Abstract：
:Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known ligands. Known as orphan receptors, these proteins represent targets for novel signaling molecules. We have isolated a mammalian orphan receptor that forms a heterodimeric complex with the retinoid X receptor. A screen of candidate ligands identified farnesol and related metabolites as effective activators of this complex. Farnesol metabolites are generated intracellularly and are required for the synthesis of cholesterol, bile acids, steroids, retinoids, and farnesylated proteins. Intermediary metabolites have been recognized as transcriptional regulators in bacteria and yeast. Our results now suggest that metabolite-controlled intracellular signaling systems are utilized by higher organisms.
journal_name
Celljournal_title
Cellauthors
Forman BM,Goode E,Chen J,Oro AE,Bradley DJ,Perlmann T,Noonan DJ,Burka LT,McMorris T,Lamph WW,Evans RM,Weinberger Cdoi
10.1016/0092-8674(95)90530-8subject
Has Abstractpub_date
1995-06-02 00:00:00pages
687-93issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(95)90530-8journal_volume
81pub_type
杂志文章相关文献
CELL文献大全abstract：:Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA. ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s0092-8674(01)00509-8
更新日期：2001-10-05 00:00:00
abstract：:Plants, compared to animals, exhibit an amazing adaptability and plasticity in their development. This is largely dependent on the ability of plants to form new organs, such as lateral roots, leaves, and flowers during postembryonic development. Organ primordia develop from founder cell populations into organs by coor...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00924-3
更新日期：2003-11-26 00:00:00
abstract：:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption m...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.09.022
更新日期：2016-12-15 00:00:00
abstract：:The 2.6 Angstrom crystal structure for human cyclin-dependent kinase 2(CDK2) in complex with CksHs1, a human homolog of essential yeast cell cycle-regulatory proteins suc1 and Cks1, reveals that CksHs1 binds via all four beta strands to the kinase C-terminal lobe. This interface is biologically critical, based upon mu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81065-x
更新日期：1996-03-22 00:00:00
abstract：:Following DNA replication, eukaryotic cells must biorient all sister chromatids prior to cohesion cleavage at anaphase. In animal cells, sister chromatids gradually biorient during prometaphase, but current models of mitosis in S. cerevisiae assume that biorientation is established shortly after S phase. This assumpti...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.08.008
更新日期：2013-08-29 00:00:00
abstract：:The P7C3 class of aminopropyl carbazole chemicals fosters the survival of neurons in a variety of rodent models of neurodegeneration or nerve cell injury. To uncover its mechanism of action, an active derivative of P7C3 was modified to contain both a benzophenone for photocrosslinking and an alkyne for CLICK chemistry...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.07.040
更新日期：2014-09-11 00:00:00
abstract：:Mutations in the C. elegans gene ced-3 prevent almost all programmed cell deaths, so that in a ced-3 mutant there are many extra cells. We show that the pharyngeal neuron M4 is essential for feeding in wild-type worms, but in a ced-3 mutant, one of the extra cells, probably MSpaaaaap (the sister of M4), can sometimes ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90593-9
更新日期：1987-12-24 00:00:00
abstract：:The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear. We find that Stk25, a modifier of Reelin-Dab1 signaling, regulates Golgi morphology and neuronal polarization as part of an LKB1-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.10.029
更新日期：2010-11-24 00:00:00
abstract：:The dynamic synapse is represented by the constant mobility and exchange of components at both the cell surface and at intracellular sites. This includes thermally powered Brownian diffusion movement, followed by reversible trapping through receptor-scaffold interactions and active transport of cargo vesicles through ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.06.002
更新日期：2014-06-19 00:00:00
abstract：:We have isolated the bovine and human genes for Müllerian inhibiting substance (MIS), a testicular glycoprotein that causes regression of the Müllerian duct during development of the male embryo. The mRNA sequence of bovine MIS, determined from an analysis of cDNA and genomic clones, codes for a protein of 575 amino a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90783-x
更新日期：1986-06-06 00:00:00
abstract：:Nucleosome assembly following DNA replication and gene transcription is important to maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly. However, it is unknown how H3-H4 is transfe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.10.014
更新日期：2013-11-07 00:00:00
abstract：:Steroid hormones induce transcription from the mouse mammary tumor virus (MMTV) promoter by complex mechanisms requiring binding of the hormone receptors to the hormone responsive element (HRE) of the long terminal repeat region. Here we show that the MMTV promoter contains two degenerated octamer motifs immediately u...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90240-y
更新日期：1991-02-08 00:00:00
abstract：:Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres. Interbreeding of heterozygotes resulted in progressive telomere shortening, indicating...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.11.020
更新日期：2005-12-16 00:00:00
abstract：:Following EMS mutagenesis we recovered a mutant of D. melanogaster that grows at concentrations of alpha-amanitin lethal to wild-type. To our knowledge this mutant represents the first example of an amanitin-resistant eucaryotic organism. The amanitin resistance of the mutant (AmaC4) is due to an alteration in its DNA...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90116-8
更新日期：1979-11-01 00:00:00
abstract：:The switch from membrane-bound to secreted-form IgM that occurs during differentiation of B lymphocytes has long been known to involve regulated processing of the heavy chain pre-mRNA. Here, we show that accumulation of one subunit of an essential polyadenylation factor (CstF-64) is specifically repressed in mouse pri...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)82000-0
更新日期：1996-11-29 00:00:00
abstract：:P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants. We have found that a short segment near the amino terminus of PSGL-1 that contains a tyrosine sulfation consensus is essential for P-selectin adhesion and that...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90174-4
更新日期：1995-10-20 00:00:00
abstract：:We describe a new repressible binary expression system based on the regulatory genes from the Neurospora qa gene cluster. This "Q system" offers attractive features for transgene expression in Drosophila and mammalian cells: low basal expression in the absence of the transcriptional activator QF, high QF-induced expre...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.02.025
更新日期：2010-04-30 00:00:00
abstract：:As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information is generally carried on a circular chromosome with a single origin of replication from which two replication forks proceed bidirectionally toward the opposite terminus region. Here, we investigate the higher-order architecture o...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.12.027
更新日期：2018-02-08 00:00:00
abstract：:Morphogen gradients are typically analyzed from static images of fixed embryonic tissues. Two papers in this issue of Cell now report live imaging of the Bicoid gradient in developing fruit fly embryos (Gregor et al., 2007a, 2007b). Their findings indicate that the gradient is highly reproducible from embryo to embryo...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2007.06.036
更新日期：2007-07-13 00:00:00
abstract：:Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circa...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.04.020
更新日期：2013-05-09 00:00:00
abstract：:A gene, bcl-3, is found on chromosome 19 adjacent to the breakpoints in the translocation t(14;19)(q32;q13.1), which occurs in some cases of chronic lymphocytic leukemia. Sequence analysis of the human bcl-3 gene predicts a protein containing seven tandem copies of the SWI6/cdc10 motif. This motif was previously ident...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90347-h
更新日期：1990-03-23 00:00:00
abstract：:Twitter needs no introduction. This "microblogging" service has gained tremendous popularity in the 2 years since its launch. Yet, most scientists are steering clear of it. Laura Bonetta speaks to some who have found value in tweeting. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.10.017
更新日期：2009-10-30 00:00:00
abstract：:The budding yeast, Saccharomyces cerevisiae, has emerged as an archetype of eukaryotic cell biology. Here we show that S. cerevisiae is also a model for the evolution of cooperative behavior by revisiting flocculation, a self-adherence phenotype lacking in most laboratory strains. Expression of the gene FLO1 in the la...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.09.037
更新日期：2008-11-14 00:00:00
abstract：:In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting a...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2005.01.006
更新日期：2005-01-28 00:00:00
abstract：:The initiation of transcription from the nitrogen-regulated promoter glnAp2 requires RNA polymerase containing sigma 54, the transcriptional activator NRI, and the protein kinase NRII, responsible for the conversion of NRI to the active NRI-phosphate. NRI-phosphate does not increase the ability of sigma 54-containing ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90170-x
更新日期：1987-09-25 00:00:00
abstract：:Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal trans...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.10.005
更新日期：2007-10-19 00:00:00
abstract：:Biological membranes undergo constant remodeling by membrane fission and fusion to change their shape and to exchange material between subcellular compartments. During clathrin-mediated endocytosis, the dynamic assembly and disassembly of protein scaffolds comprising members of the bin-amphiphysin-rvs (BAR) domain pro...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2014.02.017
更新日期：2014-02-27 00:00:00
abstract：:Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs), but how histone recognition is achieved has not been established. Here we demonstrate that this link occurs through direct binding of 53BP1 and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.10.043
更新日期：2006-12-29 00:00:00
abstract：:Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their target selectivity...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.03.035
更新日期：2006-05-19 00:00:00
abstract：:Overlapping cDNA clones from the translocation breakpoint region (TBR) gene, recently discovered at the neurofibromatosis type 1 locus and found to be interrupted by deletions and a t(17;22) translocation, have been sequenced. A 4 kb sequence of the transcript of the TBR gene has been compared with sequences of genomi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90253-b
更新日期：1990-07-13 00:00:00
