intracellular ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.03.029
更新日期:2015-04-23 00:00:00
abstract::We describe a monoclonal antibody directed against a neuron-specific mitochondrial protein from rat brain. On protein blots the antibody recognizes a single polypeptide of apparent molecular weight of 23,000. By solid-phase immunoassay the antigen was detected in nonneural tissues. Within neurons, the antibody stains ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90343-9
更新日期:1982-02-01 00:00:00
abstract::Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.11.020
更新日期:2021-01-07 00:00:00