Abstract:
:During HIV infection, the timing of opportunistic infections is not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens reactivate at different CD4 T cell thresholds. Here, we examine how differences in the phenotype and function of pathogen-specific CD4 T cells influence susceptibility to HIV infection. By focusing on three common opportunistic infections (Mycobacterium tuberculosis, human papillomavirus, and cytomegalovirus), we investigate how differential depletion of pathogen-specific CD4 T cells impacts the natural history of these pathogens in HIV infection. A broader understanding of this relationship can better inform treatment strategies against copathogens.
journal_name
Celljournal_title
Cellauthors
Saharia KK,Koup RAdoi
10.1016/j.cell.2013.09.045subject
Has Abstractpub_date
2013-10-24 00:00:00pages
505-14issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01219-1journal_volume
155pub_type
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