Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors.

abstract：:The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of genome stability. We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator). TIGAR expression lowered fruc...

journal_title：Cell

authors： Bensaad K,Tsuruta A,Selak MA,Vidal MN,Nakano K,Bartrons R,Gottlieb E,Vousden KH

更新日期：2006-07-14 00:00:00

abstract：:Many proteins (intrinsically disordered proteins, IDPs) or regions of proteins (intrinsically disordered regions, IDRs) lack a well-defined 3D structure under physiological conditions. Albeit unfolded and highly dynamic, these proteins are not denatured; rather, intrinsic structural disorder is their native, functiona...

journal_title：Cell

authors： Guharoy M,Pauwels K,Tompa P

更新日期：2015-05-21 00:00:00

abstract：:Several recent papers show that differences in histone modification and the use of histone variants at the 5' and 3' ends of genes influence the location and kinetics of transcriptional initiation. The ultimate target of most epigenetic mechanisms may be the regulation of nucleosome occupancy, which in turn controls a...

journal_title：Cell

authors： Lieb JD,Clarke ND

更新日期：2005-12-29 00:00:00

abstract：:The yeast plasmid 2 micron circle actively maintains high but stable copy levels in the cell, even though the plasmid confers no selective advantage to its host. To address the mechanism by which stable copy control is achieved, we have examined the level of expression of the genes resident on the yeast plasmid 2 micr...

journal_title：Cell

authors： Som T,Armstrong KA,Volkert FC,Broach JR

更新日期：1988-01-15 00:00:00

abstract：:Previous work on Drosophila santomea suggested that its absence of abdominal pigmentation, compared to the other darkly pigmented species, is based on mutations in the cis-regulatory region of tan, inactivating the expression of that gene in the abdomen of D. santomea males and females. Our discovery that D. santomea ...

journal_title：Cell

authors： Matute DR,Butler IA,Coyne JA

更新日期：2009-12-11 00:00:00

abstract：:Using immobilized PDGF receptor as an affinity reagent, we purified an 85 kd protein (p85) from cell lysates and we cloned its cDNA. The protein contains an SH3 domain and two SH2 domains that are homologous to domains found in several receptor-associated enzymes. Recombinant p85 overexpressed in mammalian cells inhib...

journal_title：Cell

authors： Escobedo JA,Navankasattusas S,Kavanaugh WM,Milfay D,Fried VA,Williams LT

更新日期：1991-04-05 00:00:00

abstract：:Congenital scoliosis, a lateral curvature of the spine caused by vertebral defects, occurs in approximately 1 in 1,000 live births. Here we demonstrate that haploinsufficiency of Notch signaling pathway genes in humans can cause this congenital abnormality. We also show that in a mouse model, the combination of this g...

journal_title：Cell

authors： Sparrow DB,Chapman G,Smith AJ,Mattar MZ,Major JA,O'Reilly VC,Saga Y,Zackai EH,Dormans JP,Alman BA,McGregor L,Kageyama R,Kusumi K,Dunwoodie SL

更新日期：2012-04-13 00:00:00

abstract：:Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immu...

journal_title：Cell

authors： Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Sch

更新日期：2018-01-11 00:00:00

abstract：:Nucleosome assembly following DNA replication and gene transcription is important to maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly. However, it is unknown how H3-H4 is transfe...

journal_title：Cell

authors： Han J,Zhang H,Zhang H,Wang Z,Zhou H,Zhang Z

更新日期：2013-11-07 00:00:00

abstract：:The small ribonucleoproteins recognized by anti-La autoantibodies contain a heterogeneous mixture of small RNAs from uninfected mammalian cells. The identity of many of these has now been established by the discovery of precursor forms of 5S rRNA and of certain tRNAs among La RNAs from HeLa cells. The small fraction o...

journal_title：Cell

authors： Rinke J,Steitz JA

更新日期：1982-05-01 00:00:00

abstract：:We have developed a cell-free system for studying the integration of retroviral DNA. In our assay, amber mutations in a bacteriophage lambda genome that serves as the target for integration are suppressed by integration of an MLV derivative that carries the E. coli supF gene. The structure of the reaction products is ...

journal_title：Cell

authors： Brown PO,Bowerman B,Varmus HE,Bishop JM

更新日期：1987-05-08 00:00:00

abstract：:The mouse t haplotypes show defects in spermatogenesis attributed to multiple loci on chromosome 17. We have cloned the gene for an abundant testicular germ cell protein, t complex polypeptide 1, which has a variant form in t haplotypes, TCP-1A. A cDNA clone, pB1.4, which hybridizes to a 19S mRNA that is abundant in h...

journal_title：Cell

authors： Willison KR,Dudley K,Potter J

更新日期：1986-03-14 00:00:00

abstract：:Transfection experiments with HSV 1 in which one uses herpes simplex virus (HSV) thymidine kinase (TK) as a selectable prototrophic marker yield two classes of transformed cells: stable and unstable. In this report, we test the hypothesis that the stability phenotype can be explained by virus genome integration into a...

journal_title：Cell

authors： Smiley JR,Steege DA,Juricek DK,Summers WP,Ruddle FH

更新日期：1978-10-01 00:00:00

abstract：:The human immunodeficiency virus, the lentivirus that causes AIDS, is responsible for the most prevalent epidemic in the history of mankind. Here in this Timeline, we have attempted to illustrate a short history of HIV-1, from its identification in landmark papers published by Robert Gallo, Myron Essex, and Luc Montag...

journal_title：Cell

authors： Agarwal-Jans S

更新日期：2020-10-15 00:00:00

abstract：:A new class of endogenous primate type C virus has been isolated from a continuous tissue culture line of Macaca arctoides cells by co-cultivation with a human cell line. The virus, designated MAC-1, can be transmitted to human and feline cells in tissue culture, and is unrelated, by immunological and nucleic acid hyb...

journal_title：Cell

authors： Todaro GJ,Benveniste RE,Sherwin SA,Sherr CJ

更新日期：1978-04-01 00:00:00

abstract：:We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spi...

journal_title：Cell

authors： Kasthuri N,Hayworth KJ,Berger DR,Schalek RL,Conchello JA,Knowles-Barley S,Lee D,Vázquez-Reina A,Kaynig V,Jones TR,Roberts M,Morgan JL,Tapia JC,Seung HS,Roncal WG,Vogelstein JT,Burns R,Sussman DL,Priebe CE,Pfister H

更新日期：2015-07-30 00:00:00

abstract：:Analysis of the in vitro splicing products of RNA precursors containing tandem duplications of the 5' or 3' splice sites of human beta-globin IVS 1 revealed that exon sequences play an important role in the relative use of the duplicated sites. These studies also show that the proximity of the 5' and 3' splice sites i...

journal_title：Cell

authors： Reed R,Maniatis T

更新日期：1986-08-29 00:00:00

abstract：:Ubiquitin-conjugating enzyme variant (UEV) proteins resemble ubiquitin-conjugating enzymes (E2s) but lack the defining E2 active-site residue. The MMS2-encoded UEV protein has been genetically implicated in error-free postreplicative DNA repair in Saccharomyces cerevisiae. We show that Mms2p forms a specific heteromer...

journal_title：Cell

authors： Hofmann RM,Pickart CM

更新日期：1999-03-05 00:00:00

abstract：:A gene, bcl-3, is found on chromosome 19 adjacent to the breakpoints in the translocation t(14;19)(q32;q13.1), which occurs in some cases of chronic lymphocytic leukemia. Sequence analysis of the human bcl-3 gene predicts a protein containing seven tandem copies of the SWI6/cdc10 motif. This motif was previously ident...

journal_title：Cell

authors： Ohno H,Takimoto G,McKeithan TW

更新日期：1990-03-23 00:00:00

abstract：:Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...

journal_title：Cell

authors： Klein R

更新日期：2010-10-01 00:00:00

abstract：:The unfolded protein response (UPR) regulates gene expression in response to stress in the endoplasmic reticulum (ER). We determined the transcriptional scope of the UPR using DNA microarrays. Rather than regulating only ER-resident chaperones and phospholipid biosynthesis, as anticipated from earlier work, the UPR af...

journal_title：Cell

authors： Travers KJ,Patil CK,Wodicka L,Lockhart DJ,Weissman JS,Walter P

更新日期：2000-04-28 00:00:00

abstract：:Cancer cell of origin is difficult to identify by analyzing cells within terminal stage tumors, whose identity could be concealed by the acquired plasticity. Thus, an ideal approach to identify the cell of origin is to analyze proliferative abnormalities in distinct lineages prior to malignancy. Here, we use mosaic an...

journal_title：Cell

authors： Liu C,Sage JC,Miller MR,Verhaak RG,Hippenmeyer S,Vogel H,Foreman O,Bronson RT,Nishiyama A,Luo L,Zong H

更新日期：2011-07-22 00:00:00

abstract：:Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver, a chemical modification known to ...

journal_title：Cell

authors： Sharabi K,Lin H,Tavares CDJ,Dominy JE,Camporez JP,Perry RJ,Schilling R,Rines AK,Lee J,Hickey M,Bennion M,Palmer M,Nag PP,Bittker JA,Perez J,Jedrychowski MP,Ozcan U,Gygi SP,Kamenecka TM,Shulman GI,Schreiber SL,Gr

更新日期：2017-03-23 00:00:00

abstract：:Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics. Stem cell factor (SCF) is a growth factor that acts throu...

journal_title：Cell

authors： Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC

更新日期：2017-03-09 00:00:00

abstract：:The tra-1 gene plays a central role in C. elegans sex determination. XX animals develop as hermaphrodites when tra-1 is active and as males when it is not. By analyzing a large number of tra-1 genetic mosaics we have shown that, with the expected exception of vulval induction by the hermaphrodite gonad, tra-1 function...

journal_title：Cell

authors： Hunter CP,Wood WB

更新日期：1990-12-21 00:00:00

abstract：:Replication of Escherichia coli plasmid p15A was examined by use of a cell extract or a mixture of three purified E. coli enzymes: RNA polymerase; RNAase H; and DNA polymerase I. In each system, replication initiates at any of three consecutive nucleotides located at a unique site. Primer transcription starts 508 bp u...

journal_title：Cell

authors： Selzer G,Som T,Itoh T,Tomizawa J

更新日期：1983-01-01 00:00:00

abstract：:A recombinant peptide encoding the CD11b A domain bound 54Mn2+ with a high affinity. Other divalent cations, including Mg2+, Zn2+, Ni2+, Co2+, and Cd2+, but not Ca2+ or Ba2+, competed effectively for Mn2+ binding. Amino acid substitutions within two conserved and noncontiguous regions in the recombinant peptide abolis...

journal_title：Cell

authors： Michishita M,Videm V,Arnaout MA

更新日期：1993-03-26 00:00:00

abstract：:Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collectiv...

journal_title：Cell

authors： Ananthanarayanan V,Schattat M,Vogel SK,Krull A,Pavin N,Tolić-Nørrelykke IM

更新日期：2013-06-20 00:00:00

abstract：:During early Drosophila embryogenesis, several zygotic gene products act to establish a posttranscriptional activity gradient of the morphogen DPP. Among these molecules, Tolloid, a putative metalloprotease related to BMP-1, enhances DPP function, while SOG, an ortholog of the Xenopus organizer Chordin, inhibits DPP f...

journal_title：Cell

authors： Marqués G,Musacchio M,Shimell MJ,Wünnenberg-Stapleton K,Cho KW,O'Connor MB

更新日期：1997-10-31 00:00:00

abstract：:Type I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signaling (MAVS) proteins mediate IFN production in response to cytosolic double-stranded RNA or single-stranded RNA containing 5'-triphosphate (5'-ppp). Cytosolic B form dou...

journal_title：Cell

authors： Chiu YH,Macmillan JB,Chen ZJ

更新日期：2009-08-07 00:00:00