Lung Cancer: A Wily Genetic Opponent.

abstract：:Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated w...

journal_title：Cell

authors： Imamovic L,Ellabaan MMH,Dantas Machado AM,Citterio L,Wulff T,Molin S,Krogh Johansen H,Sommer MOA

更新日期：2018-01-11 00:00:00

abstract：:The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...

journal_title：Cell

authors： Heindell HC,Liu A,Paddock GV,Studnicka GM,Salser WA

更新日期：1978-09-01 00:00:00

abstract：:The formation of morphogen gradients is essential for tissue patterning. Morphogens are released from producing cells and spread through adjacent tissue; paradoxically, however, many morphogens, including Wingless, associate tightly with the cell membrane. Here, we describe a novel cell biological mechanism that dispe...

journal_title：Cell

authors： Greco V,Hannus M,Eaton S

更新日期：2001-09-07 00:00:00

abstract：:The expression of MHC class II genes is tightly regulated. One form of congenital severe combined immunodeficiency (SCID) is characterized by a regulatory defect that precludes expression of HLA class II genes. B lymphocyte cell lines from such SCID patients provide a tool for identifying putative regulatory proteins ...

journal_title：Cell

authors： Reith W,Satola S,Sanchez CH,Amaldi I,Lisowska-Grospierre B,Griscelli C,Hadam MR,Mach B

更新日期：1988-06-17 00:00:00

abstract：:Members of the E2F transcription factor family (E2F-1-E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs have not been elucidated. Mice were generated that lack E2F-1 and, surprisingly, these mice develop and reproduce no...

journal_title：Cell

authors： Field SJ,Tsai FY,Kuo F,Zubiaga AM,Kaelin WG Jr,Livingston DM,Orkin SH,Greenberg ME

更新日期：1996-05-17 00:00:00

abstract：:Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyalu...

journal_title：Cell

authors： Koopman M,Hetz C,Nollen EAA

更新日期：2019-11-27 00:00:00

abstract：:Defects in the gene encoding the endothelin-B receptor produce aganglionic megacolon and pigmentary disorders in mice and humans. We report that a targeted disruption of the mouse endothelin-3 ligand (EDN3) gene produces a similar recessive phenotype of megacolon and coat color spotting. A natural recessive mutation t...

journal_title：Cell

authors： Baynash AG,Hosoda K,Giaid A,Richardson JA,Emoto N,Hammer RE,Yanagisawa M

更新日期：1994-12-30 00:00:00

abstract：:Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...

journal_title：Cell

authors： Forman BM,Goode E,Chen J,Oro AE,Bradley DJ,Perlmann T,Noonan DJ,Burka LT,McMorris T,Lamph WW,Evans RM,Weinberger C

更新日期：1995-06-02 00:00:00

abstract：:Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself. ...

journal_title：Cell

authors： Vincent JP,Magee T

更新日期：2012-06-22 00:00:00

abstract：:From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a cluster of seven OR genes has been proposed as a trans- and pan-enhance...

journal_title：Cell

authors： Fuss SH,Omura M,Mombaerts P

更新日期：2007-07-27 00:00:00

abstract：:Metazoan evolution involves increasing protein domain complexity, but how this relates to control of biological decisions remains uncertain. The Ras guanine nucleotide exchange factor (RasGEF) Sos1 and its adaptor Grb2 are multidomain proteins that couple fibroblast growth factor (FGF) signaling to activation of the R...

journal_title：Cell

authors： Findlay GM,Smith MJ,Lanner F,Hsiung MS,Gish GD,Petsalaki E,Cockburn K,Kaneko T,Huang H,Bagshaw RD,Ketela T,Tucholska M,Taylor L,Bowtell DD,Moffat J,Ikura M,Li SS,Sidhu SS,Rossant J,Pawson T

更新日期：2013-02-28 00:00:00

abstract：:Large numbers of inbred laboratory rat strains have been developed for a range of complex disease phenotypes. To gain insights into the evolutionary pressures underlying selection for these phenotypes, we sequenced the genomes of 27 rat strains, including 11 models of hypertension, diabetes, and insulin resistance, al...

journal_title：Cell

authors： Atanur SS,Diaz AG,Maratou K,Sarkis A,Rotival M,Game L,Tschannen MR,Kaisaki PJ,Otto GW,Ma MC,Keane TM,Hummel O,Saar K,Chen W,Guryev V,Gopalakrishnan K,Garrett MR,Joe B,Citterio L,Bianchi G,McBride M,Dominiczak A

更新日期：2013-08-01 00:00:00

abstract：:Many biological motor molecules move within cells using stepsizes predictable from their structures. Myosin VI, however, has much larger and more broadly distributed stepsizes than those predicted from its short lever arms. We explain the discrepancy by monitoring Qdots and gold nanoparticles attached to the myosin-VI...

journal_title：Cell

authors： Nishikawa S,Arimoto I,Ikezaki K,Sugawa M,Ueno H,Komori T,Iwane AH,Yanagida T

更新日期：2010-09-17 00:00:00

abstract：:Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies. The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have. ...

journal_title：Cell

authors： Gordon LB,Rothman FG,López-Otín C,Misteli T

更新日期：2014-01-30 00:00:00

abstract：:Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane ...

journal_title：Cell

authors： Malmersjö S,Meyer T

更新日期：2013-06-20 00:00:00

abstract：:Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protei...

journal_title：Cell

authors： Alpatov R,Lesch BJ,Nakamoto-Kinoshita M,Blanco A,Chen S,Stützer A,Armache KJ,Simon MD,Xu C,Ali M,Murn J,Prisic S,Kutateladze TG,Vakoc CR,Min J,Kingston RE,Fischle W,Warren ST,Page DC,Shi Y

更新日期：2014-05-08 00:00:00

abstract：:How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after vi...

journal_title：Cell

authors： Kaech SM,Hemby S,Kersh E,Ahmed R

更新日期：2002-12-13 00:00:00

abstract：:Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic ce...

journal_title：Cell

authors： Ferrell JE Jr,Tsai TY,Yang Q

更新日期：2011-03-18 00:00:00

abstract：:How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition be...

journal_title：Cell

authors： Blackwell TK,Walker AK

更新日期：2008-10-03 00:00:00

abstract：:Toll-like receptors (TLRs) are membrane-bound sensors that detect and respond to microbial infection. Two studies in Cell, one in this issue, reveal how TLRs recognize their ligands. Kim et al. (2007) recently reported the structure of TLR4 bound to the accessory protein MD-2 and its antagonist, the drug eritoran. In ...

journal_title：Cell

authors： Brodsky I,Medzhitov R

更新日期：2007-09-21 00:00:00

abstract：:The spectrin superfamily of proteins plays key roles in assembling the actin cytoskeleton in various cell types, crosslinks actin filaments, and acts as scaffolds for the assembly of large protein complexes involved in structural integrity and mechanosensation, as well as cell signaling. α-actinins in particular are t...

journal_title：Cell

authors： Ribeiro Ede A Jr,Pinotsis N,Ghisleni A,Salmazo A,Konarev PV,Kostan J,Sjöblom B,Schreiner C,Polyansky AA,Gkougkoulia EA,Holt MR,Aachmann FL,Zagrović B,Bordignon E,Pirker KF,Svergun DI,Gautel M,Djinović-Carugo K

更新日期：2014-12-04 00:00:00

abstract：:The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity i...

journal_title：Cell

authors： Yimlamai D,Christodoulou C,Galli GG,Yanger K,Pepe-Mooney B,Gurung B,Shrestha K,Cahan P,Stanger BZ,Camargo FD

更新日期：2014-06-05 00:00:00

abstract：:We have isolated three alleles of a novel Drosophila clock gene, double-time (dbt). Short- (dbtS) and long-period (dbtL) mutants alter both behavioral rhythmicity and molecular oscillations from previously identified clock genes, period and timeless. A third allele, dbtP, causes pupal lethality and eliminates circadia...

journal_title：Cell

authors： Price JL,Blau J,Rothenfluh A,Abodeely M,Kloss B,Young MW

更新日期：1998-07-10 00:00:00

abstract：:This year, the Albert Lasker Basic Medical Research Award will be shared by Michael Sheetz, James Spudich, and Ronald Vale for discoveries concerning the biophysical actions of cytoskeletal motor-protein machines that move cargo within cells, contract muscles, and enable cell motility. ...

journal_title：Cell

authors： Ringe D,Petsko GA

更新日期：2012-09-14 00:00:00

abstract：:Long pyrimidine tracts, purified from Drosophila melanogaster DNA after treatment with formic acid-diphenylamine, were used as template for E. coli RNA polymerase to produce a polynucleotide containing only purines. This polypurine RNA hybridized specifically to D. melanogaster DNA with high efficiency at low Cot valu...

journal_title：Cell

authors： Sederoff R,Lowenstein L

更新日期：1975-06-01 00:00:00

abstract：:The first event in the initiation of eukaryotic DNA replication is the recruitment of the MCM2-7 ATPase, the core of the replicative DNA helicase, to origins. Ticau et al. use single-molecule imaging to reveal how ORC, Cdc6, and Cdt1 cooperate to load MCM2-7 onto DNA, enabling bidirectional replication. ...

journal_title：Cell

authors： Chistol G,Walter JC

更新日期：2015-04-23 00:00:00

abstract：:Novel, approximately 90 bp intervening sequences (IVs) were discovered within the 23S rRNA genes of S. typhimurium and S. arizonae. These non-rRNA sequences are transcribed and then excised during rRNA maturation. The rRNA fragments that result from the excision of the extra sequences are not religated. This results i...

journal_title：Cell

authors： Burgin AB,Parodos K,Lane DJ,Pace NR

更新日期：1990-02-09 00:00:00

abstract：:We determined the nucleotide sequences of all coding regions and a significant part of the flanking regions of the chicken c-src gene, which is a cellular homolog of the v-src gene of Rous sarcoma virus. The c-src gene consists of 12 exons; the boundaries of the exons were determined by assuming that the amino acid se...

journal_title：Cell

authors： Takeya T,Hanafusa H

更新日期：1983-03-01 00:00:00

abstract：:Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how th...

journal_title：Cell

authors： Kang SW,Hegde RS

更新日期：2008-11-28 00:00:00

abstract：:We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a pivotal role in converting tyrosine phosphorylation into the serine/threonine phosphorylations that regulate downstream events. We now describe cloning and characterization of two ERK1-related ...

journal_title：Cell

authors： Boulton TG,Nye SH,Robbins DJ,Ip NY,Radziejewska E,Morgenbesser SD,DePinho RA,Panayotatos N,Cobb MH,Yancopoulos GD

更新日期：1991-05-17 00:00:00