Abstract：
:The yeast tropomyosin gene, designated TPM1, is present in a single copy per haploid genome and encodes a protein with a predicted molecular weight of 23.5 kd. The protein sequence is homologous to higher cell tropomyosins, including the characteristic hydrophobic-hydrophilic pseudoheptapeptide repeats. Indirect immunofluorescence microscopy reveals that tropomyosin is localized with actin cables in wild-type cells. Disruption of TPM1 is not lethal, but results in a reduced growth rate and disappearance of actin cables. Strains carrying the conditional actin mutation act1-2 also lack actin cables; overexpression of tropomyosin in these strains partially restores actin cables. These results strongly suggest that tropomyosin interacts with F actin in vivo and may play an important role in assembling or stabilizing actin cables in yeast.
journal_name
Celljournal_title
Cellauthors
Liu HP,Bretscher Adoi
10.1016/0092-8674(89)90961-6subject
Has Abstractpub_date
1989-04-21 00:00:00pages
233-42issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(89)90961-6journal_volume
57pub_type
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