Abstract：
:Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow. We identify a population of CD62L(LO) CXCR4(HI) neutrophils that have "aged" in the circulation and are eliminated at the end of the resting period in mice. Aged neutrophils infiltrate the bone marrow and promote reductions in the size and function of the hematopoietic niche. Modulation of the niche depends on macrophages and activation of cholesterol-sensing nuclear receptors and is essential for the rhythmic egress of hematopoietic progenitors into the circulation. Our results unveil a process that synchronizes immune and hematopoietic rhythms and expand the ascribed functions of neutrophils beyond inflammation. PAPERFLICK:
journal_name
Celljournal_title
Cellauthors
Casanova-Acebes M,Pitaval C,Weiss LA,Nombela-Arrieta C,Chèvre R,A-González N,Kunisaki Y,Zhang D,van Rooijen N,Silberstein LE,Weber C,Nagasawa T,Frenette PS,Castrillo A,Hidalgo Adoi
10.1016/j.cell.2013.04.040subject
Has Abstractpub_date
2013-05-23 00:00:00pages
1025-35issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(13)00516-3journal_volume
153pub_type
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