Abstract：
:Living organisms sense their physical environment through cellular mechanotransduction, which converts mechanical forces into electrical and biochemical signals. In turn, signal transduction serves a wide variety of functions, from basic cellular processes as diverse as proliferation, differentiation, migration, and apoptosis up to some of the most sophisticated senses, including touch and hearing. Accordingly, defects in mechanosensing potentially lead to diverse diseases and disorders such as hearing loss, cardiomyopathies, muscular dystrophies, chronic pain, and cancer. Here, we review the status of mechanically activated ion channel discovery and discuss current challenges to define their properties and physiological functions.
journal_name
Celljournal_title
Cellauthors
Delmas P,Coste Bdoi
10.1016/j.cell.2013.09.026subject
Has Abstractpub_date
2013-10-10 00:00:00pages
278-84issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01163-Xjournal_volume
155pub_type
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