Abstract：
:In many organisms, meiotic chromosomes are bundled at their telomeres to form a "bouquet" arrangement. The bouquet formation plays an important role in homologous chromosome pairing and therefore progression of meiosis. As meiotic telomere clustering occurs in response to mating pheromone signaling in fission yeast, we looked for factors essential for bouquet formation among genes induced under mating pheromone signaling. This genome-wide search identified two proteins, Bqt1 and Bqt2, that connect telomeres to the spindle-pole body (SPB; the centrosome equivalent in fungi). Neither Bqt1 nor Bqt2 alone functions as a connector, but together the two proteins form a bridge between Rap1 (a telomere protein) and Sad1 (an SPB protein). Significantly, when both Bqt1 and Bqt2 are ectopically expressed in mitotic cells, they also form a bridge between Rap1 and Sad1. Thus, a complex including Bqt1 and Bqt2 is essential for connecting telomeres to the SPB.
journal_name
Celljournal_title
Cellauthors
Chikashige Y,Tsutsumi C,Yamane M,Okamasa K,Haraguchi T,Hiraoka Ydoi
10.1016/j.cell.2006.01.048subject
Has Abstractpub_date
2006-04-07 00:00:00pages
59-69issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(06)00318-7journal_volume
125pub_type
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