The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development.

Abstract:

:The LIM domain protein rbtn2 is associated with T cell acute leukemias. We demonstrate that rbtn2 is a nuclear protein expressed in the erythroid lineage in vivo, and using homologous recombination, we show that it is essential for erythroid development in mice. The homozygous rbtn2 null mutation leads to failure of yolk sac erythropoiesis and embryonic lethality around E10.5. Moreover, in vitro differentiation of yolk sac tissue from homozygous mutant mice and sequentially targeted double-mutant ES cells demonstrates a block to erythroid development. This shows a pivotal role for a LIM domain protein in lineage specification during mammalian development and suggests that RBTN2 and GATA-1 are critical at similar stages of erythroid differentiation.

journal_name

Cell

journal_title

Cell

authors

Warren AJ,Colledge WH,Carlton MB,Evans MJ,Smith AJ,Rabbitts TH

doi

10.1016/0092-8674(94)90571-1

subject

Has Abstract

pub_date

1994-07-15 00:00:00

pages

45-57

issue

1

eissn

0092-8674

issn

1097-4172

pii

0092-8674(94)90571-1

journal_volume

78

pub_type

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