Abstract:
:Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a widespread health scare. On the other hand, the biology of prions represents a fascinating and poorly understood phenomenon, which may account for more than just diseases and may represent a fundamental mechanism of crosstalk between proteins. The two decades since Stanley Prusiner's formulation of the protein-only hypothesis have witnessed spectacular advances, and yet some of the most basic questions in prion science have remained unanswered.
journal_name
Celljournal_title
Cellauthors
Aguzzi A,Polymenidou Mdoi
10.1016/s0092-8674(03)01031-6subject
Has Abstractpub_date
2004-01-23 00:00:00pages
313-27issue
2eissn
0092-8674issn
1097-4172pii
S0092867403010316journal_volume
116pub_type
杂志文章,评审相关文献
CELL文献大全abstract::In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new ligh...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2009.12.036
更新日期:2010-01-08 00:00:00
abstract::Subsets of long-lived, tumor-initiating stem cells often escape cancer therapies. However, sources and mechanisms that generate tumor heterogeneity and drug-resistant cell population are still unfolding. Here, we devise a functional reporter system to lineage trace and/or genetic ablate signaling in TGF-β-activated sq...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.01.043
更新日期:2015-02-26 00:00:00
abstract::Assessing the real-world impact of biomedical research is notoriously difficult. Here, we present the framework for building a prospective science-centered information system from scratch that has been afforded by the Sidra Medical and Research Center in Qatar. This experiment is part of the global conversation on max...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.03.004
更新日期:2016-03-24 00:00:00
abstract::The intestinal microbiota produces tens of thousands of metabolites. Here, we used host sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate bioactive microbial metabolites that impact host physiology. We screened 144 human gut bacteria against the non-olfactory GPCRome and identif...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.03.036
更新日期:2019-05-16 00:00:00
abstract::Fibrillar protein aggregates are the major pathological hallmark of several incurable, age-related, neurodegenerative disorders. These aggregates typically contain aggregation-prone pathogenic proteins, such as amyloid-beta in Alzheimer's disease and alpha-synuclein in Parkinson's disease. It is, however, poorly under...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.07.020
更新日期:2010-08-20 00:00:00
abstract::A complete human gamma 1 heavy chain gene (HIG1) was transferred into mouse cells by protoplast fusion. The HIG1 gene was strongly expressed in mouse myeloma cells but not in mouse fibroblasts (L cells). Nuclear extracts from myeloma cells were injected into L cell transformants containing one copy of the HIG1 gene; t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90534-9
更新日期:1986-04-11 00:00:00
abstract::Most bacteria that colonize eukaryotes must bind directly to host cells to establish a replicative niche. In enteric bacteria, adhesion to host cells is often promoted by a lectin found on surface-localized pili. Some pili promote efficient adhesion only when they are subjected to shear stress, as found during the flo...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(02)00821-8
更新日期:2002-07-12 00:00:00
abstract::How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulat...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2012.06.020
更新日期:2012-07-06 00:00:00
abstract::An essential yeast protein, Nup145p, is identified via its genetic interaction with the nucleoporin Nsp1p. Nup145p contains GLFG repeats and localizes to nuclear pores. Depletion of Nup145p in vivo leads rapidly to nuclear retention of polyadenylated RNAs and more slowly to cytoplasmic accumulation of a nuclear report...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90297-6
更新日期:1994-07-29 00:00:00
abstract::Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a ne...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2010.12.003
更新日期:2010-12-23 00:00:00
abstract::The structure of the complex formed by the arginine-rich motif of the transcriptional antitermination protein N of phage lambda and boxB RNA was determined by heteronuclear magnetic resonance spectroscopy. A bent alpha helix in N recognizes primarily the shape and negatively charged surface of the boxB hairpin through...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81579-2
更新日期:1998-04-17 00:00:00
abstract::Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuro...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.08.035
更新日期:2009-10-16 00:00:00
abstract::Suppressor of Hairless (Su(H)) is required at two stages of adult sensory organ development in Drosophila. Complete loss of Su(H) function results in a "neurogenic" phenotype in imaginal discs, in which too many cells adopt the sensory organ precursor cell fate. Su(H) is also involved in controlling the fates of sensi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90641-o
更新日期:1992-06-26 00:00:00
abstract::We have isolated cDNA clones encoding the four different forms of mouse myelin basic protein (MBP) and have analyzed the structure of the MBP gene. The three larger forms of MBP differ from the smallest by the inclusion of either or both of two short amino acid sequences at positions 57 and 124 of the smallest protein...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90245-4
更新日期:1985-12-01 00:00:00
abstract::Long pyrimidine tracts, purified from Drosophila melanogaster DNA after treatment with formic acid-diphenylamine, were used as template for E. coli RNA polymerase to produce a polynucleotide containing only purines. This polypurine RNA hybridized specifically to D. melanogaster DNA with high efficiency at low Cot valu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90026-4
更新日期:1975-06-01 00:00:00
abstract::The chromosomal distributions of five families of mouse r-protein genes (S16, L18, L19, L30 and L32/33) were studied by Southern blot analysis of DNa from a panel of mouse-hamster hybrid cells containing various complements of mouse chromosomes. Our results indicated that members of a particular family are often locat...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90320-2
更新日期:1981-05-01 00:00:00
abstract::On each side of the midline of the Drosophila CNS, axons are organized into a series of parallel pathways. Here we show that the midline repellent Slit, previously identified as a short-range signal that regulates midline crossing, also functions at long range to pattern these longitudinal pathways. In this long-range...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)00207-5
更新日期:2000-12-22 00:00:00
abstract::Post-translational modifications of histone proteins and exchanges of histone variants of chromatin are central to the regulation of nearly all DNA-templated biological processes. However, the degree and variability of chromatin modifications in specific human immune cells remain largely unknown. Here, we employ a hig...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.079
更新日期:2018-05-31 00:00:00
abstract::TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(03)00432-x
更新日期:2003-06-13 00:00:00
abstract::Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Al...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2010.02.016
更新日期:2010-03-19 00:00:00
abstract::Initiator tRNAs from the cytoplasm of salmon testes and salmon liver have been purified. The nucleotide sequence of these initiator tRNAs has been determined and found identical to that of initiator tRNA from mammalian cytoplasm. The only difference is the extent of modification of the nuceloside located between the d...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90189-0
更新日期:1975-11-01 00:00:00
abstract::The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(78)90081-8
更新日期:1978-09-01 00:00:00
abstract::We have obtained the complete sequence of cloned full-length DNA (NS DNA) derived from influenza virus gene 8, which codes for two unique polypeptides, NS1 and NS2, and the sequence of the NS2 mRNA. Previously we showed that the mRNA for NS1 (approximately 860 nucleotides) is colinear with the viral RNA and maps from ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90484-5
更新日期:1980-09-01 00:00:00
abstract::Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or irri...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.12.002
更新日期:2020-01-09 00:00:00
abstract::The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while increasing network excitability. In addition, loss of PKR i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.11.029
更新日期:2011-12-09 00:00:00
abstract::Mature HIV-1 particles contain conical-shaped capsids that enclose the viral RNA genome and perform essential functions in the virus life cycle. Previous structural analysis of two- and three-dimensional arrays of the capsid protein (CA) hexamer revealed three interfaces. Here, we present a cryoEM study of a tubular a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.10.010
更新日期:2009-11-13 00:00:00
abstract::We have purified and characterized a modified peptide pheromone that accumulates in culture medium as B. subtilis grows to high density. This pheromone is required for the development of genetic competence. When added to cells at low density, the pheromone induces the premature development of competence. The peptide m...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90313-1
更新日期:1994-04-22 00:00:00
abstract::Immunofluorescent staining of a pericellular matrix produced by cultured human embryonic skin fibroblasts showed a codistribution among fibronectin, heparan sulfate proteoglycans and part of the chondroitin sulfate in a fibrillar network. Isolated matrix in an "intact" form could be scraped off the dish after detergen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90221-5
更新日期:1982-03-01 00:00:00
abstract::Exchange factors for ARF GTPases (ARF-GEFs) regulate vesicle trafficking in a variety of organisms. The Arabidopsis protein GNOM is a brefeldin A (BFA) sensitive ARF-GEF that is required for the proper polar localization of PIN1, a candidate transporter of the plant hormone auxin. Mutations in GNOM lead to development...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00003-5
更新日期:2003-01-24 00:00:00
abstract::In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. (2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2009.09.001
更新日期:2009-09-18 00:00:00