Abstract：
:The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list-reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the "tumor microenvironment." Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
journal_name
Celljournal_title
Cellauthors
Hanahan D,Weinberg RAdoi
10.1016/j.cell.2011.02.013subject
Has Abstractpub_date
2011-03-04 00:00:00pages
646-74issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(11)00127-9journal_volume
144pub_type
杂志文章,评审相关文献
CELL文献大全abstract：:Cellular functioning requires the orchestration of thousands of molecular interactions in time and space. Yet most molecules in a cell move by diffusion, which is sensitive to external factors like temperature. How cells sustain complex, diffusion-based systems across wide temperature ranges is unknown. Here, we uncov...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.10.017
更新日期：2020-12-10 00:00:00
abstract：:During cell division, newly replicated DNA is actively segregated to the daughter cells. In most bacteria, this process involves the DNA-binding protein ParB, which condenses the centromeric regions of sister DNA molecules into kinetochore-like structures that recruit the DNA partition ATPase ParA and the prokaroytic ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.11.015
更新日期：2019-12-12 00:00:00
abstract：:Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We id...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.08.029
更新日期：2005-09-23 00:00:00
abstract：:Rubisco, the key enzyme of CO2 fixation in photosynthesis, is prone to inactivation by inhibitory sugar phosphates. Inhibited Rubisco undergoes conformational repair by the hexameric AAA+ chaperone Rubisco activase (Rca) in a process that is not well understood. Here, we performed a structural and mechanistic analysis...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.09.010
更新日期：2020-10-15 00:00:00
abstract：:Elements controlling tissue-specific expression of the rat albumin gene reside within roughly 150 bp upstream of the transcriptional initiation site. We show here by DNAase I footprinting assays that at least four distinct factors present in extracts derived from cells expressing albumin interact with these sequences....
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90036-5
更新日期：1987-08-14 00:00:00
abstract：:During HIV infection, the timing of opportunistic infections is not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens reactivate at different CD4 T cell thresholds. Here, we examine how differences in the phenotype and function of pathogen-specific CD4 T cells influence sus...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.09.045
更新日期：2013-10-24 00:00:00
abstract：:In extracts from rat and calf uterus, the steroid hormone 17 beta-estradiol stimulates the binding of its specific receptor protein to DNA. This interaction appears to be of low affinity (half of the estradiol-activated, 5S receptor bound at 300-400 mug/ml DNA) and nonspecific with respect to DNA base sequence. No bin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90150-6
更新日期：1975-04-01 00:00:00
abstract：:The light-sensing organelle of the vertebrate rod photoreceptor, the outer segment (OS), is a modified cilium containing approximately 1,000 stacked disc membranes that are densely packed with visual pigment rhodopsin. The mammalian OS is renewed every ten days; new discs are assembled at the base of the OS by a poorl...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.06.030
更新日期：2007-08-10 00:00:00
abstract：:Many proteins (intrinsically disordered proteins, IDPs) or regions of proteins (intrinsically disordered regions, IDRs) lack a well-defined 3D structure under physiological conditions. Albeit unfolded and highly dynamic, these proteins are not denatured; rather, intrinsic structural disorder is their native, functiona...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.05.024
更新日期：2015-05-21 00:00:00
abstract：:Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2007.09.030
更新日期：2007-10-05 00:00:00
abstract：:We have prepared polyclonal antibodies to the cytoplasmic portion of the envelope glycoprotein G of vesicular stomatitis virus (VSV) by using synthetic peptides corresponding to either the 22 or 11 ultimate carboxy-terminal residues of the G as immunogens. When antibodies to the 22 residue peptide are microinjected in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90195-8
更新日期：1984-11-01 00:00:00
abstract：:Null mutant mice for retinoic acid receptor gamma 2 (RAR gamma 2) or all RAR gamma isoforms were generated. RAR gamma 2 mutants appeared normal, whereas RAR gamma mutants exhibited growth deficiency, early lethality, and male sterility due to squamous metaplasia of the seminal vesicles and prostate. These defects were...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90246-m
更新日期：1993-05-21 00:00:00
abstract：:Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endot...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.08.027
更新日期：2011-09-16 00:00:00
abstract：:The yeast SIR2 gene is involved in regulating nucleosome phasing and transcription in the mating type system. We have found that SIR2 also plays another important role in the cell. Specifically, in wild-type SIR2 strains recombination between the tandemly repeated ribosomal RNA genes is depressed. In sir2 mutants, bot...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90681-8
更新日期：1989-03-10 00:00:00
abstract：:Extraction of glycerinated chicken skeletal muscle with 0.6 M potassium iodide leaves a framework of insoluble components within each muscle fiber. This framework is composed primarily of planes of in-register Z discs that have been thickened by the accumulation of material on both sides of each disc during extraction...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90051-x
更新日期：1978-12-01 00:00:00
abstract：:Scientists are stepping up like never before to support science in the public arena. In big and small ways, scientists are adopting creative ideas to promote science. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.03.029
更新日期：2017-04-06 00:00:00
abstract：:Eukaryotic cells have developed mechanisms for regulating the nuclear transport of macromolecules that control various cellular events including movement through defined stages of the cell cycle. In yeast cells, where the nuclear envelope remains intact throughout the cell cycle, these transport regulatory mechanisms ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00986-3
更新日期：2003-12-26 00:00:00
abstract：:The hemagglutinin of influenza virus is synthesized as a monomeric subunit that is cotranslationally translocated across the membrane of the rough endoplasmic reticulum. We show that folding and assembly of hemagglutinin monomers into trimeric structures takes approximately 7-10 min and is completed before the protein...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90076-0
更新日期：1986-09-12 00:00:00
abstract：:We wished to learn whether the genomes of strains of EMB isolated from patients with infectious mononucleosis are consistently distinguishable from those of strains from Burkitt's lymphoma. The genome of a new transforming strains (FF41) of EBV isolated from saliva of a patient with uncomplicated infectious mononucleo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90345-7
更新日期：1981-05-01 00:00:00
abstract：:The promise of human genetics and genomics is nothing less than a fully tailored life, starting with medical treatments, diets, and preventative care all styled around a single genome. There's a lighter side as well where consumer genomics companies are helping people understand themselves and their families. Lara Sze...
journal_title：Cell
pub_type： 面试
doi：10.1016/j.cell.2019.03.002
更新日期：2019-03-21 00:00:00
abstract：:In cells of the B-lymphocyte lineage, 8.4 kb transcripts are constitutively produced from unrearranged kappa constant region (kappa 0) loci. To help elucidate the molecular basis of this phenomenon, we have determined the nucleotide sequence surrounding the site of transcriptional initiation. The kappa 0 transcripts a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90401-3
更新日期：1981-12-01 00:00:00
abstract：:Centrosome duplication is a critical step in assembly of the bipolar mitotic spindle, but the molecular mechanisms regulating this process during the cell cycle and during animal development are poorly understood. Here, we report that the zyg-1 gene of Caenorhabditis elegans is an essential regulator of centrosome dup...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00338-5
更新日期：2001-05-18 00:00:00
abstract：:Viable yet damaged cells can accumulate during development and aging. Although eliminating those cells may benefit organ function, identification of this less fit cell population remains challenging. Previously, we identified a molecular mechanism, based on "fitness fingerprints" displayed on cell membranes, which all...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.12.017
更新日期：2015-01-29 00:00:00
abstract：:Polyglycylation is a posttranslational modification that generates glycine side chains on proteins. Here we identify a family of evolutionarily conserved glycine ligases that modify tubulin using different enzymatic mechanisms. In mammals, two distinct enzyme types catalyze the initiation and elongation steps of polyg...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.05.020
更新日期：2009-06-12 00:00:00
abstract：:The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.11.012
更新日期：2013-12-05 00:00:00
abstract：:LIM domains are zinc-binding protein sequences that are found in a growing number of proteins, including certain transcriptional regulators, proto-oncogene products, and adhesion plaque constituents. Here we define the biological activity of the LIM domain through studies of an adhesion plaque protein called zyxin tha...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90191-0
更新日期：1994-10-21 00:00:00
abstract：:We have examined the conformation of DNA cloned from the hypersensitive region 5' of the chicken adult beta-globin gene, in order to determine whether the unusual sensitivity to nucleases is related to altered secondary structure of the DNA. The region contains a large number of sites for methylation; we have studied ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90180-0
更新日期：1983-12-01 00:00:00
abstract：:Endophytic fungi are found within the roots of healthy plants, but their function is poorly understood. In this issue, Hiruma et al. demonstrate that, under phosphate-limiting conditions, the endophytic fungus, Colletotrichum tofieldiae, provides growth-promoting and fitness benefits to Arabidopsis, but the plant must...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.03.036
更新日期：2016-04-07 00:00:00
abstract：:Two studies from Jarosz et al. describe how [GAR(+)], a protein-based epigenetic determinant found mainly in wild yeast strains, can be activated by microbial cross-kingdom communication. With the aid of genetically and ecologically diverse bacteria, yeast can override an ancient regulatory mechanism of glucose repres...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2014.08.004
更新日期：2014-08-28 00:00:00
abstract：:The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis. Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal degradation, and p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.11.039
更新日期：2007-01-12 00:00:00
