Abstract：
:To investigate the function of SWI/SNF in site-specific chromatin remodeling at promoters, we have used a purified system to analyze its distribution, function, and retention following recruitment by a sequence-specific transcription activator. Activator recruitment of SWI/SNF bound the complex to promoter proximal nucleosomes and led to localized nucleosome disruption. However, retention of SWI/SNF on the promoter required either the continued binding of the transcription activator or acetylated histones. Histone acetylation by either the SAGA or NuA4 HAT complexes increased the retention of SWI/SNF on the promoter. These data illustrate a functional link between HAT complexes and the SWI/SNF chromatin remodeling complex and provide a mechanistic basis for the ordered recruitment of these complexes.
journal_name
Celljournal_title
Cellauthors
Hassan AH,Neely KE,Workman JLdoi
10.1016/s0092-8674(01)00279-3subject
Has Abstractpub_date
2001-03-23 00:00:00pages
817-27issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(01)00279-3journal_volume
104pub_type
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