Abstract：
:The GPA1 gene of S. cerevisiae encodes a G alpha subunit that plays a positive role in the transduction of signals stimulating recovery from pheromone-induced cell cycle arrest. The GPA1Val50 mutation, in which Gly-50 is replaced by valine, causes hyperadaptation to pheromone. However, GPA1Val50 cells do not recover from division arrest in the absence of both CLN1 and CLN3, which encode G1 cyclins, indicating that the recovery-promoting activity of GPA1Val50 requires the function of G1 cyclins. An sgv1 mutation suppresses the hyperadaptive response caused by GPA1Val50 and also confers cold- and temperature-sensitive growth. The SGV1 gene encodes an apparent protein kinase homologous to CDC28/cdc2 kinase: SGV1 is 42% identical to CDC28. The activated mutation, CLN3-2, partially suppresses the growth defect of sgv1, suggesting that the SGV1 and CLN3 proteins may act in the same growth control pathway.
journal_name
Celljournal_title
Cellauthors
Irie K,Nomoto S,Miyajima I,Matsumoto Kdoi
10.1016/0092-8674(91)90386-dsubject
Has Abstractpub_date
1991-05-31 00:00:00pages
785-95issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(91)90386-Djournal_volume
65pub_type
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