The Interfaces of Genetic Conflict Are Hot Spots for Innovation.

abstract：:Strains of Saccharomyces that carry the nib allele of a nuclear gene exhibit a "nibbled" colony morphology if they also harbor the plasmid 2 mu DNA. I have found that the expression of the nibbled phenotype is correlated with the presence of a subpopulation of abnormally large cells that give rise to mortal clones. La...

journal_title：Cell

authors： Holm C

更新日期：1982-06-01 00:00:00

abstract：:Developing systems exhibit robust and tolerant properties in the form of compensation and competition within cell groups. Fundamentally, these behaviors are governed by mechanisms that elicit proliferation and apoptosis. Recent insights from the Drosophila system implicate new determinants that specify "winners" and "...

journal_title：Cell

authors： Abrams JM

更新日期：2002-08-23 00:00:00

abstract：:Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen. Histone chaperones (Chaf1a/b), sumoylation factors ...

journal_title：Cell

authors： Yang BX,El Farran CA,Guo HC,Yu T,Fang HT,Wang HF,Schlesinger S,Seah YF,Goh GY,Neo SP,Li Y,Lorincz MC,Tergaonkar V,Lim TM,Chen L,Gunaratne J,Collins JJ,Goff SP,Daley GQ,Li H,Bard FA,Loh YH

更新日期：2015-09-24 00:00:00

abstract：:The distribution of microfilament bundles in cells was examined using antibodies to fibroblast myosin and indirect immunofluorescence microscopy. There is no correlation between the presence of bundles of microfilaments and normal growth control. A normal cell line (Balb/c 3T3) cultured on a poorly adhesive substratum...

journal_title：Cell

authors： Willingham MC,Yamada KM,Yamada SS,Pouysségur J,Pastan I

更新日期：1977-03-01 00:00:00

abstract：:Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural ac...

journal_title：Cell

authors： Markowitz JE,Gillis WF,Beron CC,Neufeld SQ,Robertson K,Bhagat ND,Peterson RE,Peterson E,Hyun M,Linderman SW,Sabatini BL,Datta SR

更新日期：2018-06-28 00:00:00

abstract：:We investigated a herpesvirus mutant that contains a single base insertion in its thymidine kinase (tk) gene yet expresses low levels of TK via a net +1 translational recoding event. Within this mutant gene, we defined a G-rich signal that is sufficient to induce recoding. Unlike other translational recoding events, d...

journal_title：Cell

authors： Horsburgh BC,Kollmus H,Hauser H,Coen DM

更新日期：1996-09-20 00:00:00

abstract：:The yeast Sir2/3/4p complex is found in abundance at telomeres, where it participates in the formation of silent heterochromatin and telomere maintenance. Here, we show that Sir3p is released from telomeres in response to DNA double-strand breaks (DSBs), binds to DSBs, and mediates their repair, independent of cell ma...

journal_title：Cell

authors： Mills KD,Sinclair DA,Guarente L

更新日期：1999-05-28 00:00:00

abstract：:The modularity of protein architecture and the diversity of protein domains hint at a vast combinatorial richness. But evolution appears to have been relatively conservative about selecting new combinations. When a particular grouping of domains within a polypeptide chain can perform a concerted function, that combina...

journal_title：Cell

authors： Harrison SC

更新日期：2003-03-21 00:00:00

abstract：:Of the several families of adhesion receptors involved in leukocyte-endothelial cell interactions, only the selectins have been shown to initiate leukocyte interaction under physiologic shear; indeed, beta 2 (CD18) intergrins responsible for neutrophil arrest are unable to engage without prior selectin-mediated rollin...

journal_title：Cell

authors： Berlin C,Bargatze RF,Campbell JJ,von Andrian UH,Szabo MC,Hasslen SR,Nelson RD,Berg EL,Erlandsen SL,Butcher EC

更新日期：1995-02-10 00:00:00

abstract：:The stomata of plants regulate gas exchange and water transpiration in response to changing environmental conditions. New work reveals that stomata also have an important role in host defense. In this issue of Cell, Melotto et al. (2006) show that stomata close upon detection of potential microbial pathogens to preven...

journal_title：Cell

authors： Schulze-Lefert P,Robatzek S

更新日期：2006-09-08 00:00:00

abstract：:Francis' office window (at the Salk) commanded a panorama of the Pacific. "This grand natural scene was a physical correlate of Francis's intellectual world: wide-ranging, brilliantly lit, a little overawing, but also immensely inviting and above all an exciting place to be." (Mitchison, 2004). ...

journal_title：Cell

authors： Lawrence PA

更新日期：2016-12-01 00:00:00

abstract：:In a screen for genes that interact with the Rap1 GTPase, we have identified a Drosophila gene, dacapo (dap), which is a member of the p21/p27 family of cdk inhibitors. Unlike mammalian cdk inhibitors studied to date, dap is essential for normal embryonic development. Dacapo inhibits cyclin-cdk activity in vitro. Over...

journal_title：Cell

authors： de Nooij JC,Letendre MA,Hariharan IK

更新日期：1996-12-27 00:00:00

abstract：:We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which ...

journal_title：Cell

authors： Ahmed Y,Hayashi S,Levine A,Wieschaus E

更新日期：1998-06-26 00:00:00

abstract：:To relate different forms of synaptic plasticity to the formation and maintenance of place cells in the hippocampus, we have recorded place cells in freely behaving, transgenic mice that express a mutated Ca2+-independent form of CaM Kinase II. These mice have normal long-term potentiation (LTP) at 100 Hz, but they la...

journal_title：Cell

authors： Rotenberg A,Mayford M,Hawkins RD,Kandel ER,Muller RU

更新日期：1996-12-27 00:00:00

abstract：:Septate and tight junctions are thought to seal neighboring cells together and to function as barriers between epithelial cells. We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. NRX is a transmembrane protein wi...

journal_title：Cell

authors： Baumgartner S,Littleton JT,Broadie K,Bhat MA,Harbecke R,Lengyel JA,Chiquet-Ehrismann R,Prokop A,Bellen HJ

更新日期：1996-12-13 00:00:00

abstract：:DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify add...

journal_title：Cell

authors： Freudenthal BD,Beard WA,Shock DD,Wilson SH

更新日期：2013-07-03 00:00:00

abstract：:Polycomb group (PcG) proteins form large multimeric complexes (PcG bodies) which are involved in the stable repression of gene expression. The human PcG protein, Pc2, has been shown to recruit the transcriptional corepressor, CtBP, to PcG bodies. We show that CtBP is sumoylated at a single lysine. In vitro, CtBP sumoy...

journal_title：Cell

authors： Kagey MH,Melhuish TA,Wotton D

更新日期：2003-04-04 00:00:00

abstract：:The adenovirus E1a region encodes two closely related gene products: 243 and 289 amino acid phosphoproteins. These proteins differ in their primary sequence only by 46 amino acids unique to the 289 amino acid protein. By constructing single-base substitution mutants we localized two functional regions of these E1a pro...

journal_title：Cell

authors： Lillie JW,Green M,Green MR

更新日期：1986-09-26 00:00:00

abstract：:A general strategy is described for the isolation of suppressors of essential genes whose functions are unknown. This strategy was used to analyze the role of 4.5S RNA, an essential RNA of E. coli. In this strategy, the structural gene for 4.5S RNA is fused to the Ptac promoter in such a way that the strain becomes de...

journal_title：Cell

authors： Brown S

更新日期：1987-06-19 00:00:00

abstract：:How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are shaped by the reticulons and DP1/Yop1p, whereas their fusion into a network is brought about by membrane-bound GTPases that in...

journal_title：Cell

authors： Hu J,Prinz WA,Rapoport TA

更新日期：2011-12-09 00:00:00

abstract：:Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging in Drosophila. We show that inhibition of Ras is sufficient for lifespan extension downstream of reduced...

journal_title：Cell

authors： Slack C,Alic N,Foley A,Cabecinha M,Hoddinott MP,Partridge L

更新日期：2015-07-02 00:00:00

abstract：:A unique DNA structural intermediate associated with termination of replication in Bacillus subtilis has been identified. This was achieved by probing for the Bam HI DNA fragment within which the terminus of the chromosome (terC) resides. The intermediate migrates more slowly than the bulk of digested chromosomal DNA ...

journal_title：Cell

authors： Weiss AS,Wake RG

更新日期：1984-12-01 00:00:00

abstract：:Most human epithelial tumors harbor numerous alterations, making it difficult to predict which genes are required for tumor survival. To systematically identify cancer dependencies, we analyzed 501 genome-scale loss-of-function screens performed in diverse human cancer cell lines. We developed DEMETER, an analytical f...

journal_title：Cell

authors： Tsherniak A,Vazquez F,Montgomery PG,Weir BA,Kryukov G,Cowley GS,Gill S,Harrington WF,Pantel S,Krill-Burger JM,Meyers RM,Ali L,Goodale A,Lee Y,Jiang G,Hsiao J,Gerath WFJ,Howell S,Merkel E,Ghandi M,Garraway LA,Roo

更新日期：2017-07-27 00:00:00

abstract：:A key aspect of genomic medicine is to make individualized clinical decisions from personal genomes. We developed a machine-learning framework to integrate personal genomes and electronic health record (EHR) data and used this framework to study abdominal aortic aneurysm (AAA), a prevalent irreversible cardiovascular ...

journal_title：Cell

authors： Li J,Pan C,Zhang S,Spin JM,Deng A,Leung LLK,Dalman RL,Tsao PS,Snyder M

更新日期：2018-09-06 00:00:00

abstract：:The ClyA protein is a pore-forming cytotoxin expressed by Escherichia coli and some other enterobacteria. It confers cytotoxic activity toward mammalian cells, but it has remained unknown how ClyA is surface exposed and exported from bacterial cells. Outer-membrane vesicles (OMVs) released from the bacteria were shown...

journal_title：Cell

authors： Wai SN,Lindmark B,Söderblom T,Takade A,Westermark M,Oscarsson J,Jass J,Richter-Dahlfors A,Mizunoe Y,Uhlin BE

更新日期：2003-10-03 00:00:00

abstract：:Adult neovascularization relies on the recruitment of circulating cells, but their angiogenic roles and recruitment mechanisms are unclear. We show that the endothelial growth factor VEGF is sufficient for organ homing of circulating mononuclear myeloid cells and is required for their perivascular positioning and rete...

journal_title：Cell

authors： Grunewald M,Avraham I,Dor Y,Bachar-Lustig E,Itin A,Jung S,Chimenti S,Landsman L,Abramovitch R,Keshet E

更新日期：2006-01-13 00:00:00

abstract：:Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for neural development, and brain cells frequently contain somatic genomic variations that might involve DSB intermediates. We now use an unbiased, high-throughput approach to identify genomic regions harboring recurrent DSBs in primar...

journal_title：Cell

authors： Wei PC,Chang AN,Kao J,Du Z,Meyers RM,Alt FW,Schwer B

更新日期：2016-02-11 00:00:00

abstract：:Extraction of glycerinated chicken skeletal muscle with 0.6 M potassium iodide leaves a framework of insoluble components within each muscle fiber. This framework is composed primarily of planes of in-register Z discs that have been thickened by the accumulation of material on both sides of each disc during extraction...

journal_title：Cell

authors： Granger BL,Lazarides E

更新日期：1978-12-01 00:00:00

abstract：:We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED-3 protein shows similarity to human and murine interleukin-1 beta-converting enzyme and to the product of the mouse nedd-2 gene, whi...

journal_title：Cell

authors： Yuan J,Shaham S,Ledoux S,Ellis HM,Horvitz HR

更新日期：1993-11-19 00:00:00

abstract：:The Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomerizes and permeabilizes the mitochondrial outer membrane to promote apoptosis. Bax activity is counteracted by prosurvival Bcl-2 proteins, but how they inhibit Bax remains controversial because they neither colocalize nor form s...

journal_title：Cell

authors： Edlich F,Banerjee S,Suzuki M,Cleland MM,Arnoult D,Wang C,Neutzner A,Tjandra N,Youle RJ

更新日期：2011-04-01 00:00:00