Abstract：
:Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a widespread health scare. On the other hand, the biology of prions represents a fascinating and poorly understood phenomenon, which may account for more than just diseases and may represent a fundamental mechanism of crosstalk between proteins. The two decades since Stanley Prusiner's formulation of the protein-only hypothesis have witnessed spectacular advances, and yet some of the most basic questions in prion science have remained unanswered.
journal_name
Celljournal_title
Cellauthors
Aguzzi A,Polymenidou Mdoi
10.1016/s0092-8674(03)01031-6subject
Has Abstractpub_date
2004-01-23 00:00:00pages
313-27issue
2eissn
0092-8674issn
1097-4172pii
S0092867403010316journal_volume
116pub_type
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