Abstract:
:The LIM domain protein rbtn2 is associated with T cell acute leukemias. We demonstrate that rbtn2 is a nuclear protein expressed in the erythroid lineage in vivo, and using homologous recombination, we show that it is essential for erythroid development in mice. The homozygous rbtn2 null mutation leads to failure of yolk sac erythropoiesis and embryonic lethality around E10.5. Moreover, in vitro differentiation of yolk sac tissue from homozygous mutant mice and sequentially targeted double-mutant ES cells demonstrates a block to erythroid development. This shows a pivotal role for a LIM domain protein in lineage specification during mammalian development and suggests that RBTN2 and GATA-1 are critical at similar stages of erythroid differentiation.
journal_name
Celljournal_title
Cellauthors
Warren AJ,Colledge WH,Carlton MB,Evans MJ,Smith AJ,Rabbitts THdoi
10.1016/0092-8674(94)90571-1subject
Has Abstractpub_date
1994-07-15 00:00:00pages
45-57issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(94)90571-1journal_volume
78pub_type
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